TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma

Journal of Hepatology

Volumn 55, Issue 3, 2011, Pages 721-723

  Greten, Florian R ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; I KAPPA B KINASE ALPHA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SUBUNIT; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR;

APOPTOSIS; BILIARY TRACT DISEASE; CATALYSIS; CELL DEATH; CELL PROLIFERATION; CHOLESTASIS; DYSPLASIA; ENZYME ACTIVATION; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER NECROSIS; LIVER PARENCHYMA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 84860421515     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.02.037     Document Type: Note

References (13)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer Statistics, 2009. CA: a cancer journal for clinicians 2009.
2. S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
3. M. Karin, and F.R. Greten NF-kappaB: linking inflammation and immunity to cancer development and progression Nat Rev Immunol 5 2005 749 759 (Pubitemid 41400849)
4. J. Bollrath, and F.R. Greten IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis EMBO Rep 10 2009 1314 1319
5. B. Sun, and M. Karin NF-kappaB signaling, liver disease and hepatoprotective agents Oncogene 27 2008 6228 6244
6. S. Maeda, H. Kamata, J.L. Luo, H. Leffert, and M. Karin IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis Cell 121 2005 977 990 (Pubitemid 40884391)
7. T. Luedde, N. Beraza, V. Kotsikoris, G. van Loo, A. Nenci, and R. De Vos Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma Cancer cell 11 2007 119 132 (Pubitemid 46209851)
8. H. Kamata, S. Honda, S. Maeda, L. Chang, H. Hirata, and M. Karin Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases Cell 120 2005 649 661 (Pubitemid 40343077)
9. T. Sakurai, S. Maeda, L. Chang, and M. Karin Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation Proc Natl Acad Sci USA 103 2006 10544 10551 (Pubitemid 44078014)
10. M. Rincon, and R.J. Davis Regulation of the immune response by stress-activated protein kinases Immunol Rev 228 2009 212 224
11. K. Bettermann, M. Vucur, J. Haybaeck, C. Koppe, J. Janssen, and F. Heymann TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer Cancer cell 17 2006 481 496
12. S. Inokuchi, T. Aoyama, K. Miura, C.H. Osterreicher, Y. Kodama, and K. Miyai Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis Proc Natl Acad Sci USA 107 2010 844 849
13. T. Sakurai, G. He, A. Matsuzawa, G.Y. Yu, S. Maeda, and G. Hardiman Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis Cancer cell 14 2008 156 165