Mathematical modeling of diffuse brain injury: Correlations of foci and severity of brain strain with clinical symptoms and pathology

2011 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury

Volumn , Issue , 2011, Pages 315-324

  Zhang, Liying ^a   Gennarelli, Thomas A ^b  

^a Wayne State University   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Brain; Brain strain; Concussion; Diffuse axonal injury; Diffuse brain injury; Finite element head model; Head acceleration

Indexed keywords

BRAIN INJURY; BRAIN VOLUME; CLINICAL SYMPTOMS; CONCUSSION; CORPUS CALLOSUM; DIFFUSE AXONAL INJURY; FINITE ELEMENT MODELS; HEAD MODEL; HUMAN HEAD; LOADING CONDITION; LOADING DIRECTION; MATHEMATICAL MODELING; MAXIMUM PRINCIPAL STRAIN; MIDBRAIN; OBLIQUE PLANES; PEAK THRESHOLD; STRAIN DISTRIBUTIONS; TISSUE INJURY; WAYNE STATE UNIVERSITY;

BIOMECHANICS; DISEASES; LOADING; PATHOLOGY; STRAIN; TISSUE;

BRAIN;

EID: 84860374877     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (42)

1. Gennarelli TA, Cerebral concussion and diffuse brain injury, In: Head Injury, 137-158, Cooper PR, Williams and Wilkins, Baltimore, 1993.
2. Christman CW, Grady MS, Walker SA, Holloway KL, Povlishock JT, Ultrastructural studies of diffuse axonal injury in human, J Neurotrauma, 11, 173-186, 1994.
3. Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, McLean AJ, Staining of amyloid precursor protein to study axonal damage in mild head injury, Lancet, 344, 1055-1056, 1994.
4. Adams JH, Graham DI, Murray LS, Scott G, Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases, Annals of Neurology, 12, 557-563, 1982.
5. Gennarelli TA, Thibault LE, Adams JH, Graham DI, Thompson CJ, Marcincin RP, Diffuse axonal injury and traumatic coma in the primate, Annals of Neurology, 12, 564-574, 1982.
6. Ommaya AK, Yarnell P, Hirsch AE, Harris EH, Scaling of experimental data on cerebral concussion in subhuman primates to concussion threshold for man, 11th Stapp Car Crash Conference, SAE 670906, 1967.
7. Ommaya AK, Gennarelli TA, Cerebral concussion and traumatic unconsciousness: correlation of experimental and clinical observations of blunt head injuries, Brain, 97, 633-654, 1974.
8. Lowenhielm P, Mathematical simulation of gliding contusions, J Biomechanics, 81, 351-356, 1975.
9. Löwenhielm P, Tolerance level for bridging vein disruption calculated with a mathematical model, J Bioeng, 2, 501-507, 1978.
10. Margulies SS, Thibault LE, A proposed tolerance criterion for diffuse axonal injury in man, J Biomech, 25, 917-923, 1992.
11. Newman J, Shewchenko N, Welbourne E, A proposed new biomechanical head injury assessment functionthe maximum power index, Stapp Car Crash Journal, 44, 215-247, 2000.
12. Zhang L, Yang KH, King AI, A proposed injury threshold for mild traumatic brain injury, J Biomechanical Engineering, 126(2), 226-236, 2004.
13. Gennarelli, TA, Pintar FA, Yoganandan N, Biomechanical tolerances for diffuse brain injury and a hypothesis for genotypic variability in response to trauma, Proceedings of Assoc Adv Automotive Med, 47, Lisbon, Portugal, 624-628, 2003.
14. Ommaya AK, Goldsmith W, Thibault L, Biomechanics and neuropathology of adult and paediatric head injury, British J Neurosurgery, 16(3), 220-242, 2002.
15. Plum F, Posner JB, The diagnosis of stupor and coma, 3rd ed. Philadelphia: FA Davis, 1980.
16. Bernat JL, Question remaining about the minimally conscious state, Neurology, 58, 337-338, 2002.
17. th Stapp Car Crash Conference, SAE 942215, 1994.
18. Kleiven S, Hardy WN. Correlation of an FE model of the human head with local brain motion - consequences for injury prediction. Stapp Car Crash Journal, 46, 123-144, 2002.
19. Takhounts EG, Eppinger RH, Campbell JQ, Tannous RE, Power ED, Shock LS, On the development of the SIMon finite element head model, Stapp Car Crash Journal, 47, 107-133, 2003.
20. Viano DC, Casson IR Pellman EJ, Zhang L, Yang KH, King AI, Concussion in professional football: Brain responses by finite element analysis - Part 9, Neurosurgery, 57, 891-916, 2005.
21. Zhang L, Yang KH, Gennarelli T, Mathematical modeling of cerebral concussion: Correlations of regional brain strain with clinical symptoms, Proceeding of IRCOBI Conference, Bern, Switzerland, 2008.
22. Zhang L, Yang KH, Dwarampudi R, Omori K, Li T, Chang K, Hardy WN, Khalil TB, King AI, Recent advances in brain injury research: A new human head model development and validation, Stapp Car Crash Journal, 45, 369-393, 2001.
23. Gennarelli TA, Wodzin E, Abbreviated Injury Scale 2005, Association for the Advancement of Automotive Medicine, 51, Barrington, IL, 2005.
24. Zhang L, Yang KH, King AI, Viano DC, A new biomechanical predicator for mild traumatic brain injury - A preliminary finding, ASME Bioengineering Conference Proceedings, Key Biscayne, FL, USA, 2003.
25. King AI, Yang KY, Zhang L, Hardy WN, Viano DC, Is head injury caused by linear or angular acceleration? Bertil Aldman Lecture, International IRCOBI Conference on the Biomechanics of Impact, 2003.
26. Franklyn M, Fildes B, Zhang L, Yang KH, Sparke L, Analysis of finite element models for head injury investigation: Reconstruction of four real-world impacts, Stapp Car Crash Journal, 49, 1-32, 2005.
27. Zhang L, Franklyn M, Yang K, Head Injury prediction: Accident reconstruction of real-world crash cases, Proceedings of 8th International World Congress on Brain Injury, Washington DC, USA, 2010.
28. Adams JH, Mitchell DE, Graham DI, Doyle D, Diffuse brain damage of immediate impact type: its relation to primary brainstem damage in head injury, Brain, 100, 489-502, 1977.
29. Gennarelli TA, Thibault LE, Tomei G, Wiser R, Graham D, Adams J, Directional dependence of axonal brain injury due to centroidal and non-centroidal acceleration, Stapp Car Crash Conference, New Orleans, LA, USA, 49-53, 1987.
30. Gentry LR, Gordersky JC, Trauma to the corpus callosum: MR features, Am. J. Neuroradiology, 9, 1129-1138, 1988.
31. Maxwell WL, Povlishock JT, Graham DL, A mechanistic analysis of nondestructive axonal injury: A review, J Neurotrauma, 14(7), 419-440, 1997.
32. Petrides M, Impairments on nonspatial self-ordered and externally ordered working memory tasks after lesions of the mid-dorsal part of the lateral frontal cortex in the monkey, J Neuroscience, 15, 359-375, 1995.
33. Stuss DT, Bension DF, The frontal lobes, Raven Press, New York, 1986.
34. Devinsky O, Morrel MJ, Vogt BA, Contributions of anterio cigulate cortex to behavior, Brain, 118, 279-306, 1995.
35. Adams JH, Graham DI and Jennett B, The neuropathology of the vegetative state after acute brain insults, Brain, 123, 1327-1338, 2000.
36. Adams JH, Graham DI and Jennett B, The structural basis of moderate disability following traumatic brain damage, J Neurol Neurosurg Psychiatry, 71, 521-524, 2001.
37. Adams JH, Jennet B, Murray LS, Teasdale GM, Gennarelli TA, Graham DI, Neuropathological findings in disabled survivors of a head injury, J Neurotrauma, 28(5), 701-709, 2011.
38. Graham, DI, Gennarelli, TA, McIntosh, TK, Trauma in Greenfield's Neuropathology Seventh Edition, Chapter 14, 823-898, DI Graham and PL Lantos, Arnold, London, 2002.
39. Smith DH, Wolf JA, Lusardi TA, Lee VMY, Meaney DF, High tolerance and delayed elastic response of cultured axons to dynamic stretch injury, J Neuroscience, 19, 4263-4269, 1999.
40. Bain AC, Meaney DF, Thresholds for mechanical injury to the in vivo white matter, Proceedings of 43rd Stapp Car Crash Conference, SAE Paper 99SC19, 1999.
41. Elkin BS, Morrison B, Region-specific tolerance criteria for the living brain, Stapp Car Crash Journal, 51, 127-138, 2007.
42. Tamura A, Nagayama K, Matsumoto T, Hayashi S, Variation in nerve fiber strain in brain tissue subjected to uniaxial stretch, Stapp Car Crash Journal, 51, 139-154, 2007.