Obesity as the initial manifestation of central nervous system relapse of acute lymphoblastic leukemia: Case report and literature review

Journal of Cancer Research and Therapeutics

Volumn 8, Issue 1, 2012, Pages 151-153

  Zhang, Li Dan ^a   Li, Yan Hong ^a   Ke, Zhi Yong ^a   Huang, Li Bin ^a   Luo, Xue Qun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Central nervous system leukemia; childhood; obesity

Indexed keywords

DEXAMETHASONE; METHOTREXATE;

ACANTHOSIS NIGRICANS; ACNE; ACUTE LYMPHOBLASTIC LEUKEMIA; BODY MASS; CANCER CHEMOTHERAPY; CANCER REGRESSION; CANCER RELAPSE; CASE REPORT; CENTRAL NERVOUS SYSTEM LEUKEMIA; CENTRAL NERVOUS SYSTEM TUBERCULOSIS; CEREBROSPINAL FLUID ANALYSIS; CHILD; EMOTIONAL DISORDER; FLOW CYTOMETRY; HEADACHE; HEPATOMEGALY; HUMAN; HYPERPHAGIA; INSULIN RESISTANCE; LUMBAR PUNCTURE; LYMPHOBLAST; MALE; MICROSCOPY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; REVIEW; SCHOOL CHILD; TESTIS; TREATMENT RESPONSE; WEIGHT GAIN;

BRAIN; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD; HUMANS; INDUCTION CHEMOTHERAPY; MAGNETIC RESONANCE IMAGING; MALE; OBESITY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECURRENCE; TREATMENT OUTCOME;

EID: 84860475902     PISSN: 09731482     EISSN: 19984138     Source Type: Journal    
DOI: 10.4103/0973-1482.95200     Document Type: Review

References (12)

1. Laningham FH, Kun LE, Reddick WE, Ogg RJ, Morris EB, Pui CH. Childhood central nervous system leukemia: Historical perspectives, current therapy, and acute neurological sequelae. Neuroradiology 2007;49:873-88. (Pubitemid 350104848)
2. Stewart DJ, Keating MJ, McCredie KB, Smith TL, Youness E, Murphy SG, et al. Natural history of central nervous system acute leukemia in adults. Cancer 1981;47:184-96. (Pubitemid 11167379)
3. Luo XQ, Ke ZY, Guan XQ, Zhang YC, Huang LB, Zhu J. The comparison of outcome and cost of three protocols for childhood non-high risk acute lymphoblastic leukemia in China. Pediatr Blood Cancer 2008;51:204-9. (Pubitemid 351874414)
4. Bürger B, Zimmermann M, Mann G, Kühl J, Löning L, Riehm H, et al. Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: Significance of low leukocyte counts with blasts or traumatic lumbar puncture. J Clin Oncol 2003;21:184-8. (Pubitemid 46606145)
5. Barak Y, Liban E. Hypothalamic hyperphagia, obesity and disturbed behaviour in acute leukemia. Acta Paediatr Scand 1968;57:153-6.
6. Lustig RH. Hypothalamic obesity: The sixth cranial endocrinopathy. Endocrinologist 2002;12:210-7. (Pubitemid 34602855)
7. Pinkney J, Wilding J, Williams G, MacFarlane I. Hypothalamic obesity Figure 2: CSF fl ow cytometry analysis showed the blasts (arrow) were positive for CD22, CD10, CD34, HLA-DR, CD19, and CD79a in humans: What do we know and what can be done? Obes Rev 2002;3:27-34.
8. Danon M, Beckman EN, Kase JC, Toch R, Crawford JD. Cushing's syndrome and acute lymphoblastic leukemia. Am J Dis Child 1978;132:888-92. (Pubitemid 9140071)
9. Mastorakos G, Zapanti E. The hypothalamic-pituitary-adrenal axis in the neuroendocrine regulation of food intake and obesity: The role of corticotropin releasing hormone. Nutr Neurosci 2004;7:271-80. (Pubitemid 40123777)
10. Ra'anani P, Shpilberg O, Berezin M, Ben-Bassat I. Acute leukemia relapse presenting as central diabetes insipidus. Cancer 1994;73:2312-6. (Pubitemid 24129113)
11. Indira B, Panigrahi MK, Vajramani G, Shankar SK, Santosh V, Das BS. Tuberculoma of the hypothalamic region as a rare case of hypopituitarism: A case report. Surg Neurol 1996;45:347-50. (Pubitemid 26117243)
12. Bromberg JE, Breems DA, Kraan J, Bikker G, van der Holt B, Smitt PS, et al. CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies. Neurology 2007;68:1674-9. (Pubitemid 46763254)