The acinetobacter baumannii enta gene located outside the acinetobactin cluster is critical for siderophore production, iron acquisition and virulence

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Penwell, William F ^a   Arivett, Brock A ^a   Actis, Luis A ^a  

^a MIAMI UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; ACINETOBACTIN; AMINO ACID; ARYL CARRIER PROTEIN; BACTERIAL PROTEIN; CARRIER PROTEIN; IRON; ISOCHORISMATASE LYASE; ISOCHORISMIC ACID; PROTEIN ENTB; SIDEROPHORE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTION; ACINETOBACTIN GENE; AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BASF GENE; BIOSYNTHESIS; COMPUTER MODEL; CONTROLLED STUDY; ENTA GENE; ENTB GENE; EX VIVO STUDY; GENE CLUSTER; GENE DUPLICATION; GENE LOCATION; HORIZONTAL GENE TRANSFER; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROBIAL ACTIVITY; MOLECULAR CLONING; NONHUMAN; ORTHOLOGY; PROTEIN DOMAIN;

ACINETOBACTER BAUMANNII; CHROMOSOMES, BACTERIAL; CLONING, MOLECULAR; GENE ORDER; GENES, BACTERIAL; GENETIC LOCI; IMIDAZOLES; IRON; MOLECULAR SEQUENCE ANNOTATION; MULTIGENE FAMILY; OXAZOLES; PHENOTYPE; SIDEROPHORES; VIRULENCE;

ACINETOBACTER BAUMANNII; BACTERIA (MICROORGANISMS);

EID: 84860505036     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036493     Document Type: Article

References (52)

1. Anstey NM, Currie BJ, Withnall KM, (1991) Community-acquired Acinetobacter pneumonia in the northern territory of Australia. Clin Infect Dis 14: 83-91.
2. Bergogne-Berezin E, Towner KJ, (1996) Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin Microbiol Rev 9: 148-165.
3. Dijkshoorn L, Nemec A, Seifert H, (2007) An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol 5: 939-951.
4. Peleg AY, Seifert H, Paterson DL, (2008) Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev 21: 538-582.
5. CDC (2004) Acinetobacter baumannii infections among patients at military medical facilities treating U.S. service members, 2002-2004. MMWR 53: 1063-1066.
6. Davis KA, Moran KA, McAllister CK, Gray PJ, (2005) Multidrug-resistant Acinetobacter extremity infections in soldiers. Emerg Infect Dis 11: 1218-1224.
7. Charnot-Katsikas A, Dorafshar AH, Aycock JK, David MZ, Weber SG, et al. (2009) Two cases of necrotizing fasciitis due to Acinetobacter baumannii. J Clin Microbiol 47: 258-263.
8. Crichton R, (2009) Iron metabolism. From molecular mechanisms to clinical consequences West Sussex, United Kingdom John Wiley & Sons Ltd.
9. Weinberg ED, (2009) Iron availability and infection. Biochim Biophys Acta 1790: 600-605.
10. Crosa JH, Mey AR, Payne SM, (2004) Iron transport in bacteria Washington, D.C. ASM Press.
11. Wandersman C, Delepelaire P, (2004) Bacterial iron sources: from siderophores to hemophores. Annu Rev Microbiol 58: 611-647.
12. Dorsey CW, Beglin MS, Actis LA, (2003) Detection and analysis of iron uptake components expressed by Acinetobacter baumannii clinical isolates. J Clin Microbiol 41: 4188-4193.
13. Dorsey CW, Tolmasky ME, Crosa JH, Actis LA, (2003) Genetic organization of an Acinetobacter baumannii chromosomal region harbouring genes related to siderophore biosynthesis and transport. Microbiology 149: 1227-1238.
14. Dorsey CW, Tomaras AP, Connerly PL, Tolmasky ME, Crosa JH, et al. (2004) The siderophore-mediated iron acquisition systems of Acinetobacter baumannii ATCC 19606 and Vibrio anguillarum 775 are structurally and functionally related. Microbiology 150: 3657-3667.
15. Echenique JR, Arienti H, Tolmasky ME, Read R, Staneloni J, et al. (1992) Characterization of a high-affinity iron transport system in Acinetobacter baumannii. J Bacteriol 174: 7670-7679.
16. Antunes LC, Imperi F, Towner KJ, Visca P, (2011) Genome-assisted identification of putative iron-utilization genes in Acinetobacter baumannii and their distribution among a genotypically diverse collection of clinical isolates. Res Microbiol 162: 279-284.
17. Eijkelkamp BA, Hassan KA, Paulsen IT, Brown MH, (2011) Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions. BMC Genomics 12: 126.
18. Mihara K, Tanabe T, Yamakawa Y, Funahashi T, Nakao H, et al. (2004) Identification and transcriptional organization of a gene cluster involved in biosynthesis and transport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC 19606T. Microbiology 150: 2587-2597.
19. Yamamoto S, Okujo N, Sakakibara Y, (1994) Isolation and structure elucidation of acinetobactin, a novel siderophore from Acinetobacter baumannii. Arch Microbiol 162: 249-252.
20. Earhart CF, (1996) Uptake and metabolism of iron and molybdenum. In: Neidhardt FC, editors. Escherichia coli and Salmonella Cellular and Molecular Biology. Second edition ed Washington, DC American Society for Microbiology pp. 1075-1090.
21. Walsh CT, Liu J, Rusnak F, Sakaitani M, (1990) Molecular studies on enzymes in chorismate metabolism and enterobactin biosynthetic pathway. Chem Rev 90: 1105-1129.
22. Sambrook J, Russell DW, (2001) Molecular Cloning. A Laboratory Manual Cold Spring Harbor, N. Y. Cold Spring Harbor Laboratory Press.
23. Meade HM, Long SR, Ruvkum GB, Brown SE, Ausubel FM, (1982) Physical and genetic characterization of symbiotic and auxotrophic mutants Rhizobium meliloti induced by transposon Tn5 mutagenesis. J Bacteriol 149: 114-122.
24. Feinberg AP, Vogelstein B, (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132: 6-13.
25. Yanisch-Perron C, Vieira J, Messing J, (1985) Improved M13phage cloning vectors and host strains: nucleotide sequence of the M13mp18 and pUC19 vectors. Gene 33: 103-109.
26. Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
27. Dorsey CW, Tomaras AP, Actis LA, (2002) Genetic and phenotypic analysis of Acinetobacter baumannii insertion derivatives generated with a Transposome system. Appl Environ Microbiol 68: 6353-6360.
28. Schwyn B, Neilands JB, (1987) Universal chemical assay for the detection and determination of siderophores. Anal Biochem 160: 47-56.
29. Arnow L, (1937) Colorimetric determination of the components of 3,4-dihydroxyphenylalanine-tyrosine mixtures. J Biol Chem 118: 531-537.
30. Miller J, (1972) Experiments in molecular genetics Cold spring Harbor, N.Y. Cold Spring Harbor Laboratory.
31. Staab JF, Earhart CF, (1990) EntG activity of Escherichia coli enterobactin synthetase. J Bacteriol 172: 6403-6410.
32. Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G, (1976) A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 17: 62-70.
33. Gaddy JA, Tomaras AP, Actis LA, (2009) The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and the interaction of this pathogen with eukaryotic cells. Infect Immun 77: 3150-3160.
34. Peleg AY, Jara S, Monga D, Eliopoulos GM, Moellering RC Jr, et al. (2009) Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics. Antimicrob Agents Chemother 53: 2605-2609.
35. Kaplan EL, Meier P, (1958) Nonparametric estimation from incomplete data. J Amer Statist Assn 53: 457-481.
36. Vallenet D, Nordmann P, Barbe V, Poirel L, Mangenot S, et al. (2008) Comparative analysis of Acinetobacters: three genomes for three lifestyles. PLoS ONE 3: e1805.
37. Adams MD, Goglin K, Molyneaux N, Hujer KM, Lavender H, et al. (2008) Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J Bacteriol 190: 8053-8064.
38. Iacono M, Villa L, Fortini D, Bordoni R, Imperi F, et al. (2008) Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group. Antimicrob Agents Chemother 52: 2616-2625.
39. Smith MG, Gianoulis TA, Pukatzki S, Mekalanos JJ, Ornston LN, et al. (2007) New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes Dev 21: 601-614.
40. Zimbler DL, Penwell WF, Gaddy JA, Menke SM, Tomaras AP, et al. (2009) Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii. Biometals 22: 23-32.
41. Alice AF, Lopez CS, Crosa JH, (2005) Plasmid- and chromosome-encoded redundant and specific functions are involved in biosynthesis of the siderophore anguibactin in Vibrio anguillarum 775: a case of chance and necessity? J Bacteriol 187: 2209-2214.
42. Di Lorenzo M, Stork M, Tolmasky ME, Actis LA, Farrell D, et al. (2003) Complete sequence of virulence plasmid pJM1 from the marine fish pathogen Vibrio anguillarum strain 775. J Bacteriol 185: 5822-5830.
43. Naka H, Lopez CS, Crosa JH, (2008) Reactivation of the vanchrobactin siderophore system of Vibrio anguillarum by removal of a chromosomal insertion sequence originated in plasmid pJM1 encoding the anguibactin siderophore system. Environ Microbiol 10: 265-277.
44. Snitkin ES, Zelazny AM, Montero CI, Stock F, Mijares L, et al. (2011) Genome-wide recombination drives diversification of epidemic strains of Acinetobacter baumannii. Proc Natl Acad Sci USA 108: 13758-13763.
45. Naka H, Crosa JH, (2012) Identification and characterization of a novel outer membrane protein receptor FetA for ferric enterobactin transport in Vibrio anguillarum 775 (pJM1). Biometals 25: 125-133.
46. Zhou Z, Lai JR, Walsh CT, (2007) Directed evolution of aryl carrier proteins in the enterobactin synthetase. Proc Natl Acad Sci USA 104: 11621-11626.
47. Di Lorenzo M, Stork M, Crosa JH, (2011) Genetic and biochemical analyses of chromosome and plasmid gene homologues encoding ICL and ArCP domains in Vibrio anguillarum strain 775. Biometals 24: 629-643.
48. Drake EJ, Nicolai DA, Gulick AM, (2006) Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain. Chem Biol 13: 409-419.
49. Barbe V, Vallenet D, Fonknechten N, Kreimeyer A, Oztas S, et al. (2004) Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium. Nucleic Acids Res 32: 5766-5779.
50. Kavanagh K, Reeves EP, (2004) Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens. FEMS Microbiol Rev 28: 101-112.
51. Bellaire BH, Elzer PH, Baldwin CL, Roop RM 2nd, (2003) Production of the siderophore 2,3-dihydroxybenzoic acid is required for wild-type growth of Brucella abortus in the presence of erythritol under low-iron conditions in vitro. Infect Immun 71: 2927-2932.
52. Parent MA, Bellaire BH, Murphy EA, Roop RM 2nd, Elzer PH, et al. (2002) Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria. Microb Pathog 32: 239-248.