Spiroindolines identify the vesicular acetylcholine transporter as a novel target for insecticide action

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Sluder, Ann ^a,d   Shah, Sheetal ^b,e   Cassayre, Jérôme ^c   Clover, Ralph ^a   Maienfisch, Peter ^c   Molleyres, Louis Pierre ^c   Hirst, Elizabeth A ^b   Flemming, Anthony J ^b   Shi, Min ^b   Cutler, Penny ^b   Stanger, Carole ^b   Roberts, Richard S ^b,f   Hughes, David J ^b   Flury, Thomas ^c   Robinson, Michael P ^b   Hillesheim, Elke ^c   Pitterna, Thomas ^c   Cederbaum, Fredrik ^c   Worthington, Paul A ^b   Crossthwaite, Andrew J ^b   Windass, John D ^b   Currie, Richard A ^b   Earley, Fergus G P ^b   more..

^a Cambria Pharmaceuticals Inc   (United States)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^c SYNGENTA CROP PROTECTION AG   (Switzerland)

^d SCYNEXIS Inc   (United States)

^e SYNGENTA BIOTECHNOLOGY INC   (United States)

^f Laboratorios Almirall SA ^*  (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; INSECTICIDE; SYN 351; SYN 876; UNCLASSIFIED DRUG; VESICULAR ACETYLCHOLINE TRANSPORTER; ANTINEMATODAL AGENT; CAENORHABDITIS ELEGANS PROTEIN; FUSED HETEROCYCLIC RINGS; ISOPROTEIN; SPIRO COMPOUND; UNC 17 PROTEIN, C ELEGANS; UNC-17 PROTEIN, C ELEGANS;

AGRICULTURE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MOLECULAR GENETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CAENORHABDITIS ELEGANS; CELL CULTURE; CELL STRAIN; CHEMICAL STRUCTURE; CHEMISTRY; DROSOPHILA MELANOGASTER; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; INSECT; LARVA; METABOLISM; PROTEIN BINDING; RAT; SEQUENCE HOMOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALIA; HEXAPODA; MAMMALIA;

ACETYLCHOLINE; AMINO ACID SEQUENCE; ANIMALS; ANTINEMATODAL AGENTS; BIOLOGICAL TRANSPORT; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELLS, CULTURED; DROSOPHILA MELANOGASTER; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; INSECTICIDES; INSECTS; LARVA; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PC12 CELLS; PROTEIN BINDING; PROTEIN ISOFORMS; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SPIRO COMPOUNDS; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 84860451219     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034712     Document Type: Article

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