Electrocardiogram reference ranges derived from a standardized clinical trial population

Drug Information Journal

Volumn 39, Issue 4, 2005, Pages 395-405

  Dmitrienko, Alexei A ^a   Sides, Gregory D ^a   Winters, Kenneth J ^a   Kovacs, Richard J ^b   Rebhun, Dawn M ^a   Bloom, John C ^a   Groh, William ^b   Eisenberg, Paul R ^a  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clinical trials; Electrocardiograms; QT interval; Reference ranges

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL RESEARCH; CLINICAL TRIAL; DIAGNOSTIC ACCURACY; ELECTROCARDIOGRAM; FEMALE; HEART ARRHYTHMIA; HEART RATE; HEART REPOLARIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT CARE; PR INTERVAL; PRIORITY JOURNAL; PROGNOSIS; QRS COMPLEX; QT INTERVAL; REFERENCE VALUE; RISK ASSESSMENT; RISK FACTOR; STANDARDIZATION;

EID: 27744576792     PISSN: 00928615     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Macfarlane PW, Lawie TDV. Comprehensive Electrocardiography: Theory and Practice in Health and Disease. Oxford, UK: Pergamon Press; 1989.
2. Sagie A, Larson MG, Goldberg RJ, Bengtson JR, Levy D. An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol. 1992;70:797-801.
3. Rijnbeek PR, Witsenburg M, Schrama E, Hess J, Kors JA. New normal limits for the paediatric electrocardiogram. Eur Heart J. 2001;22:702-711.
4. Rautaharju PM, Zhou SH, Wong S, et al. Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol. 1992;8:690-695.
5. International Conference on Harmonisation. The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-antiarrhythmic Drugs (ICH E14). May 12, 2005.
6. Bazett HC. An analysis of time relations of electrocardiograms. Heart. 1920;7:353-367.
7. Fridericia LS. Die Systolendauer im Elecktrokardiogramm bei normalen Menschen und bei Herzkranken. Acta Medica Scand. 1920;53:469-486.
8. Puddu PE, Jouve R, Mariotti S, et al. Evaluation of 10 QT prediction formulas in 881 middle-aged men from the seven countries study: emphasis on the cubic root Fridericia's equation. J Electrocardiol. 1988;21:219-229.
9. Davignon A, Rautaharju P, Boisselle E, Soumis F, Megelas M, Choguette A. Normal ECG standards for infants and children. Pediatr Cardiol. 1979/ 1980;1:123-131.
10. Macfarlane PW, Coleman EN, Pomphrey EO, McLaughlin S, Houston A, Aitchison T. Normal limits of the high-fidelity pediatric ECG. Preliminary observations. J Electrocardiol. 1989;22:162-168.
11. Hodges M, Salerno D, Erlien D. Bazett's QT correction reviewed: evidence that a linear correction for heart rate is better. J Am Coll Cardiol. 1983;1:694.
12. Malik M. If Dr. Bazett had had a computer... Pacing Clin Electrophysiol. 1996;19:1635-1639.
13. B. Malik M. Problems of heart rate correction in the assessment of drug-induced QT interval prolongation. J Cardiovasc Electrophysiol. 2001;12:411-420.
14. Simonson E. Differentiation Between Normal and Abnormal in Electrocardiography. St. Louis, MO: Mosby; 1961.
15. Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas SHL. QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet. 2000;355:1048-1052.
16. Committee for Proprietary Medicinal Products. Points to Consider: The Assessment of the Potential for QT Interval Prolongation by Non-cardiovascular Medicinal Products. London, UK: European Agency for Evaluation of Medicinal Products; December 17, 1997.
17. Moss AJ, Robinson JL. The long-QT syndrome: genetic considerations. Trends Cardiovasc Med. 1992;2:81-83.
18. Reardon M, Malik M. QT interval change with age in an overly healthy older population. Clin Cordial. 1996;19:949-952.