A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis

FEBS Journal

Volumn 278, Issue 17, 2011, Pages 3140-3151

  Bailey, Jaclyn ^a   Powell, Lakeila ^b   Sinanan, Leander ^c   Neal, Jacob ^c   Li, Ming ^d   Smith, Thomas ^d   Bell, Ellis ^c  

^a GUSTAVUS ADOLPHUS COLLEGE   (United States)

^b VIRGINIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF RICHMOND   (United States)

^d DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

Author keywords

allostery; glutamate dehydrogenase; protein dynamics; subunit interactions; zinc inhibition

Indexed keywords

AMINO ACID; EUROPIUM; GLUTAMATE DEHYDROGENASE; GUANOSINE TRIPHOSPHATE; NORVALINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ZINC;

ARTICLE; BINDING SITE; CATALYSIS; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STABILITY; ENZYME SUBUNIT; PRIORITY JOURNAL; PROTEIN INTERACTION; STEADY STATE; STRUCTURE ANALYSIS;

ANIMALS; BIOCATALYSIS; CALORIMETRY, DIFFERENTIAL SCANNING; CATALYTIC DOMAIN; CATTLE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ENZYME STABILITY; EUROPIUM; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; KINETICS; LIVER; MODELS, MOLECULAR; NADP; PROTEIN CONFORMATION; PROTEIN SUBUNITS; VALINE; ZINC; ZINC ACETATE;

BOVINAE;

EID: 84860391265     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08240.x     Document Type: Article

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