The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder

World Journal of Biological Psychiatry

Volumn 13, Issue 4, 2012, Pages 306-311

  Pivac, Nela ^a   Kozaric Kovacic, Dragica ^b   Grubisic Ilic, Mirjana ^b   Nedic, Gordana ^a   Rakos, Iva ^b   Nikolac, Matea ^a   Blazev, Martina ^b   Muck Seler, Dorotea ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b University of Zagreb School of Medicine   (Croatia)

Author keywords

BDNF; Polymorphism; Psychosis; PTSD; Veterans

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METFORMIN; VALINE;

ADULT; ALLELE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTTRAUMATIC STRESS DISORDER; PSYCHOSIS; VETERAN;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; COMBAT DISORDERS; CROATIA; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PSYCHOTIC DISORDERS; STRESS DISORDERS, POST-TRAUMATIC; VETERANS;

EID: 84860434777     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2011.582883     Document Type: Article

References (23)

1. Braakman MH, Kortmann FAM, van den Brink W, Verkes RJ. 2008. Post-traumatic stress disorder with secondary psychotic features: neurobiological findings. Chapter 27. In: de Kloet ER, Oitzl MS, Vermetten E, editors. Stress hormones and post traumatic stress disorder: basic studies and clinical perspectives. Progress in Brain Research. Vol. 167. New York: Elsevier. p 299-302. (Pubitemid 350130353)
2. Braakman MH, Kortmann FAM, van den Brink W. 2009. Validity of post-traumatic stress disorder with secondary psychotic features: a review of the evidence. Acta Psychiatr Scand 119: 15-24.
3. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. 2003. The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112: 257-269. (Pubitemid 36144114)
4. Frielingsdorf H, Bath KG, Soliman F, DiFede JA, Casey BJ, Lee FS. 2010. Variant brain-derived neurotrophic factor Val-66Met endophenotypes: implications for posttraumatic stress disorder. Ann NY Acad Sci 1208: 150-157.
5. Gratacos M, Gonzalez JR, Mercader JM, de Cid R, Urretavizcaya M, Estivill X. 2007. Brain-derived neurotrophic factor Val-66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry 61: 911-922. (Pubitemid 46420580)
6. Hamner MB, Robert R, Frueh BC. 2004. Treatment-resistant posttraumatic stress disorder: strategies for intervention. CNS Spectrums 9: 740-752.
7. Kawashima K, Ikeda M, Kishi T, Kitajima T, Yamanouchi Y, Kinoshita Y, et al. 2009. BDNF is not associated with schizophrenia: Data from a Japanese population study and metaanalysis. Schizophrenia Res 112: 72-79.
8. Kozaric-Kovacic D, Borovecki A. 2005. Prevalence of psychotic comorbidity in combat related PTSD. Mil Med 170: 223-226. (Pubitemid 40731884)
9. Kozaric-Kovacic D, Pivac N. 2007. Quetiapine treatment in an open trial in combat-related post-traumatic stress disorder with psychotic features. Int J Neuropsychopharmacol 10: 253-261.
10. Kozaric-Kovacic D, Pivac N, Muck-Seler D, Rothbaum BO. 2005. Risperidone in psychotic combat-related posttraumatic stress disorder: an open trial. J Clin Psychiatry 66: 922-927. (Pubitemid 41032835)
11. Lee HJ, Kang RH, Lim SW, Paik JW, Choi MJ, Lee MS. 2006. No association between the brain-derived neurotrophic factor gene Val66Met and posttraumatic stress disorder. Stress Health 22: 115-119.
12. Miller SA, Dykes D, Polesky HF. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acid Res 16: 1215.
13. Pivac N, Kozaric-Kovacic D, Muck-Seler D. 2004. Olanzapine versus fl uphenazine in an open trial in patients with psychotic combat-related post-traumatic stress disorder. Psychopharmacology 175: 451-456. (Pubitemid 39362043)
14. Pivac N, Kozaric-Kovacic D, Mustapic M, Dezeljin D, Borovecki A, Grubisic-Ilic M, et al. 2006. Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms. J Affect Disord 93: 223-227. (Pubitemid 43816057)
15. Pivac N, Knezevic J, Kozaric-Kovacic D, Dezeljin M, Mustapic M, Rak D, et al. 2007. Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat related posttraumatic stress disorder. J Affect Disord 103: 131-138. (Pubitemid 47445764)
16. Pivac N, Kim B, Nedic G, Joo YH, Kozaric-Kovacic D, Hong JP, et al. 2009. Ethnic differences in the brain-derived neurotrophic factor Val66Met polymorphism in Croatian and Korean healthy subjects. Croat Med J 50: 43-48.
17. Pivac N, Nikolac M, Nedic G, Mustapic M, Borovecki F, Hajnsek S, et al. 2011. Brain derived neurotrophic factor Val66Met polymorphism and psychotic symptoms in Alzheimer ' s disease. Progr Neuro-Psychopharmacol Biol Psychiatry 35: 356-362.
18. Pregelj P, Nedic G, Videtic Paska A, Zupanc T, Nikolac M, Balazic J, et al. 2011. The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. J Affect Disord 128: 287-290.
19. Russo-Neustadt A. 2003. Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders. Semin Clin Neuropsychiatry 8: 109-118. (Pubitemid 36828242)
20. Sautter FJ, Bissette G, Wiley J, Manguno-Mire G, Schoenbachler B, Myers L, et al. 2003. Corticotrophin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects. Biol Psychiatry 54: 1382-1388. (Pubitemid 37522162)
21. Shevlin M, Armour C, Murphy J, Houston JE, Adamson G. 2010. Evidence for a psychotic posttraumatic stress disorder subtype based on the National Comorbidity Survey. Soc Psychiatr Psychiatr Epidemiol (doi: 10.1007/s00127-010- 0281-4).
22. Verhagen M, van der Meij A, van Deurzen PAM, Janzing JGE, Arias-Vásquez A, Buitelaar JK, et al. 2010. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 15: 260-271.
23. Zhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, et al. 2006. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. Am J Med Genet B Neuropsychiatr Genet 141B: 387-393. (Pubitemid 43872891)