Activated pericytes and the inhibition of renal vascular stability: Obstacles for kidney repair

Journal of the American Society of Nephrology

Volumn 23, Issue 5, 2012, Pages 767-769

  Basile, David P ^a   Sutton, Timothy A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS1 PROTEIN; GELATINASE; GELATINASE A; GELATINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 3; VASCULOTROPIN;

ANGIOGENESIS; CAPILLARY DENSITY; CELL ACTIVATION; CELL HYPOXIA; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; EDITORIAL; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROSIS; HUMAN; KIDNEY BLOOD VESSEL; KIDNEY SURGERY; LEYDIG CELL; MYOFIBROBLAST; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84860640533     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012030282     Document Type: Editorial

References (16)

1. Fine LG, Norman JT: Chronic hypoxia as amechanismof progression of chronic kidney diseases: From hypothesis to novel therapeutics. Kidney Int 74: 867-872, 2008
2. Zeisberg M, Neilson EG: Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 21: 1819-1834, 2010
3. Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK: Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 298: F1078-F1094, 2010
4. Lin S-L, Chang F-C, Schrimpf C, Chen Y-T, Wu C-F, Wu V-C, Chiang W-C, Kuhnert F, Kuo CJ, Chen Y-M, Wu K-D, Tsai T-J, Duffield JS: Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis. Am J Pathol 178: 911-923, 2011
5. Basile DP, Friedrich JL, Spahic J, Knipe NL, Mang HE, Leonard EC, Changizi-Ashtiyani S, Bacallao RL, Molitoris BA, Sutton TA: Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury. Am J Physiol Renal Physiol 300: F721-F733, 2011
6. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R: Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 19: 2282-2287, 2008
7. Schrimpf C, Xin C, Campanholle G, Gill SE, Stallcup W, Lin S-L, Davis GE, Gharib SA, Humphreys BD, Duffield JS: Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury. J Am SocNephrol 23: 868-883, 2012
8. Basile DP: The endothelial cell in ischemic acute kidney injury: Implications for acute and chronic function. Kidney Int 72: 151-156, 2007
9. Kamba T, Tam BYY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM: VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 290: H560-H576, 2006
10. Mundel TM, Kalluri R: Type IV collagen-derived angiogenesis inhibitors. Microvasc Res 74: 85-89, 2007 (Pubitemid 350051026)
11. Hörbelt M, Lee S-Y, Mang HE, Knipe NL, Sado Y, Kribben A, Sutton TA: Acute and chronicmicrovascular alterations in amousemodel of ischemic acute kidney injury. Am J Physiol Renal Physiol 293: F688-F695, 2007 (Pubitemid 47403338)
12. Tsukahara H, Gordienko DV, Tonshoff B, Gelato MC, Goligorsky MS: Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells. Kidney Int 45: 598-604, 1994 (Pubitemid 24065099)
13. Schmitt R, Cantley LG: The impact of aging on kidney repair. Am J Physiol Renal Physiol 294: F1265-F1272, 2008
14. Sutton TA, Kelly KJ, Mang HE, Plotkin Z, Sandoval RM, Dagher PC: Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury. Am J Physiol Renal Physiol 288: F91-F97, 2005 (Pubitemid 40038680)
15. Lee S-Y, Hörbelt M, Mang HE, Knipe NL, Bacallao RL, Sado Y, Sutton TA: MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury. Am J Physiol Renal Physiol 301: F101-F109, 2011
16. Handsley MM, Edwards DR: Metalloproteinases and their inhibitors in tumor angiogenesis. Int J Cancer 115: 849-860, 2005 (Pubitemid 40791824)