Carboxylate and aromatic active-site residues are determinants of high-affinity binding of ω-aminoaldehydes to plant aminoaldehyde dehydrogenases

FEBS Journal

Volumn 278, Issue 17, 2011, Pages 3130-3139

  Kopečný, David ^a   Tylichová, Martina ^a   Snegaroff, Jacques ^b   Popelková, Hana ^c   Šebela, Marek ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b INSTITUT JEAN PIERRE BOURGIN   (France)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

3 aminopropionaldehyde; 4 aminobutyraldehyde; 4 guanidinobutyraldehyde; aminoaldehyde dehydrogenase; betaine aldehyde

Indexed keywords

ALDEHYDE DEHYDROGENASE; AMINO ACID; AMINOALDEHYDE; AMINOALDEHYDE DEHYDROGENASE 2; AROMATIC AMINO ACID; BETAINE ALDEHYDE DEHYDROGENASE; CARBOXYLIC ACID; ISOPROTEIN; OMEGA AMINOALDEHYDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN INTERACTION; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

ALDEHYDE OXIDOREDUCTASES; ALDEHYDES; AMINO ACIDS, AROMATIC; AMINO ACIDS, DICARBOXYLIC; BETAINE; BIOCATALYSIS; CATALYTIC DOMAIN; CIRCULAR DICHROISM; ISOENZYMES; KINETICS; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PEAS; PLANT PROTEINS; PROPYLAMINES; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

PISUM SATIVUM;

EID: 84860390225     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08239.x     Document Type: Article

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