Enhanced analyte detection using in-source fragmentation of field asymmetric waveform ion mobility spectrometry-selected ions in combination with time-of-flight mass spectrometry

Analytical Chemistry

Volumn 84, Issue 9, 2012, Pages 4095-4103

  Brown, Lauren J ^a   Smith, Robert W ^a   Toutoungi, Danielle E ^b   Reynolds, James C ^a   Bristow, Anthony W T ^c   Ray, Andrew ^c   Sage, Ashley ^d   Wilson, Ian D ^c   Weston, Daniel J ^c   Boyle, Billy ^b   Creaser, Colin S ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b Owlstone Ltd   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

^d AGILENT TECHNOLOGIES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTE DETECTION; ASYMMETRIC WAVEFORMS; COLLISION-INDUCED DISSOCIATION; COMPLEX MIXTURE; DATABASE SEARCHING; HUMAN PLASMA PROTEINS; HUMAN PLASMAS; IN-SOURCE CID; ION MASS; ION MOBILITY; ION SELECTION; MASS DIFFERENCE; MASS MEASUREMENTS; MODEL PEPTIDES; PEPTIDE IDENTIFICATION; PHARMACEUTICAL EXCIPIENT; PRE-SELECTION; PRECURSOR IONS; QUALITATIVE AND QUANTITATIVE ANALYSIS; QUANTITATIVE DETERMINATIONS; REPRODUCIBILITIES; SOURCE REGION; TIME OF FLIGHT MASS SPECTROMETRY; TRYPTIC PEPTIDES; ULTRA-HIGH;

DISSOCIATION; ION SOURCES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDES; PLASMA (HUMAN); SEARCH ENGINES;

MASS SPECTROMETERS;

EXCIPIENT; ION; PEPTIDE;

ARTICLE; BLOOD; CHEMISTRY; EQUIPMENT DESIGN; EVALUATION; HUMAN; INSTRUMENTATION; MASS SPECTROMETRY; METHODOLOGY; SENSITIVITY AND SPECIFICITY;

EQUIPMENT DESIGN; EXCIPIENTS; HUMANS; IONS; MASS SPECTROMETRY; PEPTIDES; SENSITIVITY AND SPECIFICITY;

EID: 84860445338     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac300212r     Document Type: Article

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