Ezetimibe alone or in combination with pitavastatin prevents kidney dysfunction in 5/6 nephrectomized rats fed high-cholesterol

Metabolism: Clinical and Experimental

Volumn 61, Issue 3, 2012, Pages 379-388

  Mori, Yusaku ^a   Hirano, Tsutomu ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CAMPESTEROL; CHOLESTANOL; CONNECTIVE TISSUE GROWTH FACTOR; CREATININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EZETIMIBE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; NITRIC OXIDE; PITAVASTATIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DOWN REGULATION; DRUG EFFECT; ENZYME SYNTHESIS; FIBROSING ALVEOLITIS; FOOD INTAKE; GLOMERULOSCLEROSIS; HEART RATE; HYPERCHOLESTEROLEMIA; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; KIDNEY INJURY; LIPID BLOOD LEVEL; MACROPHAGE; MALE; NEPHRECTOMY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; RAT; RENAL PROTECTION; TREATMENT DURATION; UPREGULATION; URINARY EXCRETION; URINE LEVEL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; AZETIDINES; CHOLESTEROL; CHOLESTEROL, DIETARY; CHOLESTEROL, HDL; CREATININE; DEOXYGUANOSINE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; MALE; NEPHRECTOMY; PROTEINURIA; QUINOLINES; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RNA; TRIGLYCERIDES;

EID: 84860405952     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.07.004     Document Type: Article

References (49)

1. W.F. Keane Lipids and progressive renal failure Wien Klin Wochenschr 108 1996 420 424 (Pubitemid 26253643)
2. P. Muntner, J. Coresh, and J.C. Smith Plasma lipids and risk of developing renal dysfunction: the Atherosclerosis Risk in Communities study Kidney Int 58 2000 293 301 (Pubitemid 30429874)
3. S. Sandhu, N. Wiebe, and L.F. Fried Statins for improving renal outcomes: a meta-analysis J Am Soc Nephrol 17 2006 2006 2016 (Pubitemid 44036185)
4. K. Douglas, P.G. O'Malley, and J.L. Jackson Meta-analysis: the effect of statins on albuminuria Ann Intern Med 145 2006 117 124 (Pubitemid 46780585)
5. J. Shepherd, J.J. Kastelein, and V. Bittner Treating to New Targets Investigators. Effect of intensive lipid lowering with atorvastatin on renal function in patients with coronary heart disease: the Treating to New Targets (TNT) study Clin J Am Soc Nephrol 2 2007 1131 1139
6. A. Hartner, B. Klanke, and N. Cordasic Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate- salt hypertension J Hypertens 27 2009 376 385
7. W. Zhang, Q. Li, and L. Wang Simvastatin ameliorates glomerulosclerosis in Adriamycin-induced-nephropathy rats Pediatr Nephrol 23 2008 2185 2194
8. Y. Song, C. Li, and L. Cai Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation Exp Mol Pathol 76 2004 66 75 (Pubitemid 38096321)
9. S. Shibata, M. Nagase, and T. Fujita Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling J Am Soc Nephrol 17 2006 754 764
10. A. Endo, Y. Tsujita, and M. Kuroda Effects of ML-236B on cholesterol metabolism in mice and rats: lack of hypocholesterolemic activity in normal animals Biochim Biophys Acta 575 1979 266 276 (Pubitemid 10196661)
11. T. Hirano, F. Komuro, and S. Furukawa Effect of pravastatin sodium, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on very-low-density lipoprotein composition and kinetics in hyperlipidemia associated with experimental nephrosis Metabolism 39 1990 605 609 (Pubitemid 20184530)
12. W.F. Keane, W.S. Mulcahy, and B.L. Kasiske Hyperlipidemia and progressive renal disease Kidney Int Suppl 31 1991 S41 S48
13. M. Hattori, Y. Yamaguchi, and H. Kawaguchi Characteristic glomerular lesions in the ExHC rat: a unique model for lipid-induced glomerular injury Nephron 63 1993 314 322 (Pubitemid 23082074)
14. M. Garcia-Calvo, J. Lisnock, and H.G. Bull The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1) Proc Natl Acad Sci USA 102 2005 8132 8137 (Pubitemid 40800055)
15. T. Sudhop, D. Lütjohann, and K. von Bergmann Sterol transporters: targets of natural sterols and new lipid lowering drugs Pharmacol Ther 105 2005 333 341 (Pubitemid 40292725)
16. S.W. Altmann, H.R. Davis Jr, and L.J. Zhu Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption Science 303 2004 1201 1204 (Pubitemid 38233587)
17. N.D. Vaziri, Y. Bai, and Z. Ni Intra-renal angiotensin II/AT1 receptor, oxidative stress, inflammation, and progressive injury in renal mass reduction J Pharmacol Exp Ther 323 2007 85 93 (Pubitemid 47443257)
18. Y. Quiroz, A. Ferrebuz, and F. Romero Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction Am J Physiol Renal Physiol 294 2008 336 344
19. B. Zhang, X. Liang, and W. Shi Role of impaired peritubular capillary and hypoxia in progressive interstitial fibrosis after 5/6 subtotal nephrectomy of rats Nephrology 10 2005 351 357 (Pubitemid 41725510)
20. L.S. Santos, E.W. Chin, and S.O. Ioshii Surgical reduction of the renal mass in rats: morphologic and functional analysis on the remnant kidney Acta Cir Bras 21 2006 252 257 (Pubitemid 44198488)
21. J.M. Kaufman, N.J. Siegel, and J.P. Hayslett Functional and hemodynamic adaptation to progressive renal ablation Circ Res 36 1975 286 293
22. P. Gershkovich, J. Darlington, and O. Sivak Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds J Pharm Sci 98 2009 2390 2400
23. L. Jakulj, M.N. Vissers, and C.P. van Roomen Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice FEBS Lett 584 2010 3625 3628
24. N. Kobayashi, H. Takeshima, and H. Fukushima Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts Am J Hypertens 22 2009 176 182
25. I. Chinen, M. Shimabukuro, and K. Yamakawa Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats Endocrinology 148 2007 160 165 (Pubitemid 46021448)
26. T. Someya, K. Kaneko, and T. Yamada Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats Pediatr Nephrol 20 2005 1430 1434 (Pubitemid 41403418)
27. C. Iacobini, S. Menini, and G. Oddi Galectin-3/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury: evidence for a protective role of galectin-3 as an AGE receptor FASEB J 18 2004 1773 1775 (Pubitemid 39561680)
28. S.L. Garber, Y. Mirochnik, and S.S. Desai Angiotensin-converting enzyme inhibition reduces the effect of bromoethylamine-induced papillary necrosis and renal fibrosis J Am Soc Nephrol 9 1998 1052 1059 (Pubitemid 28264732)
29. M. Hino, M. Nagase, and S. Kaname Expression and regulation of adrenomedullin in renal glomerular podocytes Biochem Biophys Res Commun 330 2005 178 185 (Pubitemid 40394950)
30. Y. Ben-Shahar, A. Robichon, and M.B. Sokolowski Influence of gene action across different time scales on behavior Science 296 2002 741 744 (Pubitemid 34442003)
31. J.R. Diamond Analogous pathobiologic mechanisms in glomerulosclerosis and atherosclerosis Kidney Int 31 1991 29 34
32. S.D. Ricardo, H. van Goor, and J.R. Diamond Hypercholesterolemia and progressive kidney disease: the role of macrophages and macrophage-derived products Contrib Nephrol 120 1997 197 209
33. H.C. Rayner, L. Ward, and J. Walls Cholesterol feeding following unilateral nephrectomy in the rat leads to glomerular hypertrophy Nephron 57 1991 453 459
34. T. Nakamura, E. Sato, and N. Fujiwara Ezetimibe decreases serum levels of asymmetric dimethylarginine (ADMA) and ameliorates renal injury in non-diabetic chronic kidney disease patients in a cholesterol-independent manner Pharmacol Res 60 2009 525 528
35. Y. Liu, L.M. Hultén, and O. Wiklund Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production Arterioscler Thromb Vasc Biol 17 1997 317 323 (Pubitemid 27098190)
36. B.L. Kasiske, M.P. O'Donnell, and W.J. Garvis Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 5/6 nephrectomy model of chronic renal failure Circ Res 62 1988 367 374 (Pubitemid 18041958)
37. M. Eto, M. Saito, and M. Okada Apolipoprotein E genetic polymorphism, remnant lipoproteins, and nephropathy in type 2 diabetic patients Am J Kidney Dis 40 2002 243 251 (Pubitemid 34827641)
38. T. Nozue, I. Michishita, and I. Mizuguchi Effects of ezetimibe on remnant-like particle cholesterol, lipoprotein (a), and oxidized low-density lipoprotein in patients with dyslipidemia JÂ Atheroscler Thromb 17 2010 37 44
39. T. Hiro, T. Kimura, T. Morimoto JAPAN-ACS Investigators Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome: a multicenter randomized trial evaluated by volumetric intravascular ultrasound using pitavastatin versus atorvastatin (JAPAN-ACS (Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome) study) J Am Coll Cardiol 54 2009 293 302
40. I. Migdalis, A. Efthimiadis, and S. Pappas Clinical experience with EZE/simvastatin in a Mediterranean population Curr Med Res Opin 25 2009 2571 2576
41. J.G. Robinson, C.M. Ballantyne, and S.M. Grundy Lipid-altering efficacy and safety of ezetimibe/simvastatin versus atorvastatin in patients with hypercholesterolemia and the metabolic syndrome (from the VYMET study) Am J Cardiol 103 2009 1694 1702
42. T. Nakamura, E. Sato, and N. Fujiwara Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner Pharmacol Res 61 2010 58 61
43. S. Jelic, D.J. Lederer, and T. Adams Vascular inflammation in obesity and sleep apnea Circulation 121 2010 1014 1021
44. J.F. Arnal, A.T. Dinh-Xuan, and M. Pueyo Endothelium-derived nitric oxide and vascular physiology and pathology Cell Mol Life Sci 55 1999 1078 1087 (Pubitemid 29361074)
45. H.S. Lee, and C.Y. Song Differential role of mesangial cells and podocytes in TGF-beta-induced mesangial matrix synthesis in chronic glomerular disease Histol Histopathol 24 2009 901 908
46. I.Z. Pawluczyk, and K.P. Harris Cholesterol feeding activates macrophages to upregulate rat mesangial cell fibronectin production Nephrol Dial Transplant 15 2000 161 166 (Pubitemid 30064268)
47. K. Tamaki, and S. Okuda Role of TGF-beta in the progression of renal fibrosis Contrib Nephrol 139 2003 44 65
48. C. Baigent, M.J. Landray, and C. Reith The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial Lancet 377 2011 2181 2192
49. P.L. Drury, R. Ting, D. Zannino, C. Ehnholm, J. Flack, and M. Whiting Estimated glomerular filtration rate and albuminuria are independent predictors of cardiovascular events and death in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study Diabetologia. 54 2011 32 43