Analysis of Point Mutants in the Caenorhabditis elegans Vesicular Acetylcholine Transporter Reveals Domains Involved in Substrate Translocation

Journal of Biological Chemistry

Volumn 276, Issue 45, 2001, Pages 41580-41587

  Zhu, Heming ^a   Duerr, Janet S ^c   Varoqui, Hélène ^a,b   McManus, John R ^c   Rand, James B ^c   Erickson, Jeffrey D ^a,b  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; MUTAGENESIS; PROTEINS;

MUTANTS;

BIOCHEMISTRY;

ACETYLCHOLINE; ACETYLCHOLINE TRANSPORTER; CARRIER PROTEIN; UNCLASSIFIED DRUG; VESAMICOL; CHOLINERGIC RECEPTOR; PIPERIDINE DERIVATIVE;

ACETYLCHOLINE RELEASE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; GENE EXPRESSION; GENE STRUCTURE; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SITE DIRECTED MUTAGENESIS; SYNAPSE VESICLE; WILD TYPE; ANIMAL; CELL STRAIN; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA;

ACETYLCHOLINE; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CAENORHABDITIS ELEGANS; MOLECULAR SEQUENCE DATA; PC12 CELLS; PIPERIDINES; POINT MUTATION; RATS; RECEPTORS, CHOLINERGIC; SYNAPTIC VESICLES;

EID: 0346909527     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103550200     Document Type: Article

References (58)

1. Rand, J. B., and Russell, R. L. (1984) Genetics 106, 227-248
2. Rand, J. B. (1989) Genetics 122, 73-80
3. Alfonso, A., Grundahl, K., Duerr, J. S., Han, H.-P., and Rand, J. B. (1993) Science 261, 617-619
4. Alfonso, A., Grundahl, K., McManus, J. R., Asbury, J. M., and Rand, J. B. (1994) J. Mol. Biol. 241, 627-630
5. Hosono, R., Sassa, T., and Kuno, S. (1989) Zool. Sci. 6, 697-702
6. Nguyen, M., Alfonso, A., Johnson, C. D., and Rand, J. B. (1995) Genetics 140, 527-535
7. Kitamoto, R., Xie, X., Wu, C. F., and Salvaterra, P. M. (2000) J. Neurobiol. 42, 161-171
8. Song, H., Ming, G., Fon, E., Bellocchio, E., Edwards, R. H., and Poo, M. (1997) Neuron 18, 815-826
9. Varoqui, H., and Erickson, J. D. (1996) J. Biol. Chem. 271, 27229-27232
10. Liu, Y., and Edwards, R. H. (1997) J. Cell Biol. 139, 907-916
11. Varoqui, H., Diebler, M.-F., Meunier, F.-M., Rand, J. B., Usdin, T. B., Bonner, T. I., Eiden, L. E., and Erickson, J. D. (1994) FEBS Lett. 342, 97-102
12. Erickson, J. D., Varoqui, H., Schäfer, M. K.-H., Diebler, M.-F., Weihe, E., Modi, W., Rand, J. B., Eiden, L. E., Bonner, T. I., and Usdin, T. (1994) J. Biol. Chem. 269, 21929-21932
13. Brittain, R. T., Levy, G. P., and Tyers, M. B. (1969) Eur. J. Pharmacol. 8, 93-99
14. Marshall, I. G. (1970) Br. J. Pharmacol. 38, 503-516
15. Vizi, E. S. (1989) Br. J. Pharmacol. 98, 898-902
16. Kim, M.-H., Lu, M., Kelly, M., and Hersh, L. B. (2000) J. Biol. Chem. 275, 6175-6180
17. Kim, M.-H., Lu, M., Lim, E.-H., Chai, Y.-H., and Hersh, L. B. (1999) J. Biol. Chem. 274, 673-680
18. Eiden, L. E. (1998) J. Neurochem. 70, 2227-2240
19. Nguyen, M. L., Cox, G. D., and Parson, S. M. (1998) Biochemistry 37, 13400-13410
20. Varoqui, H., and Erickson, J. D. (1998) J. Physiol. (Paris) 92, 141-144
21. Merickel, A., Rosandich, P., Peter, D., and Edwards, R. H. (1995) J. Biol. Chem. 270, 25798-25804
22. Steiner-Mordoch, S., Shirvan, A., and Schuldiner, S. (1996) J. Biol. Chem. 271, 13048-13054
23. Merickel, A., Kaback, H. R., and Edwards, R. H. (1997) J. Biol. Chem. 272, 5403-5408
24. Lee, J. A., Püttner, I. B., and Kaback, H. R. (1989) Biochemistry 28, 2540-2544
25. He, M. M., and Kaback, H. R. (1997) Biochemistry 36, 13688-13692
26. Sahin-Toth, M., Karlin, A., and Kaback, H. R. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10729-10732
27. Parsons, S. M. (2000) FASEB J. 14, 2423-2434
28. Brenner, S. (1974) Genetics 77, 71-94
29. Miller, K. G., Alfonso, A., Nguyen, M., Crowell, J. A., Johnson, C. D., and Rand, J. B. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12593-12598
30. Rand, J. B., and Russell, R. L. (1985) Psychopharmacol. Bull. 21, 623-630
31. Williams, B. D., Schrank, B., Huynh, C., Shownkeen, R., and Waterston, R. H. (1992) Genetics 131, 609-624
32. Albertson, D. G. (1984) Dev. Biol. 101, 61-72
33. Duerr, J. S., Gaskin, J., and Rand, J. B. (2001) Am. J. Physiol. Cell Physiol. 280, C1616-C1622
34. Lickteig, K. M., Duerr, J. S., Frisby, D. L., Hall, D. H., Rand, J. B., and Miller, D. M., III. (2001) J. Neurosci. 21, 2001-2014
35. Duerr, J. S., Frisby, D. L., Gaskin, J., Duke, A., Asermely, K., Huddleston, D., Eiden, L. E., and Rand, J. B. (1999) J. Neurosci. 19, 72-84
36. Rand, J. B., and Johnson, C. D. (1995) in C. elegans: Modern Biological Analysis of an Organism (Epstein, H. F., and Shakes, D. C., eds), pp.187-204, Academic Press, San Diego
37. Deng, W. P., and Nickoloff, J. A. (1992) Anal. Biochem. 200, 81-85
38. Varoqui, H., and Erickson, J. D. (1998) J. Biol. Chem. 273, 9094-9098
39. Weihe, E., Tao-Chemg, J., Schäfer, M. K.-H., Erickson, J. D., and Eiden, L. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 3547-3552
40. Grote, E., Hao, J., Bennett, M. K., and Kelly, R. B. (1995) Cell 81, 581-589
41. Bradford, M. M. (1976) Anal. Biochem. 73, 248-254
42. Varoqui, H., and Erickson, J. D. (1998) in Methods in Enzymology: Neurotransmitter Transporters (Amara, S. G., ed), pp. 84-98, Academic Press, New York
43. Chen, X.-Z., Coady, M. J., Jackson, F., Berteloot, A., and Lapoint, J.-Y. (1995) Biophys. J. 69, 2405-2414
44. Wadiche, J. I., and Kavanaugh, M. P. (1998) J. Neurosci. 18, 7650-7661
45. Kanner, B. I., Fishkes, H., Maron, R., Sharon, I., and Schuldiner, S. (1979) FEBS Lett. 100, 175-178
46. Henry, J.-P., Gasnier, B., Roisin, M. P., Isambert, M.-F., and Scherman, D. (1987) Ann. N. Y. Acad. Sci. 493, 194-206
47. Darchen, F., Scherman, D., and Henry, J.-P. (1989) Biochemistry 28, 1692-1697
48. Henry, J.-P., and Scherman, D. (1989) Biochem. Pharmacol. 38, 2395-2404
49. Rudnick, G., Steiner-Mordoch, S. S., Fishkes, H., Stern-Bach, Y., and Schuldiner, S. (1990) Biochemistry 29, 603-608
50. Schuldiner, S., Liu, Y., and Edwards, R. H. (1993) J. Biol. Chem. 268, 29-34
51. Bahr, B. A., and Parsons, S. M. (1986) J. Neurochem. 46, 1214-1218
52. Diebler, M.-F., and Morot Gaudry-Talarmain, Y. (1989) J. Neurochem. 52, 813-821
53. Parsons, S. M., Prior, C., and Marshall, I. G. (1993) Int. Rev. Neurobiol. 35, 279-390
54. Varoqui, H., and Erickson, J. D. (1997) Mol. Neurobiol. 15, 165-191
55. Keller, J. E., Bravo, D. T., and Parsons, S. M. (2000) J. Neurochem. 74, 1739-1748
56. Pothos, E., Desmond, M., and Sulzer, D. (1996) J. Neurochem. 66, 629-636
57. Ulus, I. H., Wurtman, R. J., Mauron, C., and Blusztajn, J. K. (1989) Brain Res. 484, 217-227
58. Koshimura, K., Miwa, S., Lee, K., Hayashi, Y., Hasegawa, H., Hamahata, K., Fujiwara, M., Kimura, M., and Itokawa, Y. (1990) J. Neurochem. 54, 533-539