Morphological abnormalities in baseline ECGs in healthy normal volunteers participating in phase I studies

Indian Journal of Medical Research

Volumn 135, Issue 3, 2012, Pages 322-330

  Hingorani, Pooja ^a   Natekar, Mili ^a   Deshmukh, Sheetal ^a   Karnad, Dilip R ^a   Kothari, Snehal ^a   Narula, Dhiraj ^a   Lokhandwala, Yash ^a  

^a IQVIA   (United States)

Author keywords

Age distribution; Clinical trials; Electrocardiography; Healthy population; Sex distribution

Indexed keywords

ALKALINE PHOSPHATASE; AMINOTRANSFERASE; BILIRUBIN; CREATININE; HEMOGLOBIN;

ADULT; AGED; AIR FORCE; ATHLETE; ATRIOVENTRICULAR BLOCK; CARDIOLOGIST; CONTROLLED STUDY; ECG ABNORMALITY; ELECTROCARDIOGRAPHY MONITORING; FEMALE; FOLLOW UP; HEART ATRIUM ENLARGEMENT; HEART ATRIUM FIBRILLATION; HEART CONDUCTION; HEART RATE; HEART RHYTHM; HEART RIGHT BUNDLE BRANCH BLOCK; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE EXTRASYSTOLE; HEMATOCRIT; HUMAN; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PHYSICAL EXAMINATION; PR INTERVAL; PRACTICE GUIDELINE; RETROSPECTIVE STUDY; REVIEW; SCREENING TEST; SINUS BRADYCARDIA; SINUS TACHYCARDIA; ST SEGMENT; STRUCTURE ANALYSIS; T WAVE; THROMBOCYTE COUNT;

ADULT; AGE FACTORS; AGED; ARRHYTHMIAS, CARDIAC; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; INDIA; MALE; MIDDLE AGED; SEX FACTORS;

EID: 84860359582     PISSN: 09715916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Hiss RG, Lamb LE. Electrocardiographic findings in 122,043 individuals. Circulation 1962; 25: 947-61.
2. De Bacquer D, De Backer G, Kornitzer M. Prevalence of ECG findings in large population based samples of men and women. Heart 2000; 84: 625-33.
3. Pelliccia A, Culasso F, Di Paolo FM, Accettura D, Cantore R, Castagna W, et al. Prevalence of abnormal electrocardiograms in a large, unselected population undergoing pre-participation cardiovascular screening. Eur Heart J 2007; 28: 2006-10.
4. Pelliccia A, Di Paolo FM, Quattrini FM, Basso C, Culasso F, Popoli G, et al. Outcomes in athletes with marked ECG repolarization abnormalities. N Engl J Med 2008; 358: 152-61.
5. th ed. Philadelphia: Saunders Elsevier; 2008.
6. Dmitrienko AA, Sides GD, Winters KJ, Kovacs RJ, Rebhun DM, Bloom JC, et al. Electrocardiogram reference ranges derived from a standardized clinical trial population. Drug Inf J 2005; 39: 395-405.
7. Mason JW, Ramseth DJ, Chanter DO, Moon TE, Goodman DB, Mendzelevski B. Electrocardiographic reference ranges derived from 79,743 ambulatory subjects J Electrocardiol 2007; 40: 228-34.
8. Britton A, Shipley M, Malik M, Hnatkova K, Hemingway H, Marmot M. Changes in heart rate and heart rate variability over time in middle-aged men and women in the general population (from the Whitehall II Cohort Study). Am J Cardiol 2007; 100: 524-7.
9. Liao YL, Emidy LA, Dyer A, Hewitt JS, Shekelle RB, Paul O, et al. Characteristics and prognosis of incomplete right bundle branch block: an epidemiologic study. J Am Coll Cardiol 1986; 7: 492-9.
10. Yano K, Peskoe SM, Rhoads GG, Moore JO, Kagan A. Left axis deviation and left anterior hemiblock among 8,000 Japanese-American men. Am J Cardiol 1975; 35: 809-15.
11. Möhlenkamp S, Schmermund A, Lehmann N, Roggenbuck U, Dragano N, Stang A, et al for the Heinz Nixdorf Recall Study Investigators. Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population. Atherosclerosis 2008; 196: 786-94.
12. Ostrander LD Jr, Brandt RL, Kjelsberg MO, Epstein FH. Electrocardiographic findings among the adult population of a total natural community, Tecumseh, Michigan. Circulation 1965; 31: 888-98.
13. Vitelli LL, Crow RS, Shahar E, Hutchinson RG, Rautaharju PM, Folsom AR, for the atherosclerosis risk in communities (ARIC) study investigators. Electrocardiographic findings in a healthy biracial population. Am J Cardiol 1998; 81: 453-9.
14. Cullen K, Stenhouse NS, Wearne KL, Cumpston GN. Electrocardiograms and 13 year cardiovascular mortality in Busselton study. Br Heart J 1982; 47: 209-12.
15. Mymin D, Mathewson FA, Tate RB, Manfreda J. The natural history of primary first-degree atrioventricular heart block. N Engl J Med 1986; 315: 1183-7.
16. Liu S, Yuan S, Kongstad O, Olsson SB. Gender differences in the electrophysiological characteristics of atrioventricular conduction system and their clinical implications. Scand Cardiovasc J 2001; 35: 313-7.
17. Wu J, Kors JA, Rijnbeek PR, van Herpen G, Lu Z, Xu C. Normal limits of the electrocardiogram in Chinese subjects. Int J Cardiol 2003; 87: 37-51.
18. Romhilt DW, Bove KE, Norris RJ, Conyers E, Conradi S, Rowlands DT, et al. A critical appraisal of the electrocardiographic criteria for the diagnosis of left ventricular hypertrophy. Circulation 1969; 40: 185-95.
19. Rose G, Baxter PJ, Reid DD, McCartney P. Prevalence and prognosis of electrocardiographic findings in middle-aged men. Br Heart J 1978; 40: 636-43.
20. Macfarlane PW. Minnesota coding and the prevalence of ECG abnormalities. Heart 2000; 84: 582-4.
21. Moss AJ. Measurement of the QT interval and the risk associated with QTc interval prolongation: a review. Am J Cardiol 1993; 72: 23B-5B.
22. Bjerregaard P. Premature beats in healthy subjects 40-79 years of age. Eur Heart J 1982; 3: 493-503.
23. Stinson JC, Pears JS, Williams AJ, Campbell RW. Use of 24 h ambulatory ECG recordings in the assessment of new chemical entities in healthy volunteers. Br J Clin Pharmacol 1995; 39: 651-6.
24. Orth-Gomer K, Hogstedt C, Bodin L, Söderholm B. Frequency of extrasystoles in healthy male employees. Br Heart J 1986; 55: 259-64.
25. Panicker GK, Karnad DR, Joshi R, Shetty S, Vyas N, Kothari S, et al. Z-score for benchmarking reader competence in a central ECG laboratory. Ann Noninvasive Electrocardiol 2009; 14: 19-25.
26. th ed. Philadelphia, Pa: WB Saunders Co., 2005. p. 107-52.
27. th ed. Philadelphia: Lippincott Williams & Wilkans; 2001.
28. th ed. Philadelphia, Pa: WB Saunders Co.; 2005. p. 803-63.
29. Barker JM, Valencia F. The precordial electrocardiogram in incomplete right bundle branch block. Am Heart J 1949; 38: 376-406.
30. th ed. Oxford: Wiley-Blackwell Scientific Publications; 1990.