The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 10, 2012, Pages 3485-3487

  Song, Weibin ^a,b   Hu, Lingjun ^c   Meng, Yuhui ^a   Ma, Lei ^b   Guo, Dean ^a   Liu, Xuan ^a   Hu, Lihong ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Biomimetic coupling; C 16 substituent effects; Cytotoxicity; Structure activity relationship (SAR); Vinorelbine analogues

Indexed keywords

CATHARANTHINE; CYTOTOXIC AGENT; NAVELBINE; UNCLASSIFIED DRUG; VINDOLINE; VINORELBINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOMIMETIC COUPLING REACTION; BIOMIMETICS; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CYTOPATHOGENIC EFFECT; DRUG DESIGN; DRUG SYNTHESIS; ELECTRON TRANSPORT; HUMAN; HUMAN CELL; IC 50; REACTION ANALYSIS; REPRODUCIBILITY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOMIMETICS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP; VINBLASTINE;

EID: 84860453991     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.082     Document Type: Article

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