How staphylococcus aureus breaches our skin to cause infection

Journal of Infectious Diseases

Volumn 205, Issue 10, 2012, Pages 1483-1485

  Otto, Michael ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CASPASE 3; CATHELICIDIN; DEFENSIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PANTON VALENTINE LEUKOCIDIN; PHENOL SOLUBLE MODULIN ALPHA; PROGRAMMED DEATH 1 RECEPTOR; STAPHYLOCOCCUS ALPHA TOXIN; STAPHYLOCOCCUS PROTEIN A; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; APOPTOSIS; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL SKIN DISEASE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; COMMUNICABLE DISEASE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; CYTOTOXICITY; GENETIC CODE; HOSPITAL INFECTION; HOST PATHOGEN INTERACTION; HUMAN; INFECTION SENSITIVITY; KERATINOCYTE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN ABSCESS; SKIN PERMEABILITY; SOFT TISSUE INFECTION;

CALPAIN; CASPASE 1; HUMANS; KERATINOCYTES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS;

EID: 84860376453     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis248     Document Type: Note

References (18)

1. DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated methicillin-resistant Staphylococcus aureus. Lancet 2010; 375: 1557-68.
2. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 2006; 355:666-74.
3. Otto M. Basis of virulence in communityassociated methicillin-resistant Staphylococcus aureus. Annu Rev Microbiol 2010; 64: 143-62.
4. Kobayashi SD, Malachowa N, Whitney AR, et al. Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis 2011; 204:937-41.
5. Ventura CL, Malachowa N, Hammer CH, et al. Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics. PLoS One 2010; 5: e11634.
6. Dumont AL, Nygaard TK, Watkins RL, et al. Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis. Mol Microbiol 2011; 79:814-25.
7. Kennedy AD, Bubeck Wardenburg J, Gardner DJ, et al. Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis 2010; 202: 1050-8.
8. Wang R, Braughton KR, Kretschmer D, et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 2007; 13:1510-4.
9. Bubeck Wardenburg J, Bae T, Otto M, DeLeo FR, Schneewind O. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med 2007; 13:1405-6.
10. Li M, Diep BA, Villaruz AE, et al. Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci USA 2009; 106:5883-8.
11. Valeva A, Walev I, Pinkernell M, et al. Transmembrane beta-barrel of staphylococcal alpha-toxin forms in sensitive but not in resistant cells. Proc Natl Acad Sci USA 1997; 94:11607-11.
12. Wilke GA, Bubeck Wardenburg J. Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysinmediated cellular injury. Proc Natl Acad Sci USA 2010; 107:13473-8.
13. Kretschmer D, Gleske AK, Rautenberg M, et al. Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus. Cell Host Microbe 2010; 7:463-73.
14. Harder J, Schroder JM. Antimicrobial peptides in human skin. Chem Immunol Allergy 2005; 86:22-41.
15. Nizet V, Ohtake T, Lauth X, et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001; 414:454-7.
16. Shimada T, Park BG, Wolf AJ, et al. Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. Cell Host Microbe 2010; 7:38-49.
17. Walev I, Martin E, Jonas D, et al. Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions. Infect Immun 1993; 61: 4972-9.
18. Gomez MI, Lee A, Reddy B, et al. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat Med 2004; 10:842-8.