CPSI-121 pharmacologically prevents intestinal barrier dysfunction after cutaneous burn through a vagus nerve-dependent mechanism

Journal of Trauma and Acute Care Surgery

Volumn 72, Issue 2, 2012, Pages 355-363

  Krzyzaniak, Michael ^a   Ortiz Pomales, Yan ^a   Lopez, Nicole ^a   Reys, Luiz Guilherme ^a   Cheadle, Gerald ^c   Wolf, Paul ^b   Eliceiri, Brian ^a   Bansal, Vishal ^a   Baird, Andrew ^a   Coimbra, Raul ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE

Author keywords

Burn; Guanylhydrazone; Gut injury; Intestinal barrier; Tight junction; Trauma

Indexed keywords

AMIDINOHYDRAZONE; CPSI 121; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; PROTEIN ZO1; UNCLASSIFIED DRUG; CPSI-121; HYDRAZONE DERIVATIVE; MEMBRANE PROTEIN; OCCLUDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; BURN; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DIGESTIVE SYSTEM FUNCTION DISORDER; DRUG EFFICACY; DRUG MECHANISM; INTESTINAL BARRIER DYSFUNCTION; INTESTINE MUCOSA PERMEABILITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH INJURY; TIGHT JUNCTION; VAGOTOMY; VAGUS NERVE STIMULATION; ANALYSIS OF VARIANCE; ANIMAL; BAGG ALBINO MOUSE; CONFOCAL MICROSCOPY; DRUG EFFECT; IMMUNOBLOTTING; INTESTINE MUCOSA; METABOLISM; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PERMEABILITY; VAGUS NERVE;

ANALYSIS OF VARIANCE; ANIMALS; BURNS; HYDRAZONES; IMMUNOBLOTTING; INTESTINAL MUCOSA; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; PERMEABILITY; STATISTICS, NONPARAMETRIC; VAGUS NERVE; VAGUS NERVE STIMULATION;

EID: 84860579937     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31824484fe     Document Type: Article

References (21)

1. Deitch EA. Role of the gut lymphatic system in multiple organ failure. Curr Opin Crit Care. 2001;7:92-98.
2. Mainous MR, Ertel W, Chaudry IH, Deitch EA. The gut: a cytokinegenerating organ in systemic inflammation? Shock. 1995;4:193-199.
3. Moore FA. The role of the gastrointestinal tract in postinjury multiple organ failure. Am J Surg. 1999;178:449-453.
4. Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405:458-462.
5. Wang H, Yu M, Ochani M, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003;421:384-388.
6. Rosas-Ballina M, Ochani M, Parrish WR, et al. Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia. Proc Natl Acad Sci USA. 2008;105:11008-11013.
7. Huston J, Ochani M, Rosas-Ballina M, et al. Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med. 2006;203:1623-1628.
8. Costantini TW, Bansal V, Krzyzaniak M, et al. Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells. Am J Physiol Gastrointest Liver Physiol. 2010;299: GI1308-GI1318.
9. Krzyzaniak M, Peterson CY, Cheadle G, et al. Efferent vagal nerve stimulation attenuates acute lung injury following burn: the importance of the gut-lung axis. Surgery. 2011;150:379-389.
10. Costantini TW, Bansal V, Peterson CY, et al. Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression. J Trauma. 2010;68:1349-1354; discussion 1354-1356.
11. Krzyzaniak M, Peterson C, Loomis W, et al. Postinjury vagal nerve stimulation protects against intestinal epithelial barrier breakdown. J Trauma. 2010;70:1168-1175; discussion 1175-1176.
12. Tracey KJ. Suppression of TNF and other proinflammatory cytokines by the tetravalent guanylhydrazone CNI-1493. Prog Clin Biol Res. 1998; 397:335-343.
13. Borovikova LV, Ivanova S, Nardi D, et al. Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton Neurosci. 2000;85:141-147.
14. Bernik TR, Friedman SG, Ochani M, et al. Pharmacological stimulation of the cholinergic antiinflmammatory pathway. J Exp Med. 2002;195: 781-788.
15. Walker HL, Mason AD Jr. A standard animal burn. J Trauma. 1968;8: 1049-1051.
16. Bansal V, Costantini T, Kroll L, et al. Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis. J Neurotrauma. 2009;26: 1353-1359.
17. Atkins MB, Redman B, Mier J, et al. A phase I study of CNI-1493, an inhibitor of cytokine release, in combination with high-dose interleukin-2 in patients with renal cancer and melanoma. Clin Cancer Res. 2001;7:486-492.
18. Dotan I, Rachmilewitz D, Schreiber S, et al; Semapimod-CD04/CD05 Investigators. A randomized placebo-controlled multicentre trial of intravenous semapimod HCI for moderate to severe Crohn's disease. Gut. 2010;59:760-766.
19. Deree J, de Campos T, Shenvi E, Loomis WH, Hoyt DB, Coimbra R. Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation. J Trauma. 2007;62:818-827; discussion 827-828.
20. Costantini TW, Peterson CY, Kroll L, et al. Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategy. J Trauma. 2009;67:1162-1168.
21. Costantini TW, Loomis WH, Putnam JG, et al. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock. 2009;31:416-422.