Stabilisation and encapsulation of protein into biodegradable microspheres with zinc ion and protein in polyethylene glycol solution formed nanoparticles by freeze-drying

Micro and Nano Letters

Volumn 7, Issue 3, 2012, Pages 215-218

  Ma, Liuqing ^a,b   Hong, Xiaoyun ^b   Liu, Zhenguo ^a   Yuan, Weien ^b  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMINS; BURST RELEASE; ENCAPSULATION OF PROTEINS; IN-VITRO; PLGA MICROSPHERES; POLY-LACTIDE-CO-GLYCOLIDE; PREPARATION PROCESS; SUSTAINED-RELEASE; UNSOLVED PROBLEMS; ZINC IONS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONS; LOW TEMPERATURE DRYING; MICROSPHERES; NANOPARTICLES; POLYETHYLENE GLYCOLS; ZINC;

PROTEINS;

BOVINE SERUM ALBUMIN; MACROGOL; MICROSPHERE; NANOPARTICLE; POLYGLACTIN; ZINC ACETATE; ZINC ION;

ARTICLE; BIODEGRADABILITY; EMULSION; ENCAPSULATION; FREEZE DRYING; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN STABILITY; SUSTAINED DRUG RELEASE;

EID: 84860523388     PISSN: None     EISSN: 17500443     Source Type: Journal    
DOI: 10.1049/mnl.2011.0640     Document Type: Article

References (21)

1. Wang, W.: ' Instability, stabilization, and formulation of liquid protein pharmaceuticals ', Int. J. Pharm., 1999, 185, p. 129-188 10.1016/S0378-5173(99) 00152-0
2. Grenha, A., Seijo, B., and Remuñán-López, C.: ' Microencapsulated chitosan nano-particles for lung protein delivery ', Eur. J. Pharm. Sci., 2005, 25, (4), p. 427-437 10.1016/j.ejps.2005.04.009
3. Cheng, Y.-H., Dyer, A.M., and Jabbal-Gill, I.: et al. ' Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations ', Eur. J. Pharm. Sci., 2005, 26, (1), p. 9-15 10.1016/j.ejps.2005.03.014
4. Yoo, J.-W., Doshi, N., and Mitragotri, S.: ' Adaptive micro and nanoparticles: temporal control over carrier properties to facilitate drug delivery ', Adv. Drug Deliv. Rev., 2011, 63, (14-15), p. 1247-1256 10.1016/j.addr.2011.05.004
5. Frokjaer, S., and Otzen, D.E.: ' Protein drug stability: a formulation challenge ', Nat. Rev. Drug Discov., 2005, 4, (4), p. 298-306 10.1038/nrd1695
6. Yang, S., Yuan, W., and Jin, T.: ' Formulating protein therapeutics into particulate forms ', Expert Opin. Drug Deliv., 2009, 6, (10), p. 1123-1133 10.1517/17425240903156374
7. Yuan, W., Wu, F., Guo, M., and Jin, T.: ' Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion ', Eur. J. Pharm. Sci., 2009, 36, (2-3), p. 212-218 10.1016/j.ejps.2008.08.009
8. Yuan, W., Geng, Y., and Wu, F.: et al. ' Preparation of polysaccharide glassy microparticles with stabilization of proteins ', Int. J. Pharm., 2009, 366, p. 154-159 10.1016/j.ijpharm.2008.09.007
9. Rong, X., Mo, X., and Ren, T.: et al. ' Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats ', Eur. J. Pharm. Sci., 2011, 43, (4), p. 334-342 10.1016/j.ejps.2011.05.011
10. Ren, T., Yuan, W., Zhao, H., and Jin, T.: ' Sustained-release polylactide-co-glycolide microspheres loaded with pre-formulated protein polysaccharide nanoparticles ', Micro. Nano. Lett., 2011, 6, (2), p. 70-74 10.1049/mnl.2010.0107
11. Johnson, O.L., Cleland, J.L., and Lee, H.J.: et al. ' A month-long effect form a single injection of microencapsulated human growth hormone ', Nat. Med., 1996, 2, p. 795-799 10.1038/nm0796-795
12. Johnson, O.L., Jaworowicz, W., and Cleland, J.L.: et al. ' The stabilization and encapsulation of human growth hormone into biodegradable microspheres ', Pharm. Res., 1997, 14, p. 730-735 10.1023/A:1012142204132
13. Morita, T., Sakamura, Y., and Horikiri, Y.: et al. ' Protein encapsulation into biodegradable microspheres by a novel S/O/W emulsion method using poly(ethylene glycol) as a protein micronization adjuvant ', J. Control. Rel., 2000, 69, (3), p. 435-444 10.1016/S0168-3659(00)00326-6
14. Carrasquillo, K.G., Staneley, A.M., and Aponte Carro, J.C.: et al. ' Non-aqueous encapsulation of excipient-stabilized spray-dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein ', J. Control. Rel., 2001, 76, (3), p. 199-208 10.1016/S0168-3659(01)00430-8
15. Branchu, S., Forbes, R.T., and York, P.: et al. ' Hydroxypropyl-beta- cyclodextrin inhibits spray-drying-induced inactivation of beta-galactosidase ', J. Pharm. Sci., 1999, 88, p. 905-911 10.1021/js9804819
16. Tzannis, S.T., and Prestrelski, S.J.: ' Activity-stability considerations of trypsinogen during spray drying: effects of sucrose ', J. Pharm. Sci., 1999, 88, p. 351-359 10.1021/js980011e
17. Moshashaee, S., Bisrat, M., and Forbes, R.T.: et al. ' Supercritical fluid processing of proteins. I: lysozyme precipitation from organic solution ', Eur. J. Pharm. Sci., 2000, 11, p. 239-245 10.1016/S0928-0987(00)00108-1
18. Wang, J., Chua, K.M., and Wang, C.-H.: ' Stabilization and encapsulation of human immunoglobulin G into biodegradable microspheres ', J. Colloid. Interf. Sci., 2004, 271, (1), p. 92-101 10.1016/j.jcis.2003.08.072
19. 2+ nanoparticles under mild conditions ', Nanotechnology, 2007, 18, (14), p. 145601-145608 10.1088/0957-4484/18/14/ 145601 0957-4484
20. Sah, H.: ' Stabilization of proteins against methylene chloride/water interface-induced denaturation and aggregation ', J. Control. Rel., 1999, 58, p. 143-151 10.1016/S0168-3659(98)00148-5
21. Wong, H.M., Wang, J.J., and Wang, C.-H.: ' In vitro sustained release of human immunoglobulin G from biodegradable microspheres ', Ind. Eng. Chem. Res., 2001, 40, (3), p. 933-948 10.1021/ie0006256 0888-5885