Acute Effects of Nicardipine and Esmolol on The Cardiac Cycle, Intracardiac Hemodynamic and Endothelial Shear Stress in Patients With Unstable Angina Pectoris and Moderate Coronary Stenosis: Results From Single Center, Randomized Study

Cardiovascular Therapeutics

Volumn 30, Issue 3, 2012, Pages 162-171

  Chen, Shao Liang ^a   Hu, Zuo Ying ^a   Zhang, Jun Jie ^a   Ye, Fei ^a   Kan, Jing ^a   Xu, Tian ^a   Liu, Zhi Zhong ^a   Zhang, Yao Jun ^a   Zhang, Jun Xia ^a   Chen, Mengxuan ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b St Margaret School   (Canada)

Author keywords

Cardiac cycle; Endothelial shear; Esmolol; Hemodynamic; Nicardipine; Stress

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; CLOPIDOGREL; ESMOLOL; METOPROLOL; NICARDIPINE;

AGED; ANGIOCARDIOGRAPHY; AORTA PRESSURE; ARTICLE; BLOOD FLOW VELOCITY; CONTINUOUS INFUSION; CORONARY ARTERY OBSTRUCTION; CORONARY ARTERY PRESSURE; DRUG EFFECT; ENDOTHELIAL SHEAR STRESS; FEMALE; HEART CYCLE; HEART HEMODYNAMICS; HEART PROTECTION; HEART RATE; HEART RIGHT ATRIUM PRESSURE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; SHEAR STRESS; SIDE EFFECT; STEADY STATE; SYSTOLIC TIME INTERVAL; UNSTABLE ANGINA PECTORIS;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; AGED; ANALYSIS OF VARIANCE; ANGINA, UNSTABLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CHI-SQUARE DISTRIBUTION; CHINA; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CORONARY STENOSIS; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; HEART CATHETERIZATION; HEART RATE; HEMODYNAMICS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; NICARDIPINE; PROPANOLAMINES; SEVERITY OF ILLNESS INDEX; STRESS, MECHANICAL; TIME FACTORS; TREATMENT OUTCOME;

EID: 84860633218     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2011.00298.x     Document Type: Article

References (27)

1. Egan BM, Basile J, Chilton RJ, Cohen JD. Cardioprotection: The role of β-Blocker therapy. JCH 2007;7:409-416.
2. Cook NS, Hof RP. Cardioprotection by the calcium antagonist PN 200-110 in the absence and presence of cardiodepression. Br J Pharmacol 1985;86:181-189.
3. Clement DL, De Buyzere D, Duprez D. Antihypertensive effects of calcium antagonists. Clinical facts and modulating factors. Am J Hypertens 1994;7:16S-22S.
4. Cucherat M. Quantative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: A meta-regression of randomized clinical trials. Eur Heart J 2007;28:3012-3019.
5. Cheng C, Tempel D, van Haperen R, et al. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation 2006;113:2744-2753.
6. Slager CJ, Wentzel JJ, Gijsen FJ, et al. The role of shear stress in the generation of rupture-prone vulnerable plaques. Nat Clin Pract Cardiovasc Med 2005; 2:401-407.
7. VanderLaan PA, Reardon CA, Getz GS. Site specificity of atherosclerosis: Site-selective responses to atherosclerotic modulators. Arterioscler Thromb Vasc Biol 2004;24:12-22.
8. Weinbaum S, Tzeghai G, Ganatos P, Pfeffer R, Chien S. Effect of cell turnover and leaky junctions on arterial macromolecular transport. Am J Physiol Heart Circ Physiol 1985;248:H945-H960.
9. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987;316:1371-1375.
10. Krams R, Wentzel J, Oomen J, et al. Evaluation of endothelial shear stress and 3D geometry as factors determining the development of atherosclerosis and remodeling in human coronary arteries in vivo. Combining 3D reconstruction from angiography and IVUS (ANGUS) with computational fluid dynamics. Arterioscler Thromb Vasc Biol 1997;17:2061-2065.
11. Askenazi J, MacCosbe PE, Hoff J, Turlapaty P, Hua TA, Laddu A. Hemodynamic effects of esmolol, an ultrashort-acting beta blocker. J Clin Pharmacol 1987;27:567-573.
12. Gijsen FJH, Wentze JJ, Thury A, et al. Strain distribution over plaques in human coronary arteries relates to shear stress. Am J Physiol Heart Circ Physiol 2008;295:H1608-H1614.
13. Hu ZY, Chen SL, Zhang JJ, et al. Distribution and magnitude of shear stress after coronary bifurcation lesions stenting with the classical crush technique: a new predictor for in-stent restenosis. J Interv Cardiol 2010;23:330-340.
14. Ninomiya Y, Hamasaki S, Saihara K, et al. Comparison of effect between nitrates and calcium channel antagonist on vascular function in patients with normal or mildly diseased coronary arteies. Heart Vessels 2008;23:83-90.
15. Franklin SS, Gustin WT, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Hemodynamic patterns of aged-related changes in blood pressure. Circulation 1997;96:308-315.
16. Fox K, Ford I, Steg PG, et al. Heart rate as prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): A subgroup analysis of a randomized controlled trial. Lancet 2008;372:817-821.
17. Ahmadi-Kashani MKD, Day J, Bunch TJ, et al., on behalf of the INTRINSIC RV Study Investigators. Heart rate predicts outcomes in an implantable cardioverter-defibrillator population. Circulation 2009;120:2040-2045.
18. Berk BC. Atheroprotective signaling mechanisms activated by stady laminar flow in endothelial cells. Circulation 2008;117:1082-1089.
19. Perski A, Olsson G, Landou C, de Faire U, Theorell T, Hamsten A. Minimum heart rate and coronary atherosclerosis: Independent raltions to global severity and rate of progression of angiographic lesions in men with myocardial infarction at a young age. Am Heart J 1992;123:609-616.
20. Heidland UE, Strauer BE. Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption. Circulation 2001;104:1477-1482.
21. Bangalore S, Sawhney S, Messerli FH. Relation of beta-blocker-induced heart rate lowering and cardioprotection in hypertension. J Am Coll Cardiol 2008;52:1482-1489.
22. Williams B, Lacy PS. Impact of heart rate on central aortic pressure and hemodynamics: Analysis from the CAFÉ (Conduit Artery Function Evaluation) study: CAFÉ-Heat Rate. J Am Coll Cardiol 2009;54:705-713.
23. Wentzel JJ, Janssen E, Vos J, et al. Extension of increased atherosclerotic wall thickness into high shear stress regions is associated with loss of compensatory remodeling. Circulation 2003;108:17-23.
24. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA 1999;282:2035-2042.
25. Fukumoto Y, Hiro T, Fuji T, et al. Localized Elevation of Shear Stress Is Related to Coronary Plaque Rupture.A 3-Dimensional Intravascular Ultrasound Study With In-Vivo Color Mapping of Shear Stress Distribution. JACC 2008;51:645-650.
26. Peter HS, Ahmet UC, Scott K, et al. Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study. Eur Heart J 2007;28:705-710.
27. Stone PH, Coskun AU, Kinlay S, et al. Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study. Circulation 2003;108:438-444.