Co-overexpression of the HMGR and FPS genes enhances artemisinin content in Artemisia annua L

Journal of Medicinal Plants Research

Volumn 5, Issue 15, 2011, Pages 3396-3403

  Wang, Yueyue ^a   Jing, Fuyuan ^a   Yu, Shuoye ^a   Chen, Yunfei ^a   Wang, Tao ^a   Liu, Pin ^a   Wang, Guofeng ^a   Sun, Xiaofen ^a   Tang, Kexuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Artemisia annua L. (asteraceae); Artemisinin; Genetic engineering; hmgr and fps genes

Indexed keywords

ARTEMISININ;

ARTEMISIA ANNUA; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; EXPRESSION VECTOR; FARNESYL DIPHOSPHATE SYNTHASE GENE; FLUORESCENCE ANALYSIS; GENE INSERTION; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE GENE; LIGHT SCATTERING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; REGULATOR GENE; SOUTHERN BLOTTING; TRANSGENIC PLANT;

AGROBACTERIUM; ARTEMISIA ANNUA; ASTERACEAE; CAULIFLOWER MOSAIC VIRUS;

EID: 84860419914     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Bertea CM, Freije JR, Vander WH, Verstappen FWA, Perk L, Marquez V, De KJW, Posthumus MA, Jansen BJM, Ae. DG, Franssen MCR, Bouwmeester HJ (2005). Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. Planta. Med., 71: 40-47.
2. Chappell J, Wolf F, Proulx J, Cuellar R, Saunders C (1995). Is the reaction catalyzed by 3-hydroxyl-3-methylglutaryl coenzyme A reductase a rate-limiting step for isorenoid biosynthesis in plants. Plant Physiol., 109: 1337-1343.
3. Chappell J (1995). Biochemistry and molecular biology of the isoprenoid biosynthetic pathway in plants. Ann. Rev. Plant Physiol. Plant Mol Biol., 46: 521-547.
4. Chen DH, Meng Y, Ye HC, Liu BY (1998). Cultures of transgenic artemisia annua hairy root with cotton cadinene systhase gene. Acta Bot. Sin., 40: 711-714.
5. Cunillera N, Arró M, Delourme D, Karst F, Boronat A, Ferrer A (1996). Arabidopsis thaliana Contains Two Differentially Expressed Farnesyl- Diphosphate Synthase Genes. J. Biol. Chem., 27(13): 7774-7780.
6. Klayman DL (1985). Qinghaosu (artemisinin): an antimalarial drug from China. Sci., 228: 1049-1055.
7. Duke SO, Paul RN (1993). Development and fine structure of the glandular trichomes of Artemisia annua L. Int. J. Plant Sci., 154(1): 107-118.
8. Enjuto M, Balcells L, Campos N, Caelles C, Arró M, Boronat A (1993). Arabidopsis thaliana contains two differentially expressed 3-hydroxy- 3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme. Proc. Nat. Acad. Sci., USA. 91: 927-931.
9. Fulzele DP, Heble MR, Rao PS (1995). Production of terpenoid from Artemisia annua L. Plantlet cultures in bioreactor. J. Biotechnol., 40(2): 139-143.
10. Guo C, Liu CZ, Ye HC, Liu BY (2004). Effect of temperature on growth and artemisinin biosynthesis in hairy root cultures of Artemisia annua. Acta Bot. Sin., 24: 1828-1831.
11. He XC, Zeng MY, Li GF (1983). Callus inducton and regeneration of plantlets from Artemisia annua and changes in qinghaosu contents. Acta Bot. Sin., 25: 87-90.
12. Jung M, ElSohly HN, McChesney JD (1990). Artemisinic acid: a versatile Chiralsynthon and bioprecursor to natural products. Planta Med., 56: 624.
13. Kumar VR, Narasu ML, Kishor PBK (1997). Factors affecting in vitro production of artemisinin. Plant Tissue culture and biotechnology: emerging trends. Proceedings of a symposium held at Hyderabad. India, 29-31: 249-260.
14. Lai H, Singh NP (2006). Oral artemisinin prevents and delays the development of 7, 12-dimethylbenz[a] anthracene (DMBA)-induced breast cancer in the rat. Cancer Lett., 231(1): 43-48.
15. Leivar P, Gonzaez VM, Castel S, Trelease RN, López IC, Arró M, Boronat A, Campos N, Ferrer A, Fernàndez BX (2005). Subcellular Localization of Arabidopsis 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase. Plant Physiol., 137: 57-69.
16. Liao P, Zhou W, Zhang L, Wang J, Yan XM, Zhang Y, Zhang R, Li L, Zhou GY, Kai GY (2009). Molecular cloning, characterization and expression analysis of a new gene encoding 3-hydroxy-3- methylglutaryl coenzyme A reductase from Salvia miltiorrhiza. Acta Physiol. Plant, 31(3): 565-572.
17. Liu CZ, Guo C, Wang YC, Ouyang F (2002). Effect of light irradiation on hairy root growth and artemisinin biosynthesis of Artemisia annua L. Proc. Biochem., 38: 581-585.
18. Liu Y, Wang H, Ye HC, Liu BY (2005). Advances in the plant isoprenoid biosynthesis pathway and its metabolic engineering. J. Integr. Plant Biol., 47: 769-782.
19. Liu CZ, Zhao Y, Wang YC (2006). Appl. Microbiol. Biotechnol., 71: 11-20.
20. Lumbreras V, Campos N, Boronat A (1995). The use of an alternative promoter in the Arabidopsis thaliana HMG1 gene generates an mRNA that encodes a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase isoform with an extended N-terminal region. Plant J., 8(4): 541-549.
21. Martinez BC, Staba J (1988). The production of artemisinin in Artemisia annua L. tissue cultures. Adv. Cell Cult., 6: 69-87.
22. Murashige T, Skoog F (1962). A revised medium for rapid growth and bioassays with tobacco cultures. Plant Physiol., 15: 473-497.
23. Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B (2004). Anticancer and Antimalarial Efficacy and Safety of Artemisinin-Derived Trioxane Dimers in Rodents. J. Med. Chem., 47: 1299-1301.
24. Qian ZH, Gong K, Zhang L, Lv J, Jing F, Wang Y, Guan S, Wang G, Tang K (2007). A simple and efficient procedure to enhance artemisinin content in Artemisia annua L. by seeding to salinity stress. Afr. J. Biotechnol., 6 (12): 1410-1413.
25. Simon JE, Charles D, Cebert E, Grant L, Janick J, Whipkey A (1990). Artemisia annua L.: a promising aromatic and medicinal: Advances in new crops West Lafayette. Timber Press, Portland.
26. Smith TC, Weathers PS, Cheetan RD (1997). Effect of gibberillic acid on hairy root cultures of Artemisia annua growth and artemisinin production. In vitro Cell Dev. Biol. Plant, 33: 75-79.
27. Singh NP, Lai H (2001). Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells. Life Sci., 70(1): 49-56.
28. Vergauwe A, Cammaert R, Vandenberghe D, Genetello C, Inze D, Montagu M, Eeckhout E (1996). Agrobacterium tumefaciensmediated transformation of Artemisia annua L. and regeneration of transgenic plants. Plant Cell Rep., 15: 929-933.
29. Wang JX, Tang W, Shi LP, Wan J, Zhou R, Ni J, Fu YF, Yang YF, Li Y, Zuo JP (2007). Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation. Br. J. Pharmacol., 150(5): 652-661.
30. Wang YC, Zhang HX, Zhao B, Yuan XF (2001). Improved growth of Artemisia annua L. hairy roots and artemisinin production under red light conditions. Biotechnol. Lett., 23: 1971-1973.
31. Weathers PJ, Bunk G, Mccoy MC (2005). The effect of phytohormones on growth and artemisinin production in Artemisia annua hairy roots. In vitro Cell Dev. Biol. Plant, 41: 47-53.
32. Weissenborn DL, Denbow CJ, Laine M, Lång SS, Yang Z, Yu X, Cramer CL (1995). HMG-GoA reductase and terpenoid phytoalexins: Molecular specialization within a complex pathway. Physiol. Plant, 93(2): 393-400.
33. Whipkey A, Simon JE, Charles DJ, Janick J (1992). In vitro production of artemisinin from Artemisia annua L. Phytother. Res., 1: 15-25.
34. WHO (2006). Guidelines for the treatment of malaria.
35. Woerdenbag HJ, Luers JFJ, Uden W, Pras N, Malingré TM, Alfermann AW (1993). Productionof the new antimalarial drug in shoot cultures of Artemisia annua L. Plant Cell Tiss. Org. Cult., 32: 247-250.
36. Zhang L, Yan XM, Wang J, Li SS, Liao P, Kai GY (2010). Molecular cloning and expression analysis of a new putative gene encoding 3- hydroxy-3-methylglutaryl-CoA synthase from Salvia miltiorrhiza. Acta Physiol. Plant, DOI: 10.1007/s11738-010-0627-2.