Cutaneous clear cell neoplasms: A histopathological reappraisal

American Journal of Dermatopathology

Volumn 34, Issue 3, 2012, Pages 237-254

  Biswas, Asok ^a   Mahalingam, Meera ^b  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

clear cell change; Clear cell tumors of the skin; differential diagnosis; skin neoplasms

Indexed keywords

ACANTHOMA; BASAL CELL CARCINOMA; CANCER PROGNOSIS; DYSKERATOSIS; ECCRINE POROCARCINOMA; ECCRINE POROMA; EPIDERMIS HYPERPLASIA; EPITHELIOID CELL; EXOCYTOSIS; FIBROXANTHOMA; HIDRADENOMA; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; JUVENILE MELANOMA; KERATINOCYTE; MELANOMA; MICROSCOPY; NEUROFIBROMA; PAPULOSIS; PRIORITY JOURNAL; REVIEW; SEBORRHEIC KERATOSIS; SKIN CARCINOMA; SKIN FIBROSIS; SKIN METASTASIS; SMALL CELL SARCOMA; SPINDLE CELL; TRICHOBLASTOMA; TUMOR CELL; TUMOR DIFFERENTIATION; XANTHOMA;

ADENOCARCINOMA, CLEAR CELL; CYTOPLASM; DIAGNOSIS, DIFFERENTIAL; HUMANS; MELANOMA; NEOPLASMS, ADNEXAL AND SKIN APPENDAGE; NEOPLASMS, FIBROUS TISSUE; SARCOMA; SKIN; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84860382770     PISSN: 01931091     EISSN: 15330311     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3182106d28     Document Type: Review

References (146)

1. Mehregan AH. Clear epidermal cells: an artifact. J Cutan Pathol. 1980;7: 154-157.
2. Civatte J. Clear-cell tumors of the skin: a histopathologic review. J Cutan Pathol. 1984;11:165-175. (Pubitemid 14088912)
3. Mehregan AH, Pinkus H. Artifacts in dermal histopathology. Arch Dermatol. 1966;94:218-225.
4. Toker C. Clear cells of the nipple epidermis. Cancer. 1970;25:601-610.
5. Willman JH, Golitz LE, Fitzpatrick JE. Vulvar clear cells of Toker. Precursors of extramammary Paget's disease. Am J Dermatopathol. 2005;27:185-188. (Pubitemid 40726769)
6. Marucci G, Betts CM, Golouh R, et al. Toker cells are probably precursors of Paget cell carcinoma: a morphological and ultrastructural description. Virchows Arch. 2002;441:117-123. (Pubitemid 34983977)
7. Van Der Putte SCJ, Toonstra J, Hennipman A. Mammary Paget's disease confined to the areola and associated with multifocal Toker cell hyperplasia. Am J Dermatopathol. 1995;17:487-493.
8. Garijo MF, Val D, Val-Bernal JF. Pagetoid dyskeratosis of the nipple epidermis: an incidental finding mimicking Paget's disease of the nipple. APMIS. 2008;116:139-146. (Pubitemid 351347593)
9. Val-Bernal JF, Garijo MF. Pagetoid dyskeratosis of the prepuce. An incidental histologic finding resembling extramammary Paget's disease. J Cutan Pathol. 2000;27:387-391. (Pubitemid 30487993)
10. Tschen JA, McGavran MH, Kettler AH. Pagetoid dyskeratosis: a selective keratinocytic response. J Am Acad Dermatol. 1988;19: 891-894. (Pubitemid 18261000)
11. Kohler S, Rouse RV, Smoller BR. The differential diagnosis of pagetoid cells in the epidermis. Mod Pathol. 1998;11:79-82.
12. Kuo TT, Chan HL, Hsueh S. Clear cell papulosis of the skin. A new entity with histogenetic implications for cutaneous Paget's disease. Am J Surg Pathol. 1987;11:827-834. (Pubitemid 18003392)
13. Lee JY-Y, Chao S-C. Clear cell papulosis of the skin. Br J Dermatol. 1998;138:678-683. (Pubitemid 28212258)
14. Kim YC, Mehregan DA, Dongsik B. Clear cell papulosis: an immunohistochemical study to determine histogenesis. J Cutan Pathol. 2002;29:11-14. (Pubitemid 34155163)
15. Yu Y, Sukhatme S, Loo DS. Clear cell papulosis: a connection of clear cells to Toker cells or Paget disease. Arch Dermatol. 2009;145: 1066-1067.
16. Saitoh A, Ohtake N, Fukuda S, et al. Clear cells of eccrine glands in a patient with clear cell syringoma associated with diabetes mellitus. Am J Dermatopathol. 1993;15:166-168. (Pubitemid 23109744)
17. Burket JM, Brooks R, Burket DA. Eccrine gland clear reticulated cytoplasm. J Am Acad Dermatol. 1985;13:497-500. (Pubitemid 15016495)
18. Requena L, Sarasa JL, Piqué E, et al. Clear cell porocarcinoma: another cutaneous marker of diabetes mellitus. Am J Dermatopathol. 1997;19: 540-544. (Pubitemid 27469757)
19. Abenoza P, Ackerman AB. Histologic features in eccrine units. In: Abenoza P, Ackerman AB, eds. Neoplasms with Eccrine Differentiation. Philadelphia, PA: Lea & Febiger; 1990:45-72.
20. Brownstein MH. The benign acanthomas. J Cutan Pathol. 1985;12: 172-188. (Pubitemid 15060883)
21. Petzelbauer P, Konrad K. Polypous clear cell acanthoma. Am J Dermatopathol. 1990;12:393-395. (Pubitemid 20218658)
22. Ohnishi T, Watanabe S. Immunohistochemical characterization of keratin expression in clear cell acanthoma. Br J Dermatol. 1995;133: 186-193.
23. Fukushiro S, Takei Y, Ackerman AB. Pale-cell acanthosis. A distinctive histologic pattern of epidermal epithelium. Am J Dermatopathol. 1985; 7:515-527. (Pubitemid 17138738)
24. Neuhaus IM, LeBoit PE, McCalmont TM. Seborrheic keratosis with basal clear cells: a distinctive microscopic mimic of melanoma in situ. J Am Acad Dermatol. 2006;54:132-135. (Pubitemid 41832470)
25. Barr RJ, Williamson C. Clear cell basal cell carcinoma (abstract). Arch Dermatol. 1984;120:1086.
26. Cohen RE, Zaim MT. Signet-ring clear cell basal cell carcinoma. J Cutan Pathol. 1988;15:183-187.
27. El-Shabrawi I, LeBoit PE. Basal cell carcinoma with thickened basement membrane: a variant that resembles some benign adnexal neoplasms. Am J Dermatopathol. 1997;19:568-574. (Pubitemid 27512406)
28. Barnabas MA, Freeman RG. Clear cell basal cell carcinoma: Light and electron microscopic study of an unusual variant. J Cutan Pathol. 1988; 15:1-7.
29. Oliver GF, Winkelmann RK. Clear cell basal cell carcinoma: histopathological, histochemical and electron microscopic findings. J Cutan Pathol. 1988;15:404-408. (Pubitemid 19026466)
30. Forman SB, Ferringer TC. Clear cell basal cell carcinoma: Differentiation from other clear cell tumors. Am J Dermatopathol. 2007;29: 208-209. (Pubitemid 46573096)
31. Barr RJ, Alpern KS, Santa Cruz DJ, et al. Clear cell basal carcinoma: an unusual degenerative variant. J Cutan Pathol. 1993;20:308-316. (Pubitemid 23249608)
32. Starink TM, Blomjous CEM, Stoof TJ, et al. Clear cell basal cell carcinoma. Histopathology. 1990;17:401-405.
33. Kuo T. Clear cell carcinoma of the skin: a variant of the squamous cell carcinoma that simulates sebaceous carcinoma. Am J Surg Pathol. 1980; 4:573-583. (Pubitemid 11104414)
34. Requena L, Sánchez M, Requena I, et al. Clear cell squamous cell carcinoma. A histologic, immunohistologic, and ultrastructural study. J Derm Surg Oncol. 1991;17:656-660.
35. Suster S. Clear cell tumors of the skin. Sem Diag Pathol. 1996;13:40-59. (Pubitemid 26051178)
36. Corbalan-Velez R, Ruiz-Macia JA, Brufau C, et al. Clear cells in cutaneous squamous cell carcinoma. Acta Dermatosifilogr. 2009;100: 307-316.
37. Cramer SF, Heggeness LM. Signet-ring squamous cell carcinoma. Am J Clin Pathol. 1988;91:488-491. (Pubitemid 19097084)
38. McKinley E, Valles R, Bang R, et al. Signet- ring squamous cell carcinoma: a case report. J Cutan Pathol. 1998;25:176-181. (Pubitemid 28130165)
39. Bastian BC, Kutzner H, Yen TSB, et al. Signet-ring cell formation in cutaneous neoplasms. J Am Acad Dermatol. 1999;41:606-613. (Pubitemid 29480413)
40. Al-Arashi MYH, Byers HR. Cutaneous clear cell squamous cell carcinoma in situ: clinical, histological and immunohistochemical characterization. J Cutan Pathol. 2007;4:226-233. (Pubitemid 46239311)
41. Williamson JD, Colome MI, Sahin A, et al. Pagetoid Bowen disease: a report of 2 cases that express cytokeratin 7. Arch Pathol Lab Med.
42. Mai KT, Alhalouly T, Landry D, et al. Pagetoid variant of actinic keratosis with or without squamous cell carcinoma of sun-exposed skin: a lesion simulating extramammary Paget's disease. Histopathology. 2002. 41. 331-336. (Pubitemid 35279030)
43. Dalton SR, LeBoit PE. Squamous cell carcinoma with clear cells: how often is there evidence of tricholemmal differentiation? Am J Dermatopathol. 2008;30:333-339.
44. Tronnier M. Clear cell trichoblastoma in association with a nevus sebaceous. Am J Dermatopathol. 2001;23:143-145. (Pubitemid 32319473)
45. Ackerman A, Reddy VB, Soyer HP. Neoplasms with Follicular Differentiation. 2nd ed. New York, NY: Ardor Sribendi Publishers; 2001.
46. Kazakhov D, Mentzel T, Erlandson RA, et al. Clear cell trichoblastoma: a clinicopathological and ultrastructural study of two cases. Am J Dermatopathol. 2006;28:197-201. (Pubitemid 44270853)
47. Wang L, Wang G, Yang L, et al. Multiple clear cell trichoblastoma. J Cutan Pathol. 2008;36:370-373.
48. Brownstein MH, Shapiro L. Tricholemmoma. Analysis of 40 new cases. Arch Dermatol. 1973;107:866-869.
49. Headington JT. Tumors of the hair follicle: a review. Am J Pathol. 1976; 85:480-514.
50. Boscaino A, Terracciano LM, Donofrio V, et al. Tricholemmal carcinoma: a study of seven cases. J Cutan Pathol. 1992;19:94-99.
51. Swanson PE, Marrogi AJ, Williams DJ, et al. Tricholemmal carcinoma: clinicopathologic study of 10 cases. J Cutan Pathol. 1992;19:100-109.
52. Reis JP, Tellechea O, Cunha MF, et al. Trichilemmal carcinoma: review of 8 cases. J Cutan Pathol. 1993;20:44-49. (Pubitemid 23092870)
53. Wong T-Y, Suster S. Tricholemmal carcinoma: a clinicopathologic study of 13 cases. Am J Dermatopathol. 1994;16:463-473. (Pubitemid 24323353)
54. Cassarino DS, DeRienzo DP, Barr RJ. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part I. J Cutan Pathol. 2006;33:191-206.
55. Crowson AN, Magro CN, Mihm MC. Malignant adnexal neoplasms. Mod Pathol. 2006;19:S93-S126. (Pubitemid 43172312)
56. Misago N, Ackerman AB. New quandary: tricholemmal carcinoma? Dermatopathol Pract Conceptual. 1999;5:463-473.
57. Wolfe JT III, Wick MR, Campbell RJ. Sebaceous carcinomas of the oculocutaneous adnexa and extra-ocular skin. In: Wick MR (ed). Pathology of Unusual Malignant Cutaneous Tumors. New York, NY: Marcel-Dekker; 1985:1163-1172. (Pubitemid 15003503)
58. Burgdorf WHC, Pitha J, Fahmy A. Muir-Torre syndrome: histologic spectrum of sebaceous proliferation. Am J Dermatopathol. 1986;8: 202-208. (Pubitemid 17049650)
59. Abbas O, Mahalingam M. Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm. J Cutan Pathol. 2009; 36:613-619.
60. Goette DK, Doty RD. Balloon cell nevus. Summary of the clinical and histologic characteristics. Arch Dermatol. 1978;114:109-111. (Pubitemid 8270049)
61. Headington JT, Koshi J, Murphy PJ. Clear cell glycogenesis in multiple syringomas. Description and enzyme histochemistry. Arch Dermatol. 1972;106:353-356.
62. Leibelman CE, Maize JC. Clear cell syringoma: A study by conventional and electron microscopy. Am J Dermatopathol. 1984;6:139-150. (Pubitemid 14134082)
63. Furue M, Hori Y, Nakabayashi Y. Clear cell syringoma. Association with diabetes mellitus. Am J Dermatopathol. 1984;6:131-138. (Pubitemid 14134081)
64. Kitamura K, Muraki R, Tamura N. Clear cell syringoma. Cutis. 1983;32: 169-172. (Pubitemid 13037122)
65. Ambrojo P, Requena Caballero L, Aquilar Martinez A, et al. Clear cell syringoma. Immunohistochemical and electron microscopy study. Dermatologica. 1989;178:164-166. (Pubitemid 19104312)
66. Ohnishi T, Watanabe S. Immunohistochemical analysis of keratin expression in clear cell syringoma. A comparative study with conventional syringoma. J Cutan Pathol. 1997;24:370-376. (Pubitemid 27312018)
67. Liu Y. The histogenesis of clear cell papillary carcinoma of the skin. Am J Pathol. 1949;25:93-103.
68. Keasbey LE, Hadley GG. Clear cell hidradenoma. Report of three cases with widespread metastases. Cancer. 1954;7:934-952.
69. Johnson BL, Helwig EB. Eccrine acrospiroma. A clinicopathologic study. Cancer. 1969;23:641-657.
70. Lever WF, Castleman B. Clear cell myoepithelioma of the skin. Am J Pathol. 1952;28:691-699.
71. Winkelmann RK, Wolff K. Solid cystic hidradenoma of the skin. Arch Dermatol. 1968;97:651-661.
72. O'Hara JM, Bensch K, Ioannides G, et al. Eccrine sweat gland adenoma, clear cell type. Cancer. 1966;19:1438-1450.
73. Hashimoto K, Mehregan AH, Kumakiri M. Eccrine gland tumors. In Tumors of Skin Appendages. Stoneham, MA. Butterworth Publishers; 1987:14-84.
74. Satoh T, Katsumata M, Tokura Y, et al. Clear cell hidradenoma with whorl formation of squamous cells: immunohistochemical and electron microscopic studies. J Am Acad Dermatol. 1989;21:271-277. (Pubitemid 19195890)
75. Hashimoto K, Di Bella RJ, Lever WF. Clear cell hidradenoma. Histologic, histochemical and electron microscopic study. Arch Dermatol. 1967;96:18-38.
76. Ohnishi T, Watanabe S. Histogenesis of clear cell hidradenoma: Immunohistochemical study of keratin expression. J Cutan Pathol. 1997;24:30-36. (Pubitemid 27060074)
77. Gianotti R, Alessi E. Clear cell hidradenoma associated with the folliculo-sebaceous-apocrine unit. Histologic study of five cases. Am J Dermatopathol. 1997;19:351-357. (Pubitemid 27467160)
78. Nazarian RM, Kapur P, Rakheja D, et al Atypical and malignant hidradenomas: a histological and immunohistochemical study. Mod Pathol. 2009;22:600-610.
79. Wong T-Y, Suster S, Nogita T, et al. Clear cell eccrine carcinomas of the skin. Cancer. 1994;73:1631-1643.
80. Kazakhov DV, IVan D, Kutzner H, et al. Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her 2/neu gene expression/amplification, TP53 gene mutation analysis, and t (11; 19) translocation. Am J Dermatopathol. 2009;31:236-247.
81. Behboudi A,Winnes M, Gorunova L, et al. Clear cell hidradenoma of the skin-a third tumor type associated with a t (11; 19) associated TORC1- MAML2 gene fusion. Genes Chromosomes Cancer. 2005;43:202-205. (Pubitemid 40570740)
82. Seethala RR, Dacic S, Cieply K, et al. A reappraisal of the MECT1/ MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol. 2010;34:1106-1121.
83. Chaudhry IH, Zembowicz A. Adnexal clear cell carcinoma with comedonecrosis: clinicopathologic analysis of 12 cases. Arch Pathol Lab Med. 2007;131:1655-1664. (Pubitemid 350077462)
84. LeBoit PE, Sexton M. Microcystic adnexal carcinoma of the skin. J Am Acad Dermatol. 1993;29:609-618.
85. Revercomb CH, Reitmeyer WJ, Pulitzer DR. Clear cell variant of mucoepidermoid carcinoma of the skin. J Am Acad Dermatol. 1993;29: 642-644. (Pubitemid 23289568)
86. Rü tten A, Hantschke M, Angulo J, et al. Clear cell dermal duct tumour: another distinctive, previously underrecognized cutaneous adnexal neoplasm. Histopathology. 2007;51:805-813. (Pubitemid 350179416)
87. Lan C-C E, Yu H-S, Liao W-T, et al. Clear cell eccrine porocarcinoma with extensive cutaneous metastasis and peripheral lymphocyte dysfunction. Br J Dermatol. 2003;149:1059-1063. (Pubitemid 37541996)
88. Rü tten A, Requena L, Requena L. Clear cell porocarcinoma in situ: a cytologic variant of porocarcinoma in situ. Am J Dermatopathol. 2002; 24:67-71. (Pubitemid 34121792)
89. Sitakalin C, Ackerman AB. Mammary and extramammary Paget's disease. Am J Dermatopathol. 1985;7:335-340.
90. Lundquist K, Kohler S, Rouse RV. Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Am J Surg Pathol. 1999;23:212-219. (Pubitemid 29075163)
91. Gleason BC, Hornick JL. Myoepithelial tumours of skin and soft tissue: an update. Diag Histopathol. 2008;14:552-562.
92. Hornick JL, Fletcher CDM. Cutaneous myoepithelioma: a clinicopathologic and immunohistochemical study of 14 cases. Hum Pathol. 2004; 35:14-24. (Pubitemid 38133918)
93. Hornick JL, Fletcher CDM. Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J Surg Pathol. 2003;27: 1183-1196. (Pubitemid 37040580)
94. Stojsic Z, Brasanac D, Boricic I, et al. Clear cell myoepithelial carcinoma of the skin. A case report. J Cutan Pathol. 2009;36:680-683.
95. Imlay SP, Argenyi ZB, Stone MS, et al. Cutaneous parachordoma. A light microscopic and immunohistochemical report of two cases and review of literature. J Cutan Pathol. 1998;25:279-284. (Pubitemid 28306519)
96. Kilpatrick SE, Limon J. Mixed tumour/myoepithelioma/parachordoma. In: Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press; 2002:198-199.
97. Guedes A, Barreto BG, Barreto LG, et al. Metastatic parachordoma. J Cutan Pathol. 2009;36:270-273.
98. Zelger B, Steiner H, Kutzner H. Clear cell dermatofibroma. Case report of an unusual fibriohistiocytic lesion. Am J Surg Pathol. 1996;20: 483-491. (Pubitemid 26113356)
99. Wambacher-Gasser B, Zelger B, Zelger BG, et al. Clear cell dermatofibroma. Histopathology. 1997;30:64-69. (Pubitemid 27072450)
100. Tran TA, Hayner-Buchan A, Jones DM, et al. Cutaneous balloon cell dermatofibroma (fibrous histiocytoma). Am J Dermatopathol. 2007;29: 197-200. (Pubitemid 46573095)
101. McKee PH, Calonje E, Granter SR. Connective tissue tumors. In: McKee PH, Calonje E, Granter SR, eds. Pathology of the Skin; with Clinical Correlations. 3rd ed. Philadelphia, PA: Elsevier Mosby; 1751.
102. Patterson JW, Konerding H, Kramer WM. "Clear cell" atypical fibroxanthoma. J Dermatol Surg Oncol. 1987;13:1109-1114.
103. Murali R, Palfreeman. Clear cell atypical fibroxanthoma-report of a case with review of the literature. J Cutan Pathol. 2006;33:343-348.
104. Requena L, Sanqueza OP, Sanchez Yus E, et al. Clear cell atypical fibroxanthoma: an unusual histopathologic variant of atypical fibroxanthoma. J Cutan Pathol. 1997;24:176-182 (Pubitemid 27117374)
105. Lázaro-Santander R, Andrés-Gozalbo C, Rodríguez- Pereira C, et al. Clear cell atypical fibroxanthoma. Histopathology. 1999;35:484-485.
106. Crowson AN, Carlson-Sweet K, Macinnis C, et al. Clear cell atypical fibroxanthoma: a clinicopathologic study. J Cutan Pathol. 2002;29: 374-381.
107. Kemmerling R, Dietze O, Mü ller S, et al. Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear cell atypical fibroxanthoma. Pathol Res Pract. 2009;205:365-370.
108. de Feraudy S, Mar N, McCalmont T. Evaluation of CD10 and procollagen1 expression in atypical fibroxanthoma and dermatofibroma. Am J Surg Pathol. 2008;32:1111-1122.
109. Mathew RA, Schlauder SM, Calder KB, et al. CD117 immunoreactivity in atypical fibroxanthoma. Am J Dermatopathol. 2008;30:34-36. (Pubitemid 351161628)
110. Northcutt AD. Epidermotropic xanthoma mimicking balloon cell melanoma. Am J Dermatopathol. 2000;22:176-178. (Pubitemid 30185843)
111. Puri PK, Tyler WB, Ferringer TC. Neurofibroma with clear cell change. Am J Dermatopathol. 2009;31:453-456.
112. Zedek DC, Murphy BA, Shea CR, et al. Cutaneous clear cell granular cell tumor: the histologic description of an unusual variant. J Cutan Pathol. 2006;34:397-404.
113. Soyer HP, Kutzner H, Metze D, et al. Fibrous papule with clear fibrocytes. Dermatopathol Pract Conceptual. 1997;3:110-113.
114. Dei Tos AP. Liposarcoma: new entities and evolving concepts. Ann Diagn Pathol. 2000;4:252-266.
115. Dei Tos AP, Mentzel T, Fletcher CDM. Primary liposarcoma of the skin: a rare neoplasm with unusual high grade features. Am J Dermatopathol. 1998;20:332-338. (Pubitemid 28363613)
116. Val-Bernal JF, González-Vela MC, Cuevas J. Primary purely intradermal pleomorphic liposarcoma. J Cutan Pathol. 2003;30:516-520. (Pubitemid 37129902)
117. Mentzel T, Reisshauer S, Rü tten A, et al. Cutaneous clear cell myomelanocytic tumour: a new member of the growing family of perivascular epithelioid cell tumours (PEComas). Clinicopathological and immunohistohemical analysis of seven cases. Histopathology. 2005; 46:498-504. (Pubitemid 40632306)
118. Liegl B, Hornick JL, Fletcher CDM. Primary cutaneous PEComa: distinctive clear cell lesions of skin. Am J Surg Pathol. 2008;32:608-614. (Pubitemid 351458303)
119. Calder KB, Schlauder S, MorganMB. Malignant perivascular epithelioid cell tumor (-PEComa-): a case report and literature review of cutaneous/ subcutaneous presentations. J Cutan Pathol. 2007;35:499-503.
120. Lazar AJ, Fletcher CD. Distinctive dermal clear cell mesenchymal neoplasm: clinicopathologic analysis of five cases. Am J Dermatopathol. 2004;26:273-279. (Pubitemid 38989022)
121. Schrader WA, Helwig EB. Balloon cell nevi. Cancer. 1967;20: 1502-1514.
122. Smoller BR, Kindel S, McNutt NS, et al. Balloon cell transformation in multiple dysplastic nevi. J Am Acad Dermatol. 1991;24:290-292.
123. Borsa S, Toonstra J, Van Der Putte SC, et al. Balloon cell variant of Spitz nevus. Hautarzt. 1991;42:707-708 [article in German].
124. McGowan JW, Smith MK, Ryan M, et al. Proliferative nodules with balloon cell change in a large congenital melanocytic nevus. J Cutan Pathol. 2006;33:253-255.
125. Perez MT, Suster S. Balloon cell change in cellular blue nevus. Am J Dermatopathol. 1999;21:181-184. (Pubitemid 29162881)
126. Laaff H, Kuhnl-Petzoldt C. HMB-45 positive balloon cells in combined nevi. Hautarzt. 1992;43:566-568 [article in German].
127. Cô té J, Watters AK, O'Brien EA. Halo balloon cell nevus. J Cutan Pathol. 1986;13:123-127. (Pubitemid 16047696)
128. LiVolsi VA, Brooks JJ, Soslow R, et al. Signet ring cell melanocytic lesions. Mod Pathol. 1992;5:515-520.
129. Meischer G. Umwandlung von Naevuszellen in Talgdrusenzellen. Arch Dermatol Syphil. 1935;171:119-124 [article in German].
130. Hashimoto K, Bale GE. An electron microscopic study of balloon cell nevus. Cancer. 1972;30:530-540.
131. Kim YJ, Kim YC, Kang HY. Is apoptosis involved in the development of balloon cell nevus? Suggestion from a case report. J Am Acad Dermatol. 2007;56:1069-1070. (Pubitemid 46720198)
132. Kao GF, Helwig EB, Graham JH. Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical and ultrastructural observations. Cancer. 1992; 69:2942-2952.
133. Sheibani K, Battifora H. Signet ring cell melanoma. A rare morphologic variant of malignant melanoma. Am J Surg Pathol. 1988;12:28-34. (Pubitemid 18024371)
134. GardnerWA, Vazquez M. Balloon cell melanoma. Arch Pathol Lab Med. 1970;89:470-472.
135. Requena L, de la Cruz A, Moreno C, et al. Animal type melanoma. A report of a case with balloon-cell change and sentinel lymph node metastasis. Am J Dermatopathol. 2001;23:341-346. (Pubitemid 32729446)
136. Magro CM, Crowson AN, Mihm MC. Unusual variants of malignant melanoma. Mod Pathol. 2006;19:S41-S70. (Pubitemid 43172309)
137. Peters MS, Su WPD. Balloon cell malignant melanoma. J Am Acad Dermatol. 1985;13:351-354. (Pubitemid 16217376)
138. Ranchod M. Metastatic melanoma with balloon cell changes. Cancer. 1972;30:1006-1013.
139. Plaza JA, Torres-Cabala C, EVans H, et al. Cutaneous metastases of malignant melanoma: a clinicopathologic study of 192 cases with emphasis on the morphologic spectrum. Am J Dermatopathol. 2010;32: 129-136.
140. Gregel C, Wolter M, Kaufmann R. Coincidence of balloon cell melanoma with balloon cells in a dermal nevus. Pathologe. 1998;19: 151-153 [article in German]. (Pubitemid 28125885)
141. Al-Talib RK, Theaker JM. Signet-ring melanoma: light microscopic, immunohistochemical and ultrastructural features. Histopathology 1991; 18:572-575.
142. Meis-Kindblom JM. Clear cell sarcoma of the tendons and aponeuroses: a historical perspective and tribute to the man behind the entity. Adv Anat Pathol. 2006;13:286-292. (Pubitemid 44673444)
143. Panagopoulos I, Mertens F, Debiec-Rychter M, et al. Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of the tendons and aponeuroses. Int J Cancer. 2002;99:560-567. (Pubitemid 34461609)
144. Panagopoulos I, Mertens F, Isaksson M, et al. Absence of mutations of the BRAF gene in malignant melanoma of soft parts (clear cell sarcoma of tendon and aponeuroses). Cancer Genet Cytogenet. 2005; 156:74-76. (Pubitemid 39601063)
145. Hantschke M, Mentzel T, Rütten A, et al. Cutaneous clear cell sarcoma: A clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma. Am J Surg Pathol. 2010;34:216-222.
146. McKee PH. Cutaneous metastases. J Cutan Pathol. 1985;12:239-250. (Pubitemid 15060889)