Transcriptional inhibition of p21 WAF1/CIP1 gene (CDKN1) expression by survivin is at least partially p53-dependent: Evidence for survivin acting as a transcription factor or co-factor

Biochemical and Biophysical Research Communications

Volumn 421, Issue 2, 2012, Pages 249-254

  Tang, Lei ^a,b   Ling, Xiang ^a   Liu, Wensheng ^a   Das, Gokul M ^a   Li, Fengzhi ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Cancer cells; P21 promoter activity; P21 WAF1 CIP1; P53; Survivin

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; PROTEIN P53; SHORT HAIRPIN RNA; SURVIVIN; TRANSCRIPTION FACTOR; BIRC5 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; INHIBITOR OF APOPTOSIS PROTEIN;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; CDKN1 GENE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LENTIVIRINAE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; UPREGULATION; WILD TYPE; BIOSYNTHESIS; DRUG ANTAGONISM; GENETICS; METABOLISM; PROMOTER REGION; PROTEIN BINDING; TUMOR CELL LINE;

CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G1 PHASE; GENE EXPRESSION REGULATION; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA, MESSENGER; S PHASE; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84860470892     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.147     Document Type: Article

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