메뉴 건너뛰기




Volumn 5, Issue , 2012, Pages

Recent advances and novel agents for gastrointestinal stromal tumor (GIST)

Author keywords

[No Author keywords available]

Indexed keywords

CRENOLANIB; DASATINIB; EVEROLIMUS; GANETESPIB; IMATINIB; MASITINIB; MOTESANIB; NILOTINIB; PERIFOSINE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; RAPAMYCIN; REGORAFENIB; RETASPIMYCIN; SORAFENIB; STEM CELL FACTOR RECEPTOR; SUNITINIB; VATALANIB;

EID: 84860631629     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-5-21     Document Type: Review
Times cited : (27)

References (65)
  • 1
    • 0034015511 scopus 로고    scopus 로고
    • Molecular insights into the histogenesis and pathogenesis of gastrointestinal stromal tumors
    • Molecular Insights into the Histogenesis and Pathogenesis of Gastrointestinal Stromal Tumors. Rubin BP, Fletcher JA, Fletcher CD, Int J Surg Pathol 2000 8 1 5 10 10.1177/106689690000800105 11493959 (Pubitemid 30129563)
    • (2000) International Journal of Surgical Pathology , vol.8 , Issue.1 , pp. 5-10
    • Rubin, B.P.1    Fletcher, J.A.2    Fletcher, C.D.M.3
  • 3
    • 0036301863 scopus 로고    scopus 로고
    • Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: A review
    • DOI 10.1053/hupa.2002.124123
    • Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Miettinen M, El-Rifai W, L HLS, Lasota J, Hum Pathol 2002 33 5 478 483 10.1053/hupa.2002.124123 12094372 (Pubitemid 34747866)
    • (2002) Human Pathology , vol.33 , Issue.5 , pp. 478-483
    • Miettinen, M.1    El-Rifai, W.2    Sobin, L.3    Lasota, J.4
  • 6
    • 0041971080 scopus 로고    scopus 로고
    • Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors
    • DOI 10.1016/S0016-5085(03)01046-1
    • Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, Kitamura Y, Gastroenterology 2003 125 3 660 667 10.1016/S0016-5085(03)01046-1 12949711 (Pubitemid 37070684)
    • (2003) Gastroenterology , vol.125 , Issue.3 , pp. 660-667
    • Hirota, S.1    Ohashi, A.2    Nishida, T.3    Isozaki, K.4    Kinoshita, K.5    Shinomura, Y.6    Kitamura, Y.7
  • 8
    • 67650480850 scopus 로고    scopus 로고
    • V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours
    • 10.1136/jcp.2009.064550 19561230
    • V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours. Agaimy A, Terracciano LM, Dirnhofer S, Tornillo L, Foerster A, Hartmann A, Bihl MP, J Clin Pathol 2009 62 7 613 616 10.1136/jcp.2009.064550 19561230
    • (2009) J Clin Pathol , vol.62 , Issue.7 , pp. 613-616
    • Agaimy, A.1    Terracciano, L.M.2    Dirnhofer, S.3    Tornillo, L.4    Foerster, A.5    Hartmann, A.6    Bihl, M.P.7
  • 11
    • 84864402031 scopus 로고    scopus 로고
    • NCCN National comprehensive cancer network guidelines
    • National Comprehensive Cancer Network Guidelines. NCCN, National Comprehensive Cancer Network Guidelines 2012 2012 2 2012
    • (2012) National Comprehensive Cancer Network Guidelines , vol.2012 , Issue.2 , pp. 2012
  • 16
    • 24944529613 scopus 로고    scopus 로고
    • Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study
    • 10.1200/JCO.2005.11.601 16110036
    • Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study. Van Glabbeke M, Verweij J, Casali PG, Le Cesne A, Hohenberger P, Ray-Coquard I, Schlemmer M, van Oosterom AT, Goldstein D, Sciot R, et al. J Clin Oncol 2005 23 24 5795 5804 10.1200/JCO.2005.11.601 16110036
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5795-5804
    • Van Glabbeke, M.1    Verweij, J.2    Casali, P.G.3    Le Cesne, A.4    Hohenberger, P.5    Ray-Coquard, I.6    Schlemmer, M.7    Van Oosterom, A.T.8    Goldstein, D.9    Sciot, R.10
  • 18
    • 67651012675 scopus 로고    scopus 로고
    • Does imatinib turn recurrent and/or metastasized gastrointestinal stromal tumors into a chronic disease? - Single center experience
    • 10.1097/MEG.0b013e32830b0f76 19369884
    • Does imatinib turn recurrent and/or metastasized gastrointestinal stromal tumors into a chronic disease?-single center experience. Armbrust T, Sobotta M, Gunawan B, Fuzesi L, Langer C, Cameron S, Ramadori G, Eur J Gastroenterol Hepatol 2009 21 7 819 823 10.1097/MEG.0b013e32830b0f76 19369884
    • (2009) Eur J Gastroenterol Hepatol , vol.21 , Issue.7 , pp. 819-823
    • Armbrust, T.1    Sobotta, M.2    Gunawan, B.3    Fuzesi, L.4    Langer, C.5    Cameron, S.6    Ramadori, G.7
  • 22
    • 56749156604 scopus 로고    scopus 로고
    • Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group
    • 10.1200/JCO.2008.17.4284 18955451
    • Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group. Heinrich MC, Owzar K, Corless CL, Hollis D, Borden EC, Fletcher CD, Ryan CW, von Mehren M, Blanke CD, Rankin C, et al. J Clin Oncol 2008 26 33 5360 5367 10.1200/JCO.2008.17.4284 18955451
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5360-5367
    • Heinrich, M.C.1    Owzar, K.2    Corless, C.L.3    Hollis, D.4    Borden, E.C.5    Fletcher, C.D.6    Ryan, C.W.7    Von Mehren, M.8    Blanke, C.D.9    Rankin, C.10
  • 24
    • 77949898532 scopus 로고    scopus 로고
    • Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: A meta-analysis of 1,640 patients
    • Gastrointestinal Stromal Tumor Meta-Analysis G 20124181
    • Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: a meta-analysis of 1,640 patients. Gastrointestinal Stromal Tumor Meta-Analysis G, J Clin Oncol 2010 28 7 1247 1253 20124181
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1247-1253
  • 27
    • 77957341199 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with advanced gastrointestinal stromal tumours after 3 years of treatment: An open-label multicentre randomised phase 3 trial
    • 10.1016/S1470-2045(10)70222-9 20864406
    • Discontinuation of imatinib in patients with advanced gastrointestinal stromal tumours after 3 years of treatment: an open-label multicentre randomised phase 3 trial. Le Cesne A, Ray-Coquard I, Bui BN, Adenis A, Rios M, Bertucci F, Duffaud F, Chevreau C, Cupissol D, Cioffi A, et al. Lancet Oncol 2010 11 10 942 949 10.1016/S1470-2045(10)70222-9 20864406
    • (2010) Lancet Oncol , vol.11 , Issue.10 , pp. 942-949
    • Le Cesne, A.1    Ray-Coquard, I.2    Bui, B.N.3    Adenis, A.4    Rios, M.5    Bertucci, F.6    Duffaud, F.7    Chevreau, C.8    Cupissol, D.9    Cioffi, A.10
  • 28
    • 84857641974 scopus 로고    scopus 로고
    • Time to secondary resistance (TSR) after interruption of imatinib (IM) in advanced GIST: Updated results of the prospective French Sarcoma Group randomized phase III trial on long-term survival
    • Time to secondary resistance (TSR) after interruption of imatinib (IM) in advanced GIST: updated results of the prospective French Sarcoma Group randomized phase III trial on long-term survival. Le Cesne A, Ray-Coquard IL, Bui-Nguyen B, Adenis A, Rios M, Bertucci F, Duffaud F, Cupissol D, Chevreau C, Bompas E, et al. ASCO Meeting Abstracts 2011 29 15 -uppl 10015
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.15 , pp. 10015
    • Le Cesne, A.1    Ray-Coquard, I.L.2    Bui-Nguyen, B.3    Adenis, A.4    Rios, M.5    Bertucci, F.6    Duffaud, F.7    Cupissol, D.8    Chevreau, C.9    Bompas, E.10
  • 29
    • 84864302470 scopus 로고    scopus 로고
    • Influence of imatinib interruption and imatinib rechallenge on the residual tumor volume in patients with advanced GIST: Results of the BFR14 prospective French Sarcoma Group randomized phase III trial
    • Influence of imatinib interruption and imatinib rechallenge on the residual tumor volume in patients with advanced GIST: results of the BFR14 prospective French Sarcoma Group randomized phase III trial. Domont J, Blay J, Ray-Coquard IL, Bui-Nguyen B, Adenis A, Rios M, Bertucci F, Duffaud F, Cupissol D, Chevreau C, et al. ASCO Meeting Abstracts 2011 29 15-suppl 10054
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.15 SUPPL. , pp. 10054
    • Domont, J.1    Blay, J.2    Ray-Coquard, I.L.3    Bui-Nguyen, B.4    Adenis, A.5    Rios, M.6    Bertucci, F.7    Duffaud, F.8    Cupissol, D.9    Chevreau, C.10
  • 33
    • 33744795769 scopus 로고    scopus 로고
    • Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors
    • DOI 10.1200/JCO.2005.05.3439
    • Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors. Raut CP, Posner M, Desai J, Morgan JA, George S, Zahrieh D, Fletcher CD, Demetri GD, Bertagnolli MM, J Clin Oncol 2006 24 15 2325 2331 10.1200/JCO.2005.05.3439 16710031 (Pubitemid 46630664)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.15 , pp. 2325-2331
    • Raut, C.P.1    Posner, M.2    Desai, J.3    Morgan, J.A.4    George, S.5    Zahrieh, D.6    Fletcher, C.D.M.7    Demetri, G.D.8    Bertagnolli, M.M.9
  • 34
    • 18844457915 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: New nodule-within-A-mass pattern of recurrence after partial response to imatinib mesylate
    • DOI 10.1148/radiol.2353040332
    • Gastrointestinal stromal tumor: new nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate. Shankar S, vanSonnenberg E, Desai J, Dipiro PJ, Van Den Abbeele A, Demetri GD, Radiology 2005 235 3 892 898 10.1148/radiol.2353040332 15833985 (Pubitemid 40695886)
    • (2005) Radiology , vol.235 , Issue.3 , pp. 892-898
    • Shankar, S.1    VanSonnenberg, E.2    Desai, J.3    DiPiro, P.J.4    Van Den Abbeele, A.5    Demetri, G.D.6
  • 35
    • 23644452642 scopus 로고    scopus 로고
    • Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg
    • DOI 10.1016/j.ejca.2005.04.034, PII S0959804905004405
    • Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Zalcberg JR, Verweij J, Casali PG, Le Cesne A, Reichardt P, Blay JY, Schlemmer M, Van Glabbeke M, Brown M, Judson IR, et al. Eur J Cancer 2005 41 12 1751 1757 10.1016/j.ejca.2005.04.034 16098458 (Pubitemid 41132637)
    • (2005) European Journal of Cancer , vol.41 , Issue.12 , pp. 1751-1757
    • Zalcberg, J.R.1    Verweij, J.2    Casali, P.G.3    Le Cesne, A.4    Reichardt, P.5    Blay, J.-Y.6    Schlemmer, M.7    Van Glabbeke, M.8    Brown, M.9    Judson, I.R.10
  • 37
    • 70349471245 scopus 로고    scopus 로고
    • Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure
    • 10.1158/1078-0432.CCR-09-0482 19737946
    • Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure. Demetri GD, Heinrich MC, Fletcher JA, Fletcher CD, Van den Abbeele AD, Corless CL, Antonescu CR, George S, Morgan JA, Chen MH, et al. Clin Cancer Res 2009 15 18 5902 5909 10.1158/1078-0432.CCR-09-0482 19737946
    • (2009) Clin Cancer Res , vol.15 , Issue.18 , pp. 5902-5909
    • Demetri, G.D.1    Heinrich, M.C.2    Fletcher, J.A.3    Fletcher, C.D.4    Van Den Abbeele, A.D.5    Corless, C.L.6    Antonescu, C.R.7    George, S.8    Morgan, J.A.9    Chen, M.H.10
  • 39
    • 84857519572 scopus 로고    scopus 로고
    • Sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): Final results of a University of Chicago Phase II Consortium trial
    • Sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): Final results of a University of Chicago Phase II Consortium trial. Kindler HL, Campbell NP, Wroblewski K, Maki RG, DAdamo DR, Chow WA, Gandara DR, Antonescu C, Stadler WM, Vokes EE, ASCO Meeting Abstracts 2011 29 15-suppl 10009
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.15 SUPPL. , pp. 10009
    • Kindler, H.L.1    Campbell, N.P.2    Wroblewski, K.3    Maki, R.G.4    Dadamo, D.R.5    Chow, W.A.6    Gandara, D.R.7    Antonescu, C.8    Stadler, W.M.9    Vokes, E.E.10
  • 40
    • 84864293774 scopus 로고    scopus 로고
    • Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib
    • Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib. Reichardt P, Blay JY, Gelderblom H, Schlemmer M, Demetri GD, Bui-Nguyen B, McArthur GA, Yazji S, Hsu Y, Galetic I, et al. Ann Oncol 2012 23
    • (2012) Ann Oncol , vol.23
    • Reichardt, P.1    Blay, J.Y.2    Gelderblom, H.3    Schlemmer, M.4    Demetri, G.D.5    Bui-Nguyen, B.6    McArthur, G.A.7    Yazji, S.8    Hsu, Y.9    Galetic, I.10
  • 41
    • 84864408861 scopus 로고    scopus 로고
    • Sorafenib in patients with metastatic gastrointestinal stromal tumors who failed two or more prior tyrosine kinase inhibitors: A phase II study of Korean gastrointestinal stromal tumors study group
    • 21499733
    • Sorafenib in patients with metastatic gastrointestinal stromal tumors who failed two or more prior tyrosine kinase inhibitors: a phase II study of Korean gastrointestinal stromal tumors study group. Park SH, Ryu MH, Ryoo BY, Im SA, Kwon HC, Lee SS, Park SR, Kang BY, Kang YK, Invest New Drugs 2012 30 21499733
    • (2012) Invest New Drugs , vol.30
    • Park, S.H.1    Ryu, M.H.2    Ryoo, B.Y.3    Im, S.A.4    Kwon, H.C.5    Lee, S.S.6    Park, S.R.7    Kang, B.Y.8    Kang, Y.K.9
  • 43
    • 72549086618 scopus 로고    scopus 로고
    • Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: An in vitro mutagenesis screen for drug resistance
    • 10.1158/1078-0432.CCR-09-1315 19861442
    • Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: an in vitro mutagenesis screen for drug resistance. Guo T, Hajdu M, Agaram NP, Shinoda H, Veach D, Clarkson BD, Maki RG, Singer S, Dematteo RP, Besmer P, et al. Clin Cancer Res 2009 15 22 6862 6870 10.1158/1078-0432.CCR-09-1315 19861442
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 6862-6870
    • Guo, T.1    Hajdu, M.2    Agaram, N.P.3    Shinoda, H.4    Veach, D.5    Clarkson, B.D.6    Maki, R.G.7    Singer, S.8    Dematteo, R.P.9    Besmer, P.10
  • 46
    • 53249152139 scopus 로고    scopus 로고
    • Activity of dasatinib, a dual SRC/ABL kinase inhibitor, and IPI-504, a heat shock protein 90 inhibitor, against gastrointestinal stromal tumor-associated PDGFRAD842V mutation
    • 10.1158/1078-0432.CCR-08-0533 18794084
    • Activity of dasatinib, a dual SRC/ABL kinase inhibitor, and IPI-504, a heat shock protein 90 inhibitor, against gastrointestinal stromal tumor-associated PDGFRAD842V mutation. Dewaele B, Wasag B, Cools J, Sciot R, Prenen H, Vandenberghe P, Wozniak A, Schoffski P, Marynen P, Debiec-Rychter M, Clin Cancer Res 2008 14 18 5749 5758 10.1158/1078-0432.CCR-08-0533 18794084
    • (2008) Clin Cancer Res , vol.14 , Issue.18 , pp. 5749-5758
    • Dewaele, B.1    Wasag, B.2    Cools, J.3    Sciot, R.4    Prenen, H.5    Vandenberghe, P.6    Wozniak, A.7    Schoffski, P.8    Marynen, P.9    Debiec-Rychter, M.10
  • 47
    • 70349459886 scopus 로고    scopus 로고
    • A phase i study of single-agent nilotinib or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors
    • 10.1158/1078-0432.CCR-09-0542 19723647
    • A phase I study of single-agent nilotinib or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors. Demetri GD, Casali PG, Blay JY, von Mehren M, Morgan JA, Bertulli R, Ray-Coquard I, Cassier P, Davey M, Borghaei H, et al. Clin Cancer Res 2009 15 18 5910 5916 10.1158/1078-0432.CCR-09-0542 19723647
    • (2009) Clin Cancer Res , vol.15 , Issue.18 , pp. 5910-5916
    • Demetri, G.D.1    Casali, P.G.2    Blay, J.Y.3    Von Mehren, M.4    Morgan, J.A.5    Bertulli, R.6    Ray-Coquard, I.7    Cassier, P.8    Davey, M.9    Borghaei, H.10
  • 48
    • 79959596313 scopus 로고    scopus 로고
    • Efficacy and safety of motesanib, an oral inhibitor of VEGF, PDGF, and Kit receptors, in patients with imatinib-resistant gastrointestinal stromal tumors
    • 10.1007/s00280-010-1431-9 20838998
    • Efficacy and safety of motesanib, an oral inhibitor of VEGF, PDGF, and Kit receptors, in patients with imatinib-resistant gastrointestinal stromal tumors. Benjamin RS, Schoffski P, Hartmann JT, Van Oosterom A, Bui BN, Duyster J, Schuetze S, Blay JY, Reichardt P, Rosen LS, et al. Cancer Chemother Pharmacol 2011 68 1 69 77 10.1007/s00280-010-1431-9 20838998
    • (2011) Cancer Chemother Pharmacol , vol.68 , Issue.1 , pp. 69-77
    • Benjamin, R.S.1    Schoffski, P.2    Hartmann, J.T.3    Van Oosterom, A.4    Bui, B.N.5    Duyster, J.6    Schuetze, S.7    Blay, J.Y.8    Reichardt, P.9    Rosen, L.S.10
  • 49
    • 59949103514 scopus 로고    scopus 로고
    • Activity of sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): A phase II trial of the University of Chicago Phase II Consortium
    • Activity of sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): A phase II trial of the University of Chicago Phase II Consortium. Wiebe L, Kasza KE, Maki RG, DAdamo DR, Chow WA, Wade JL, Agamah E, Stadler WM, Vokes EE, Kindler HL, ASCO Meeting Abstracts 2008 26 15-suppl 10502
    • (2008) ASCO Meeting Abstracts , vol.26 , Issue.15 SUPPL. , pp. 10502
    • Wiebe, L.1    Kasza, K.E.2    Maki, R.G.3    Dadamo, D.R.4    Chow, W.A.5    Wade, J.L.6    Agamah, E.7    Stadler, W.M.8    Vokes, E.E.9    Kindler, H.L.10
  • 50
    • 79958823445 scopus 로고    scopus 로고
    • Final results of a University of Chicago phase II consortium trial of sorafenib (SOR) in patients (pts) with imatinib (IM)- and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST)
    • Final results of a University of Chicago phase II consortium trial of sorafenib (SOR) in patients (pts) with imatinib (IM)- and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST). Campbell NP, Wroblewski K, Maki RG, DAdamo DR, Chow WA, Gandara DR, Antonescu C, Stadler WM, Vokes EE, Kindler HL, ASCO Meeting Abstracts 2011 29 4-suppl 4
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.4 , pp. 4
    • Campbell, N.P.1    Wroblewski, K.2    Maki, R.G.3    Dadamo, D.R.4    Chow, W.A.5    Gandara, D.R.6    Antonescu, C.7    Stadler, W.M.8    Vokes, E.E.9    Kindler, H.L.10
  • 52
    • 80054062297 scopus 로고    scopus 로고
    • A multicenter phase II study of regorafenib in patients (pts) with advanced gastrointestinal stromal tumor (GIST), after therapy with imatinib (IM) and sunitinib (SU)
    • A multicenter phase II study of regorafenib in patients (pts) with advanced gastrointestinal stromal tumor (GIST), after therapy with imatinib (IM) and sunitinib (SU). George S, von Mehren M, Heinrich MC, Wang Q, Corless CL, Butrynski JE, Morgan JA, Wagner AJ, Choy E, Tap WD, et al. ASCO Meeting Abstracts 2011 29 15-suppl 10007
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.15 SUPPL. , pp. 10007
    • George, S.1    Von Mehren, M.2    Heinrich, M.C.3    Wang, Q.4    Corless, C.L.5    Butrynski, J.E.6    Morgan, J.A.7    Wagner, A.J.8    Choy, E.9    Tap, W.D.10
  • 53
    • 84864409444 scopus 로고    scopus 로고
    • Overall survival benefit with masitinib mesylate in imatinib-naive, locally advanced, or metastatic gastrointestinal stromal tumor (GIST): 4-years follow-up of the French Sarcoma Group phase II trial
    • Overall survival benefit with masitinib mesylate in imatinib-naive, locally advanced, or metastatic gastrointestinal stromal tumor (GIST): 4-years follow-up of the French Sarcoma Group phase II trial. Blay J, Le Cesne A, Bin-Bui N, Bouche O, Adenis A, Julien D, Cioffi A, Moussy A, Hermine O, ASCO Meeting Abstracts 2011 29 4-suppl 85
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.4 SUPPL. , pp. 85
    • Blay, J.1    Le Cesne, A.2    Bin-Bui, N.3    Bouche, O.4    Adenis, A.5    Julien, D.6    Cioffi, A.7    Moussy, A.8    Hermine, O.9
  • 54
    • 84857557900 scopus 로고    scopus 로고
    • The effect of crenolanib (CP-868596) on phosphorylation of the imatinib-resistant D842V PDGFRA activating mutation associated with advanced gastrointestinal stromal tumors
    • The effect of crenolanib (CP-868596) on phosphorylation of the imatinib-resistant D842V PDGFRA activating mutation associated with advanced gastrointestinal stromal tumors. Heinrich MC, Griffith D, McKinley A, Presnell A, Ramachandran A, ASCO Meeting Abstracts 2011 29 15-suppl 10012
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.15 SUPPL. , pp. 10012
    • Heinrich, M.C.1    Griffith, D.2    McKinley, A.3    Presnell, A.4    Ramachandran, A.5
  • 55
    • 77951878436 scopus 로고    scopus 로고
    • Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST)
    • 10.1016/j.ejca.2010.02.014 20211560
    • Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST). Le Cesne A, Blay JY, Bui BN, Bouche O, Adenis A, Domont J, Cioffi A, Ray-Coquard I, Lassau N, Bonvalot S, et al. Eur J Cancer 2010 46 8 1344 1351 10.1016/j.ejca.2010.02.014 20211560
    • (2010) Eur J Cancer , vol.46 , Issue.8 , pp. 1344-1351
    • Le Cesne, A.1    Blay, J.Y.2    Bui, B.N.3    Bouche, O.4    Adenis, A.5    Domont, J.6    Cioffi, A.7    Ray-Coquard, I.8    Lassau, N.9    Bonvalot, S.10
  • 56
    • 70449707509 scopus 로고    scopus 로고
    • Phase i study of the safety, tolerability, and pharmacokinetics of oral CP-868,596, a highly specific platelet-derived growth factor receptor tyrosine kinase inhibitor in patients with advanced cancers
    • 10.1200/JCO.2009.21.8487 19738123
    • Phase I study of the safety, tolerability, and pharmacokinetics of oral CP-868,596, a highly specific platelet-derived growth factor receptor tyrosine kinase inhibitor in patients with advanced cancers. Lewis NL, Lewis LD, Eder JP, Reddy NJ, Guo F, Pierce KJ, Olszanski AJ, Cohen RB, J Clin Oncol 2009 27 31 5262 5269 10.1200/JCO.2009.21.8487 19738123
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5262-5269
    • Lewis, N.L.1    Lewis, L.D.2    Eder, J.P.3    Reddy, N.J.4    Guo, F.5    Pierce, K.J.6    Olszanski, A.J.7    Cohen, R.B.8
  • 58
    • 26044479980 scopus 로고    scopus 로고
    • A phase I/II trial of the oral mTOR-inhibitor everolimus (E) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM: Study update
    • A phase I/II trial of the oral mTOR-inhibitor everolimus (E) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM: Study update. van Oosterom A, Reichardt P, Blay J-Y, Dumez H, Fletcher J, Debiec-Rychter M, Shand N, Drimitrijevic S, Yap A, Demetri G, ASCO Meeting Abstracts 2005 23 16-suppl 9033
    • (2005) ASCO Meeting Abstracts , vol.23 , Issue.16 SUPPL. , pp. 9033
    • Van Oosterom, A.1    Reichardt, P.2    Blay, J.-Y.3    Dumez, H.4    Fletcher, J.5    Debiec-Rychter, M.6    Shand, N.7    Drimitrijevic, S.8    Yap, A.9    Demetri, G.10
  • 59
    • 78751647387 scopus 로고    scopus 로고
    • Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST
    • Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST. Richter S, Pink D, Hohenberger P, Schuette H, Casali PG, Pustowka A, Reichardt P, ASCO Meeting Abstracts 2010 28 15-suppl 10038
    • (2010) ASCO Meeting Abstracts , vol.28 , Issue.15 SUPPL. , pp. 10038
    • Richter, S.1    Pink, D.2    Hohenberger, P.3    Schuette, H.4    Casali, P.G.5    Pustowka, A.6    Reichardt, P.7
  • 60
    • 74649083444 scopus 로고    scopus 로고
    • Response to sirolimus in combination to tirosine kinase inhibitors (TKI) in three cases of PDGFRA-D842V metastatic gastrointestinal stromal tumor (GIST)
    • Response to sirolimus in combination to tirosine kinase inhibitors (TKI) in three cases of PDGFRA-D842V metastatic gastrointestinal stromal tumor (GIST). Piovesan C, Fumagalli E, Coco P, Palassini E, Dileo P, Morosi C, Gronchi A, Casali P, ASCO Meeting Abstracts 2009 27 15S 10565
    • (2009) ASCO Meeting Abstracts , vol.27 , Issue.15 , pp. 10565
    • Piovesan, C.1    Fumagalli, E.2    Coco, P.3    Palassini, E.4    Dileo, P.5    Morosi, C.6    Gronchi, A.7    Casali, P.8
  • 62
    • 77954214309 scopus 로고    scopus 로고
    • Final results from a Phase III study of IPI504 retaspimycin hydrochloride) versus placebo in patients (pts) with gastrointestinal stromal tumors (GIST) following failure of tyrosine kinase inhibitor (TKI) therapies
    • Final results from a Phase III study of IPI504 retaspimycin hydrochloride) versus placebo in patients (pts) with gastrointestinal stromal tumors (GIST) following failure of tyrosine kinase inhibitor (TKI) therapies. Demetri G, Le Cesne A, von Mehren M, et al. ASCO Gastrointestinal Cancers Symposium Meeting abstracts 2010 28 15-suppl 64
    • (2010) ASCO Gastrointestinal Cancers Symposium Meeting Abstracts , vol.28 , Issue.15 SUPPL. , pp. 64
    • Demetri, G.1    Le Cesne, A.2    Von Mehren, M.3
  • 64
    • 33749461709 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
    • DOI 10.1158/0008-5472.CAN-06-0165
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Bauer S, Yu LK, Demetri GD, Fletcher JA, Cancer Res 2006 66 18 9153 9161 10.1158/0008-5472.CAN-06-0165 16982758 (Pubitemid 44521135)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9153-9161
    • Bauer, S.1    Yu, L.K.2    Demetri, G.D.3    Fletcher, J.A.4
  • 65
    • 37649018967 scopus 로고    scopus 로고
    • Inhibition of the Heat Shock Protein 90 (Hsp90) chaperone with the novel agent IPI-504 to overcome resistance to tyrosine kinase inhibitors (TKIs) in metastatic GIST: Updated results of a phase i trial
    • Inhibition of the Heat Shock Protein 90 (Hsp90) chaperone with the novel agent IPI-504 to overcome resistance to tyrosine kinase inhibitors (TKIs) in metastatic GIST: Updated results of a phase I trial. Demetri GD, George S, Morgan JA, Wagner A, Quigley MT, Polson K, Pokela J, van den Abbeele A, Adams J, Grayzel D, ASCO Meeting Abstracts 2007 25 18-suppl 10024
    • (2007) ASCO Meeting Abstracts , vol.25 , Issue.18 SUPPL. , pp. 10024
    • Demetri, G.D.1    George, S.2    Morgan, J.A.3    Wagner, A.4    Quigley, M.T.5    Polson, K.6    Pokela, J.7    Van Den Abbeele, A.8    Adams, J.9    Grayzel, D.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.