Caveolin-1 Regulates Mcl-1 Stability and Anoikis in Lung Carcinoma Cells

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 9, 2012, Pages

  Chunhacha, Preedakorn ^a   Pongrakhananon, Varisa ^b   Rojanasakul, Yon ^c   Chanvorachote, Pithi ^b  

^a Pharmaceutical Technology (International) Program   (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Anoikis resistance; Lung cancer; Metastasis; Myeloid cell leukemia 1

Indexed keywords

CAVEOLIN 1; PROTEASOME; PROTEIN MCL 1; UBIQUITIN;

ANOIKIS; ARTICLE; CARCINOMA CELL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; INHIBITION KINETICS; LUNG CANCER; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MELANOMA CELL; METASTASIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; UBIQUITINATION; WESTERN BLOTTING;

ANOIKIS; BLOTTING, WESTERN; CAVEOLIN 1; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LUNG NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84860521179     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00318.2011     Document Type: Article

References (32)

1. Boisvert AK, Longmate W, Abel EV, Aplin AE. Mcl-1 is required for melanoma cell resistance to anoikis. Mol Cancer Res 7: 549-556, 2009.
2. Chanvorachote P, Nimmannit U, Lu Y, Talbott S, Jiang BH, Rojana-sakul Y. Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1. J Biol Chem 284: 28476-28484, 2009.
3. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ. Bcl-2 and Bcl-xL sequester BH3 domain-only molecule preventing Bax and Bak-mediated mitochondrial apoptosis. Mol Cell 8: 705-711, 2001.
4. Chiarugi P, Giannoni E. Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol 76: 1352-1364, 2008.
5. Corn PG, Thompson TC. Identification of a novel prostate cancer biomarker, caveolin-1: implications and potential clinical benefit. Cancer Manag Res 2: 111-122, 2010.
6. Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, Lisanti MP. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett 428: 205-211, 1998.
7. Fiucci G, Ravid D, Reich R, Liscovitch M. Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 21: 2365-2375, 2002.
8. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124: 619-626, 1994.
9. Glickman MH, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82: 373-428, 2002.
10. Ho CC, Kuo SH, Huang PH, Huang HY, Yang CH, Yang PC. Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy. Lung Cancer 59: 105-110, 2007.
11. Hurlstone AF, Reid G, Reeves JR, Fraser J, Strathdee G, Rahilly M, Parkinson EK, Black DM. Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Oncogene 18: 1881-1890, 1999.
12. Hynes RO. Cell adhesion: old and new questions. Trends Cell Biol 9: M33-M37, 1999.
13. Keuling AM, Felton KE, Parker AA, Akbari M, Andrew SE, Tron VA. RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway. PLoS One 4: e6651, 2009.
14. Lajoie P, Nabi IR. Lipid rafts, caveolae, and their endocytosis. Int Rev Cell Mol Biol 282: 135-136, 2010.
15. Li L, Ren CH, Tahir SA, Ren C, Thompson TC. Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phospha-tases PP1 and PP2A. Mol Cell Biol 23: 9389-9404, 2003.
16. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001.
17. Lloyd PG. Caveolin-1, antiapoptosis signaling, and anchorage-independent cell growth. Focus on "Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells." Am J Physiol Cell Physiol (March 14, 2012). doi:10.1152/ajpcell.00075.2012.
18. Luanpitpong S, Talbott SJ, Rojanasakul Y, Nimmannit U, Pongra-khananon V, Wang L, Chanvorachote P. Regulation of lung cancer cell migration and invasion by reactive oxygen species and caveolin-1. J Biol Chem 285: 38832-38840, 2010.
19. Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 21: 749-760, 2006.
20. Michels J, Johnson PW, Packham G. Mcl-1. Int J Biochem Cell Biol 37: 267-271, 2005.
21. Nakashima H, Hamamura K, Houjou T, Taguchi R, Yamamoto N, Mitsudo K, Tohnai I, Ueda M, Urano T, Furukawa K. Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties. Cancer Sci 98: 512-520, 2007.
22. Quest AF, Leyton L, Párraga M. Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease. Biochem Cell Biol 82: 129-144, 2004.
23. Racine C, Belanger M, Hirabayashi H, Boucher M, Chakir J, Couet J. Reduction of caveolin 1 gene expression in lung carcinoma cell lines. Biochem Biophys Res Commun 255: 580-586, 1999.
24. Rungtabnapa P, Nimmannit U, Halim H, Rojanasakul Y, Chanvora-chote P. Hydrogen peroxide inhibits non-small cell lung cancer cell anoikis through the inhibition of caveolin-1 degradation. Am J Physiol Cell Physiol 300: C235-C245, 2011.
25. Simpson CD, Anyiwe K, Schimmer AD. Anoikis resistance and tumor metastasis. Cancer Lett 272: 177-185, 2008.
26. Song L, Coppola D. Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells. Cancer Biol Ther 4: 267-276, 2005.
27. Tang Y, Zeng X, He F, Liao Y, Qian N, Toi M. Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer. Med Oncol. In press.
28. Thompson TC, Tahir SA, Li L, Watanabe M, Naruishi K, Yang G, Kadmon D, Logothetis CJ, Troncoso P, Ren C, Goltsov A, Park S. The role of caveolin-1 in prostate cancer: clinical implications. Prostate Cancer Prostatic Dis 13: 6-11, 2010.
29. Woods NT, Yamaguchi H, Lee FY, Bhalla KN, Wang HG. Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis. Cancer Res 67: 10744-10752, 2007.
30. Yeh D, Chen C, Sun MZ, Shao S, Hao L, Song Y, Gong L, Hu J, Wang Q. Caveolin-1 is an important factor for the metastasis and proliferation of human small cell lung cancer NCI-H446 cell. Anat Rec 292: 1584-1592, 2009.
31. Zhang H, Guttikonda S, Roberts L, Uziel T, Semizarov D, Elmore SW, Leverson JD, Lam LT. Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines. Oncogene 30: 1963-1968, 2011.
32. Zhang S, Zhau HE, Osunkoya AO, Iqbal S, Yang X, Fan S, Chen Z, Wang R, Marshall FF, Chung LW, Wu D. Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells. Mol Cancer 9: 9, 2010.