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Simon AE, et al. Ultra high-risk state for psychosis and nontransition: a systematic review. Schizophr Res. 2011;132(1):8-17. This systematic review summarizes available literature on outcomes of those identified as UHR. A total of 31 studies met the inclusion criteria, and on average, 76% (range, 46%-92.6%) of UHR patients made no transition to psychosis during a follow-up period (range, 6-40 months). Characteristics of those who did not transition were poorly investigated. The authors highlight the limited specificity of current UHR criteria and the need for more studies investigating the characteristics associated with nontransition versus transition.
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de Koning MB, et al. Early intervention in patients at ultra high risk of psychosis: benefits and risks. Acta Psychiatr Scand. 2009;119(6):426-42. In this paper, early interventions in patients at UHR for psychosis are reviewed. The authors compiled preliminary publications and unpublished data from the German Research Network on Schizophrenia. Patients from the Bechdolf et al. [58] (2007) cohort who received CBT were found less likely to convert to psychosis or develop a late prodromal state at 1-year follow-up than those who received supportive counseling.
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Liu P, et al. An evidence map of interventions across premorbid, ultra-high risk and first episode phases of psychosis. Schizophr Res. 2010;123(1):37-44. The authors generated an evidence map of controlled trials, meta-analysis, and systematic reviews of biologic and psychosocial interventions in premorbid, UHR, and first-episode patients with psychosis. Most studies in this population involved firstepisode patients, antipsychotic medication trials, and CBT trials. The authors concluded that trials of biologic interventions, other than antipsychotics and psychosocial treatments other than CBT, are lacking and are needed in these patients.
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