The future: Therapy of myocardial protection

Annals of the New York Academy of Sciences

Volumn 1254, Issue 1, 2012, Pages 90-98

  Sanz Rosa, David ^a   García Prieto, Jaime ^a   Ibanez, Borja ^a,b  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

Author keywords

Infarct size; Ischemia reperfusion; Reperfusion injury; ST elevation myocardial infarction

Indexed keywords

ADENOSINE; ATRIAL NATRIURETIC FACTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; CYCLOSPORIN A; DELCASERTIB; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; NICORANDIL; NITRIC OXIDE; POTASSIUM ION; REACTIVE OXYGEN METABOLITE;

ACUTE HEART INFARCTION; ARTICLE; DISEASE DURATION; DRUG MEGADOSE; EMERGENCY HEALTH SERVICE; HEART DEATH; HEART FAILURE; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE REPERFUSION; HEART PROTECTION; HUMAN; ISCHEMIC POSTCONDITIONING; MITOCHONDRIAL PERMEABILITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERCUTANEOUS CORONARY INTERVENTION; REPERFUSION INJURY; SOCIAL WORK; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION;

ANIMALIA;

EID: 84860470610     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06501.x     Document Type: Article

References (62)

1. DeWood, M.A., J. Spores, R. Notske, et al 1980. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N. Engl. J. Med. 303: 897-902.
2. Jennings, R.B. & K.A. Reimer 1983. Factors involved in salvaging ischemic myocardium: effect of reperfusion of arterial blood. Circulation 68: I25-I36.
3. 1986. Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo italiano per lo studio della streptochinasi nell'infarto miocardico (gissi). Lancet 1: 397-402.
4. 1997. A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. The global use of strategies to open occluded coronary arteries in acute coronary syndromes (gusto iib) angioplasty substudy investigators. N. Engl. J. Med. 336: 1621-1628.
5. Braunwald, E. & R.A. Kloner 1985. Myocardial reperfusion: a double-edged sword? J. Clin. Invest. 76: 1713-1719.
6. Terkelsen, C.J., J.T. Sorensen, M. Maeng, et al 2010. System delay and mortality among patients with stemi treated with primary percutaneous coronary intervention. JAMA: J. Am. Med. Assoc. 304: 763-771.
7. Murry, C.E., R.B. Jennings & K.A. Reimer 1986. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124-1136.
8. Kloner, R.A., T. Shook, K. Przyklenk, et al 1995. Previous angina alters in-hospital outcome in timi 4. A clinical correlate to preconditioning? Circulation 91: 37-45.
9. Zhao, Z.Q., J.S. Corvera, M.E. Halkos, et al 2003. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am. J. Physiol. Heart Circ. Physiol. 285: H579-H588.
10. Hausenloy, D.J. & D.M. Yellon 2004. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury salvage kinase (risk)-pathway. Cardiovasc. Res. 61: 448-460.
11. Vinten-Johansen, J., D.M. Yellon & L.H. Opie 2005. Postconditioning: a simple, clinically applicable procedure to improve revascularization in acute myocardial infarction. Circulation 112: 2085-2088.
12. Staat, P., G. Rioufol, C. Piot, et al 2005. Postconditioning the human heart. Circulation 112: 2143-2148.
13. Freixa, X., N. Bellera, J.T. Ortiz-Perez, et al 2012. Ischaemic postconditioning revisited: lack of effects on infarct size following primary percutaneous coronary intervention. Eur. Heart J. 33: 103-112.
14. Botker, H.E., R. Kharbanda, M.R. Schmid, et al 2010. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 375: 727-734.
15. Schmidt, M.R., M. Smerup, I.E. Konstantinov, et al 2007. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a katp-dependent mechanism: first demonstration of remote ischemic perconditioning. Am. J. Physiol. Heart Circ. Physiol. 292: H1883-H1890.
16. Ross, A.M., R.J. Gibbons, G.W. Stone, R.A. Kloner & R.W. Alexander 2005. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (amistad-ii). J. Am. Coll. Cardiol. 45: 1775-1780.
17. Kloner, R.A., M.B. Forman, R.J. Gibbons, et al 2006. Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the amistad-2 trial. Eur. Heart J. 27: 2400-2405.
18. Desmet, W., J. Bogaert, C. Dubois, et al 2011. High-dose intracoronary adenosine for myocardial salvage in patients with acute st-segment elevation myocardial infarction. Eur. Heart J. 32: 867-877.
19. Hausenloy, D.J. & D.M. Yellon 2007. Preconditioning and postconditioning: united at reperfusion. Pharmacol. Ther. 116: 173-191.
20. Hausenloy, D.J. & D.M. Yellon 2003. The mitochondrial permeability transition pore: its fundamental role in mediating cell death during ischaemia and reperfusion. J. Mol. Cell Cardiol. 35: 339-341.
21. Javadov, S. & M. Karmazyn 2007. Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection. Cell Physiol. Biochem. 20: 1-22.
22. Piper, H.M., Y. Abdallah & C. Schafer 2004. The first minutes of reperfusion: a window of opportunity for cardioprotection. Cardiovasc. Res. 61: 365-371.
23. Griffiths, E.J. & A.P. Halestrap 1995. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem. J. 307(Pt 1): 93-98.
24. Oka, N., L. Wang, W. Mi, et al 2008. Cyclosporine a prevents apoptosis-related mitochondrial dysfunction after neonatal cardioplegic arrest. J. Thoracic Cardiovasc. Surg. 135: 123-130, 130 e121-122.
25. Ibanez, B. & J.J. Badimon 2008. Cyclosporine in acute myocardial infarction. N. Engl. J. Med. 359: 2287; author reply 2288-2289.
26. Piot, C., P. Croisille, P. Staat, et al 2008. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N. Engl. J. Med. 359: 473-481.
27. Kitakaze, M., M. Asakura, J. Kim, et al 2007. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (j-wind): two randomised trials. Lancet 370: 1483-1493.
28. Ibanez, B., V. Fuster, J. Jimenez-Borreguero & J.J. Badimon 2011. Lethal myocardial reperfusion injury: a necessary evil? Int. J. Cardiol. 151: 3-11.
29. Rodriguez-Sinovas, A., Y. Abdallah, H.M. Piper & D. Garcia-Dorado 2007. Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction. Heart Fail. Rev. 12: 207-216.
30. Klein, H.H., S. Pich, S. Lindert, et al 1989. Treatment of reperfusion injury with intracoronary calcium channel antagonists and reduced coronary free calcium concentration in regionally ischemic, reperfused porcine hearts. J. Am. Coll. Cardiol. 13: 1395-1401.
31. Gumina, R.J., E. Buerger, C. Eickmeier, et al 1999. Inhibition of the na(+)/h(+) exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. Circulation 100: 2519-2526; discussion 2469-2572.
32. Zeymer, U., H. Suryapranata, J.P. Monassier, et al 2001. The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (escami) trial. J. Am. Coll. Cardiol. 38: 1644-1650.
33. Ishii, H., S. Ichimiya, M. Kanashiro, et al 2005. Impact of a single intravenous administration of nicorandil before reperfusion in patients with st-segment-elevation myocardial infarction. Circulation 112: 1284-1288.
34. Frangogiannis, N.G., C.W. Smith, M.L. Entman 2002. The inflammatory response in myocardial infarction. Cardiovasc. Res. 53: 31-47.
35. Petzelbauer, P., P.A. Zacharowski, Y. Miyazaki, et al 2005. The fibrin-derived peptide beta15-42 protects the myocardium against ischemia-reperfusion injury. Nat. Med. 11: 298-304.
36. Atar, D., P. Petzelbauer, J. Schwitter, et al 2009. Effect of intravenous fx06 as an adjunct to primary percutaneous coronary intervention for acute st-segment elevation myocardial infarction results of the f.I.R.E. (efficacy of fx06 in the prevention of myocardial reperfusion injury) trial. J. Am. Coll. Cardiol. 53: 720-729.
37. Yellon, D.M. & D.J. Hausenloy 2007. Myocardial reperfusion injury. N. Engl. J. Med. 357: 1121-1135.
38. Opie, L.H. 2008. Metabolic management of acute myocardial infarction comes to the fore and extends beyond control of hyperglycemia. Circulation 117: 2172-2177.
39. Maroko, P.R., P. Libby, B.E. Sobel, et al 1972. Effect of glucose-insulin-potassium infusion on myocardial infarction following experimental coronary artery occlusion. Circulation 45: 1160-1175.
40. Opie, L.H., K. Bruyneel & P. Owen 1975. Effects of glucose, insulin and potassium infusion on tissue metabolic changes within first hour of myocardial infarction in the baboon. Circulation 52: 49-57.
41. Fath-Ordoubadi, F. & K.J. Beatt 1997. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials. Circulation 96: 1152-1156.
42. Diaz, R., A. Goyal, S.R. Mehta, et al 2007. Glucose-insulin-potassium therapy in patients with st-segment elevation myocardial infarction. JAMA 298: 2399-2405.
43. Apstein, C.S. & L.H. Opie 2005. A challenge to the metabolic approach to myocardial ischaemia. Eur. Heart J. 26: 956-959.
44. Nikolaidis, L.A., S. Mankad, G.G. Sokos, et al 2004. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 109: 962-965.
45. Lonborg, J., N. Vejlstrup, H. Kelbaek, et al 2011. Exenatide reduces reperfusion injury in patients with st-segment elevation myocardial infarction. Eur. Heart J. doi:
46. Freemantle, N., J. Cleland, P. Young, J. Mason & J. Harrison 1999. Beta blockade after myocardial infarction: systematic review and meta regression analysis. BMJ 318: 1730-1737.
47. Antman, E.M., M. Hand, P.W. Armstrong, et al 2008. 2007 focused update of the acc/aha 2004 guidelines for the management of patients with st-elevation myocardial infarction: a report of the american college of cardiology/american heart association task force on practice guidelines: developed in collaboration with the canadian cardiovascular society endorsed by the american academy of family physicians: 2007 writing group to review new evidence and update the acc/aha 2004 guidelines for the management of patients with st-elevation myocardial infarction, writing on behalf of the 2004 writing committee. Circulation 117: 296-329.
48. Lopez-Sendon, J., K. Swedberg, J. McMurray, et al 2004. Expert consensus document on beta-adrenergic receptor blockers. Eur. Heart J. 25: 1341-1362.
49. Sommers, H.M. & R.B. Jennings 1972. Ventricular fibrillation and myocardial necrosis after transient ischemia. Effect of treatment with oxygen, procainamide, reserpine, and propranolol. Arch. Intern. Med. 129: 780-789.
50. Ibanez, B., S. Prat-Gonzalez, W.S. Speidl, et al 2007. Early metoprolol administration before coronary reperfusion results in increased myocardial salvage: analysis of ischemic myocardium at risk using cardiac magnetic resonance. Circulation 115: 2909-2916.
51. Ibanez, B., G. Cimmino, S. Prat-Gonzalez, et al 2011. The cardioprotection granted by metoprolol is restricted to its administration prior to coronary reperfusion. Int. J. Cardiol. 147: 428-432.
52. Ibanez, B., V. Fuster, C. Macaya, et al 2011. [Modulation of the beta-adrenergic system during acute myocardial infarction: rationale for a new clinical trial]. Rev. Esp. Cardiol. 64(Suppl 2):28-33.
53. Sanz-Rosa, D., J. García-Prieto, A. Osuna, V. Fuster & B. Ibanez. 2011. β3 adrenergic receptor stimulation protects the heart from ischemia/reperfusion injury. Evolving challenges in promoting cardiovascular health (NYAS meeting, Barcelona).
54. Aragon, J.P., M.E. Condit, S. Bhushan, et al 2011. Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation. J. Am. Coll. Cardiol. 58: 2683-2691.
55. Suarez-Barrientos, A., P. Lopez-Romero, D. Vivas, et al 2011. Circadian variations of infarct size in acute myocardial infarction. Heart 97: 970-976.
56. Reiter, R., C. Swingen, L. Moore, T.D. Henry & J.H. Traverse 2012. Circadian dependence of infarct size and left ventricular function after st elevation myocardial infarction. Circ Res. 110: 105-110.
57. Arroyo Úcar, E., A. Dominguez-Rodriguez, P. Abreu-Gonzalez 2012. Influence of diurnal variation in the size of acute myocardial infarction. Med. Intensiva. 36: 11-14.
58. Bar, F.W., D. Tzivoni, M.T. Dirksen, et al. 2006. Results of the first clinical study of adjunctive CAldaret (MCC-135) in patients undergoing primary percutaneous coronary intervention for ST-Elevation Myocardial Infarction: the randomized multicentre CASTEMI study. Eur. Heart J. 27: 2516-2523.
59. Bates, E., C. Bode, M. Costa, et al. 2008. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation 117: 886-896.
60. Lonborg, J., H. Kelbaek, N. Vejlstrup, et al. 2010. Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Circ. Cardiovasc. Interv. 3: 34-41.
61. Fan, Q., X.C. Yang, Y. Liu, et al. 2011. Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans. Clin. Sci. (Lond.) 120: 251-261.
62. Garcia, S., T.D. Henry, Y.L. Wang, et al. 2011. Long-term follow-up of patients undergoing postconditioning during ST-elevation myocardial infarction. J. Cardiovasc. Transl. Res. 4: 92-98.