Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

Epigenetics

Volumn 7, Issue 4, 2012, Pages 340-343

  van Aller, Glenn S ^a   Reynoird, Nicolas ^b   Barbash, Olena ^a   Huddleston, Michael ^a   Liu, Shichong ^c   Zmoos, Anne Flore ^d   McDevitt, Patrick ^a   Sinnamon, Robert ^a   Le, BaoChau ^a   Mas, Gloria ^b   Annan, Roland ^a   Sage, Julien ^d   Garcia, Benjamin A ^c   Tummino, Peter J ^a   Gozani, Or ^b   Kruger, Ryan G ^a  

^a GLAXOSMITHKLINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c PRINCETON UNIVERSITY   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer Smyd3; Epigenetics; Lysine; Methylation; Oncogene; Oncology

Indexed keywords

HISTONE H3; HISTONE H4; HISTONE LYSINE METHYLTRANSFERASE; SMYD3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CANCER CELL; CATALYSIS; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; HISTONE METHYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TANDEM MASS SPECTROMETRY;

EID: 84860549203     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.19506     Document Type: Article

References (10)

1. Kouzarides T. Chromatin modifications and their function. Cell 2007; 128:693-705 PMID:17320507; http://dx.doi.org/10.1016/j.cell.2007.02.005.
2. Shi Y, Whetstine JR. Dynamic regulation of histone lysine methylation by demethylases. Mol Cell 2007; 25:1-14 PMID:17218267; http://dx.doi.org/10.1016/j.molcel.2006.12.010.
3. Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, et al. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell 2011; 44:609-20 PMID:22099308; http://dx.doi.org/10.1016/j.molcel.2011.08.042.
4. Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010; 42:181-5 PMID:20081860; http://dx.doi.org/10.1038/ng.5185.
5. Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, et al. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol 2004; 6:731-40 PMID:15235609; http://dx.doi.org/10.1038/ncb1151.
6. Hamamoto R, Silva FP, Tsuge M, Nishidate T, Katagiri T, Nakamura Y, et al. Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Sci 2006; 97:113-8 PMID:16441421; http://dx.doi.org/10.1111/j.1349-7006.2006.00146.x.
7. Wang SZ, Luo XG, Shen J, Zou JN, Lu YH, Xi T. Knockdown of SMYD3 by RNA interference inhibits cervical carcinoma cell growth and invasion in vitro. BMB Rep 2008; 41:294-9 PMID:18452649; http://dx.doi.org/10.5483/BMBRep.2008.41.4.294.
8. Foreman KW, Brown M, Park F, Emtage S, Harriss J, Das C, et al. Structural and functional profiling of the human histone methyltransferase SMYD3. PLoS One 2011; 6:22290 PMID:21779408; http://dx.doi.org/10.1371/journal.pone.0022290
9. Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, et al. Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol 2002; 12:1086-99; PMID:12121615; http://dx.doi.org/10.1016/S0960-9822(02)00924-7.
10. Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, et al. PR-Set7 is a nucleosomespecific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell 2002; 9:1201-13 PMID:12086618; http://dx.doi.org/10.1016/S1097-2765(02)00548-8.