Visual acuity is reduced in Alpha 7 nicotinic receptor knockout mice

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 3, 2012, Pages 1211-1218

  Origlia, Nicola ^a   Valenzano, Dario Riccardo ^b   Moretti, Milena ^c   Gotti, Cecilia ^c   Domenici, Luciano ^a,d  

^a CNR   (Italy)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BUNGAROTOXIN RECEPTOR; CHOLERA TOXIN; NICOTINIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTRAST SENSITIVITY; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EVOKED VISUAL RESPONSE; IMMUNOPRECIPITATION; MAZE TEST; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; RETINA; VISION; VISUAL ACUITY; VISUAL CORTEX; VISUAL STIMULATION; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; PHYSIOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EVOKED POTENTIALS, VISUAL; IMMUNOPRECIPITATION; MICE; MICE, KNOCKOUT; RECEPTORS, NICOTINIC; VISUAL ACUITY; VISUAL CORTEX;

EID: 84860616897     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8007     Document Type: Article

References (39)

1. Gotti C, Clementi F. Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol. 2004;74:363-396.
2. Orr-Urtreger A, Goldner FM, Saeki M, et al. Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neurosci. 1997;17:9165-9171.
3. Paylor R, Nguyen M, Crawley JN, Patrick J, Beaudet A, Orr-Urtreger A. Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice. Learn Mem. 1998;5:302-316.
4. Marubio LM, Paylor R. Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors. Neuroscience. 2004;129:575-582.
5. Fernandes C, Hoyle E, Dempster E, Schalkwyk LC, Collier DA. Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav. 2006;5:433-440.
6. Levin ED, Bradley A, Addy N, Sigurani N. Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Neuroscience. 2002;109:757-765.
7. Gotti C, Moretti M, Gaimarri A, Zanardi A, Clementi F, Zoli M. Heterogeneity and complexity of native brain nicotinic receptors. Biochem Pharmacol. 2007;74:1102-1111.
8. Aztiria E, Gotti C, Domenici L. Alpha7 but not alpha4 AChR subunit expression is regulated by light in developing primary visual cortex. J Comp Neurol. 2004;480:378-391.
9. Rossi FM, Pizzorusso T, Porciatti V, Marubio LM, Maffei L, Changeux JP. Requirement of the nicotinic acetylcholine receptor beta 2 subunit for the anatomical and functional development of the visual system. Proc Natl Acad Sci USA. 2001;98:6453-6458.
10. Champtiaux N, Changeux JP. Knock-out and knock-in mice to investigate the role of nicotinic receptors in the central nervous system. Curr Drug Targets CNS Neurol Disord. 2002;1:319-330.
11. Grady SR, Moretti M, Zoli M, et al. Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release. J Neurosci. 2009;29:2272-2282.
12. Moretti M, Mugnaini M, Tessari M, et al. A comparative study of the effects of the intravenous self-administration or subcutaneous minipump infusion of nicotine on the expression of brain neuronal nicotinic receptor subtypes. Mol Pharmacol. 2010;78:287-296.
13. Prusky GT, West PW, Douglas RM. Behavioral assessment of visual acuity in mice and rats. Vision Res. 2000;40:2201-2209.
14. Porciatti V, Pizzorusso T, Maffei L. The visual physiology of the wild type mouse determined with pattern VEPs. Vision Res. 1999; 39:3071-3081.
15. Porciatti V. The mouse pattern electroretinogram. Doc Ophthalmol. 2007;115:145-153.
16. Porciatti V, Saleh M, Nagaraju M. The pattern electroretinogram as a tool to monitor progressive retinal ganglion cell dysfunction in the DBA/2J mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2007;48:745-751.
17. Moretti M, Vailati S, Zoli M, et al. Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience. Mol Pharmacol. 2004;66:85-96.
18. Lipton SA, Kater SB. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends Neurosci. 1989;12:265-270.
19. Role LW, Berg DK. Nicotinic receptors in the development and modulation of CNS synapses. Neuron. 1996;16:1077-1085.
20. Coronas V, Durand M, Chabot JG, Jourdan F, Quirion R. Acetylcholine induces neuritic outgrowth in rat primary olfactory bulb cultures. Neuroscience. 2000;98:213-219.
21. Pugh PC, Berg DK. Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner. J Neurosci. 1994;14:889-896.
22. Zheng JQ, Felder M, Connor JA, Poo MM. Turning of nerve growth cones induced by neurotransmitters. Nature. 1994;368:140-144.
23. Young JW, Finlayson K, Spratt C, et al. Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor. Neuropsychopharmacology. 2004;29:891-900.
24. Young JW, Crawford N, Kelly JS, et al. Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice. Eur Neuropsychopharmacol. 2007;17:145-155.
25. Yu WF, Guan ZZ, Nordberg A. Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice. Neuroscience. 2007;146:1618-1628.
26. Feller MB, Wellis DP, Stellwagen D, Werblin FS, Shatz CJ. Requirement for cholinergic synaptic transmission in the propagation of spontaneous retinal waves. Science. 1996;272:1182-1187.
27. Penn AA, Riquelme PA, Feller MB, Shatz CJ. Competition in retinogeniculate patterning driven by spontaneous activity. Science. 1998;279:2108-2112.
28. Sernagor E, Eglen SJ, O'Donovan MJ. Differential effects of acetylcholine and glutamate blockade on the spatiotemporal dynamics of retinal waves. J Neurosci. 2000;20:RC56(1-6).
29. Bansal A, Singer JH, Hwang BJ, Xu W, Beaudet A, Feller MB. Mice lacking specific nicotinic acetylcholine receptor subunits exhibit dramatically altered spontaneous activity patterns and reveal a limited role for retinal waves in forming ON and OFF circuits in the inner retina. J Neurosci. 2000;20:7672-7681.
30. Pourcho RG. Localization of cholinergic synapses in mammalian retina with peroxidase-conjugated alpha-bungarotoxin. Vision Res. 1979;19:287-292.
31. Heimel JA, Saiepour MH, Chakravarthy S, Hermans JM, Levelt CN. Contrast gain control and cortical TrkB signaling shape visual acuity. Nat Neurosci. 2010;13:642-648.
32. Alkondon M, Pereira EF, Albuquerque EX. Mapping the location of functional nicotinic and gamma-aminobutyric acid A receptors on hippocampal neurons. J Pharmacol Exp Ther. 1996;279:1491-1506.
33. Alkondon M, Rocha ES, Maelicke A, Albuquerque EX. Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release. J Pharmacol Exp Ther. 1996;278:1460-1471.
34. MacDermott AB, Role LW, Siegelbaum SA. Presynaptic ionotropic receptors and the control of transmitter release. Annu Rev Neurosci. 1999;22:443-485.
35. Brocher S, Artola A, Singer W. Agonists of cholinergic and noradrenergic receptors facilitate synergistically the induction of longterm potentiation in slices of rat visual cortex. Brain Res. 1992; 573:27-36.
36. Kirkwood A, Rozas C, Kirkwood J, Perez F, Bear MF. Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine. J Neurosci. 1999;19:1599-1609.
37. Pesavento E, Margotti E, Righi M, Cattaneo A, Domenici L. Blocking the NGF-TrkA interaction rescues the developmental loss of LTP in the rat visual cortex: role of the cholinergic system. Neuron. 2000;25:165-175.
38. Origlia N, Kuczewski N, Aztiria E, Gautam D, Wess J, Domenici L. Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex. J Physiol. 2006;577:829-840.
39. Lepichon JB, Bittel DC, Graf WD, Yu S. A 15q13.3 homozygous microdeletion associated with a severe neurodevelopmental disorder suggests putative functions of the TRPM1, CHRNA7, and other homozygously deleted genes. Am J Med Genet A. 2010;152A: 1300-1304.