Evidence for a genetic overlap between body dysmorphic concerns and obsessive-compulsive symptoms in an adult female community twin sample

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 159 B, Issue 4, 2012, Pages 376-382

  Monzani, Benedetta ^a   Rijsdijk, Fruhling ^a   Iervolino, Alessandra C ^a   Anson, Martin ^b   Cherkas, Lynn ^c   Mataix Cols, David ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Body dysmorphic disorder; Classification; DSM 5; Heritability; Obsessive compulsive disorder; Twins

Indexed keywords

ADULT; AGED; ARTICLE; BODY DYSMORPHIC DISORDER; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; FEMALE; GENE; GENETIC TRAIT; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MONOZYGOTIC TWINS; OBSESSIVE COMPULSIVE DISORDER; PHENOTYPE; PRIORITY JOURNAL; RISK FACTOR; SOCIAL PHOBIA; SOMATOFORM DISORDER;

ADULT; BODY DYSMORPHIC DISORDERS; DEMOGRAPHY; FEMALE; HUMANS; MIDDLE AGED; MODELS, GENETIC; OBSESSIVE-COMPULSIVE DISORDER; RESIDENCE CHARACTERISTICS; TWINS;

EID: 84860633637     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32040     Document Type: Article

References (37)

1. Abramowitz J, Deacon B. 2006. Psychometric properties and construct validity of the Obsessive-Compulsive Inventory-Revised: Replication and extension with a clinical sample. J Anxiety Disord 20(8): 1016-1035.
2. Andrew T, Hart D, Snieder H, de Lange M, Spector TD, MacGregor AJ. 2001. Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res 4(6): 464-477.
3. American Psychiatric Association. 2000. Diagnostic and statistical manual of mental disorders, 4th edition. Text Revision. Washington, DC: American Psychiatric Association.
4. Bienvenu O, Samuels J, Riddle M, Howhn-Saric R, Liand K, Cullen B, et al. 2000. The relationship of obsessive-compulsive disorder to possible spectrum disorders: Results from a family study. Biol Psychiatry 48: 287-293.
5. Bienvenu OJ, Samuels JF, Wuyek LA, Liang KY, Wang Y, Grados MA, Cullen BA, Riddle MA, Greenberg BD, Rasmussen SA, Fyer AJ, Pinto A, Rauch SL, Pauls DL, McCracken JT, Piacentini J, Murphy DL, Knowles JA, Nestadt G. 2012. Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. Psychol Med 42(1): 1-13.
6. Buhlmann U, Cook LM, Fama JM, Wilhelm S. 2007. Perceived teasing experiences in body dysmorphic disorder. Body Image 4(4): 381-385.
7. Chosak A, Marques L, Greenberg J, Jenike E, Dougherty D, Wilhelm S. 2008. Body dysmorphic disorder and obsessive-compulsive disorder: Similarities, differences and the classification debate. Expert Rev Neurother 8(8): 1209-1218.
8. Clifford C, Murray R, Fulker D. 1984. Genetic and environmental influences on obsessional traits and symptoms. Psychol Med 14(4): 791-800.
9. Derks EM, Dolan CV, Boomsma DI. 2004. Effects of censoring on parameter estimates and power in genetic modeling. Twin Res 7(6): 659-669.
10. Didie E, Walters M, Pinto A, Menard W, Eisen J, Mancebo M, Rasmussen S, Phillips K. 2007. A comparison of quality of life and psychosocial functioning in obsessive-compulsive disorder and body dysmorphic disorder. Ann Clin Psychiatry 19(4): 331.
11. Feusner J, Moody T, Hembacher E, Townsend J, McKinley M, Moller H, Bookheimer S. 2010. Abnormalities of visual processing and frontostriatal systems in body dysmorphic disorder. Arch Gen Psychiatry 67(2): 197-205.
12. Foa EB, Huppert JD, Leiberg S, Langner R, Kichic R, Hajcak G, Salkovskis PM. 2002. The Obsessive-Compulsive Inventory: Development and validation of a short version. Psychol Assess 14(4): 485-496.
13. Frare F, Perugi G, Ruffolo G, Toni C. 2004. Obsessive-compulsive disorder and body dysmorphic disorder a comparison of clinical features Eur Psychiatry 19(5): 292-298.
14. Gönner S, Hahn S, Leonhart R, Ecker W, Limbacher K. 2009. Identifikation der Hauptsymptome von Zwangspatienten anhand von Symptomskalen-Kriteriumsvalidität und diagnostische Genauigkeit des OCI-R. [Identification of main symptoms in OCD patients by use of symptom scales-Criterion validity and diagnostic accuracy of the OCI-R]. Verhaltenstherapie 19: 251-258.
15. Grisham J, Fullana M, Mataix-Cols D, Moffitt T, Caspi A, Poulton R. 2011. Risk factors prospectively associated with adult obsessive-compulsive symptom dimensions and obsessive-compulsive disorder. Psychol Med 41: 2495-2506.
16. Gunstad J, Phillips K. 2003. Axis I comorbidity in body dysmorphic disorder. Compr Psychiatry 44(4): 270-276.
17. Hettema J, Neale M, Kendler K. 2001. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158(10): 1568-1578.
18. Iervolino A, Rijsdijk F, Cherkas L, Fullana M, Mataix-Cols D. 2011. A multivariate twin study of obsessive-compulsive symptom dimensions. Arch Gen Psychiatry 68(6): 637-644.
19. Jonnal A, Gardner C, Prescott C, Kendler K. 2000. Obsessive and compulsive symptoms in a general population sample of female twins. Am J Med Genet 96(6): 791-796.
20. Jorgensen L, Castle D, Roberts C, Groth-Marnat G. 2001. A clinical validation of the Dysmorphic Concern Questionnaire. Aust N Z J Psychiatry 35(1): 124-128.
21. Joseph J. 2002. Twin studies in psychiatry psychology science or pseudoscience? Psychiatr Q 73(1): 71-82.
22. Lambrou C. 2006. The role of aesthetic sensitivity in body dysmorphic disorder. London: Institute of Psychiatry, University of London.
23. Mancuso SG, Knoesen NP, Castle DJ. 2010. The Dysmorphic Concern Questionnaire: A screening measure for body dysmorphic disorder. Aust N Z J Psychiatry 44(6): 535-542.
24. Monzani B, Rijsdijk F, Anson M, Iervolino AC, Cherkas L, Spector T, Mataix-Cols D. 2012. A twin study of body dysmorphic concerns. Psychol Med In press. DOI: 10.1017/S0033291711002741
25. Neale M, Cardon L. 1992. Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer Academic.
26. Neziroglu F, Khemlani-Patel S, Yaryura-Tobias JA. 2006. Rates of abuse in body dysmorphic disorder and obsessive-compulsive disorder. Body Image 3(2): 189-193.
27. Oosthuizen P, Lambert T, Castle D. 1998. Dysmorphic concern: Prevalence and associations with clinical variables. Austr N Z J Psychiatry 32: 129-132.
28. Phillips K. 2001. Body dysmorphic disorder. In: Phillips K, editor. Somatoform and factitious disorders. Washington, DC: American Psychiatric Publishing. pp 67-94.
29. Phillips K, Menard W, Fay C, Weisberg R. 2005. Demographic characteristics, phenomenology, comorbidity, and family history in 200 individuals with body dysmorphic disorder. Psychosomatics 46(4): 317-325.
30. Phillips K, Wilhelm S, Koran LM, Didie E, Fallon B, Feusner J, Stein D. 2010. Body dysmorphic disorder: Some key issues for DSM-V. Depress Anxiety 27(6): 573-591.
31. Sarna S, Kaprio J, Sistonen P, Koskenvuo M. 1978. Diagnosis of twin zygosity by mailed questionnaires. Hum Hered 28: 241-254.
32. Spector T, William F. 2006. The UK Adult Twin Registry (TwinsUK). Twin Res Hum Genet 9: 899-906.
33. Stangier U, Janich C, Adam-Schwebe S, Berger P, Wolter M. 2003. Screening for body dysmorphic disorder in dermatological outpatients. Dermatol Psychosom 4: 66-71.
34. Tsuang K, Kendler S, Lyons MJ, editors. 1991. Genetic issues in psychosocial epidemiology. New Brunswick, NJ: Rutgers University Press. pp 191-212.
35. Van Grootheest D, Cath D, Beekman A, Boomsma D. 2005. Twin studies on obsessive-compulsive disorder: A review. Twin Res Hum Genet 8(5): 450-458.
36. Van Grootheest D, Cath D, Beekman A, Boomsma D. 2007. Genetic and environmental influences on obsessive-compulsive symptoms in adults: A population-based win-family study. Psychol Med 37(11): 1635-1644.
37. Veale D, Neziroglu F. 2010. Body dysmorphic disorder: A treatment manual. Oxford, UK: Wiley-Blackwell.