Detection of characteristic clusters in IMS-Spectrograms of exhaled air polluted with environmental contaminants

International Journal for Ion Mobility Spectrometry

Volumn 15, Issue 2, 2012, Pages 63-68

  Purkhart, Roman ^a   Hillmann, Anne ^a   Graupner, Rolf ^a   Becher, Gunther ^b  

^a Graupner GmbH and CoKG   (Germany)

^b BecherConsult GmbH   (Germany)

Author keywords

Cross validation; Disease marker; Environment; Exhaled breath; Support vector machine

Indexed keywords

AMBIENT AIR; CLASSIFICATION RATES; CROSS VALIDATION; DISEASE MARKERS; ENVIRONMENT; ENVIRONMENTAL BURDENS; ENVIRONMENTAL CONTAMINANT; ENVIRONMENTAL FACTORS; ENVIRONMENTAL POLLUTIONS; EXHALED BREATHS; ION MOBILITY SPECTROMETRY; MEDICAL DIAGNOSTICS; STATISTICAL EVALUATION; TEST ENVIRONMENT;

SPECTROMETRY; SPECTROSCOPY; SUPPORT VECTOR MACHINES;

DIAGNOSIS;

EID: 84860657710     PISSN: 14356163     EISSN: 18654584     Source Type: Journal    
DOI: 10.1007/s12127-012-0090-4     Document Type: Article

References (10)

1. Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J, Cataneo RN (1999) Variation in volatile organic compounds in the breath of normal humans. J Chromatogr Biomed Appl 729: 75-88.
2. Bödeker B, Davies AN, Maddula S, Baumbach JI (2010) Biomarker validation-room air variation during human breath investigations. Int J Ion Mobil Spec 13: 177-184.
3. Martin AN, Farquar GR, Jones AD, Frank M (2010) Human breath analysis: methods for sample collection and reduction of localized background effects. Anal Bioanal Chem 396: 739-750.
4. Piper JJ (1994) Search for Diffusion Limitation in Pulmonary Gas Exchange. The Pulmonary Circulation and Gas Exchange (Eds: Wagner): Futura Publishing Company Inc., Armonk, NY, ISBN 0-87993-572-3; pp 125-145.
5. Baumbach JI (2009) Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath. J Breath Res 3: 1-16.
6. Sionex Corporation (2010) microAnalyzer™ Series Product Manual S-400039 Revision A.
7. Pleil JD (2011) Meeting report: non invasive biomedical analysis. Breath networking session at PittCon 2011, Atlanta, Georgia. J. Breath Res. 5 029001.
8. Cortes C, Vapnik V (1995) Support-vector networks. Mach Learn 20: 273-297.
9. Ulanowska A, Ligor A, Amann A, Buszewski B (2008) Determination of volatile organic compounds in exhaled breath by ion mobility spectrometry. Chem Anal (Warsaw) 53: 953-965.
10. Anderson AG, Markoski, KA, Shi, Q, Coy, SL, Krylov, EV, Nazarov, EG (2008) DMS-IMS2, GC-DMS, DMS-MS: DMS Hybrid Devices Combining Orthogonal Principles of Separation for Challenging Applications. Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing IX, eds. Augustus Way Fountain III, Patrick J. Gardner, Proc. of SPIE Vol. 6954, 69540H.