Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds

Biochemical and Biophysical Research Communications

Volumn 421, Issue 1, 2012, Pages 15-19

  Nagai, Wataru ^a   Okita, Naoyuki ^a   Matsumoto, Hiroshi ^a   Okado, Hitoshi ^a   Oku, Misako ^a   Higami, Yoshikazu ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Caylin2; MDM2; Nutlin3a; Nutlin3b; P53; Poly(ADP ribose) polymerase1; Proteasome

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CAYLIN 2; IMIDAZOLINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NUTLIN 3; PROTEASOME; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOACCUMULATION; BIOSYNTHESIS; BRAIN INFARCTION; CELL STRAIN 3T3; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; ENZYME DEGRADATION; ENZYME INHIBITION; FIBROBLAST; GENE EXPRESSION REGULATION; HEART INFARCTION; MOUSE; NONHUMAN; ORGAN TRANSPLANTATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN INDUCTION; REPERFUSION INJURY; STEREOCHEMISTRY; TRANSACTIVATION;

3T3-L1 CELLS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOWN-REGULATION; IMIDAZOLES; MICE; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84860345867     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.091     Document Type: Article

References (20)

1. Masutani M., Nakagama H., Sugimura T. Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. Cell. Mol. Life Sci. 2005, 62:769-783.
2. Miwa M., Masutani M. PolyADP-ribosylation and cancer. Cancer Sci. 2007, 98:1528-1535.
3. Eltzschig H.K., Eckle T. Ischemia and reperfusion - from mechanism to translation. Nat. Med. 2011, 17:1391-1401.
4. van Wijk S.J., Hageman G.J. Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Radic. Biol. Med. 2005, 39:81-90.
5. Pacher P., Szabo C. Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease. Am. J. Pathol. 2008, 173:2-13.
6. Ferraris D.V. Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors, from concept to clinic. J. Med. Chem. 2010, 53:4561-4584.
7. Matsushima S., Okita N., Oku M., Nagai W., Kobayashi M., Higami Y. An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts. Biochem. Biophys. Res. Commun. 2011, 407:557-561.
8. Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., Kong N., Kammlott U., Lukacs C., Klein C., Fotouhi N., Liu E.A. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004, 303:844-848.
9. Sablina A.A., Budanov A.V., Ilyinskaya G.V., Agapova L.S., Kravchenko J.E., Chumakov P.M. The antioxidant function of the p53 tumor suppressor. Nat. Med. 2005, 11:1306-1313.
10. Santhanam U., Ray A., Sehgal P.B. Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. USA 1991, 88:7605-7609.
11. Komarova E.A., Krivokrysenko V., Wang K., Neznanov N., Chernov M.V., Komarov P.G., Brennan M.L., Golovkina T.V., Rokhlin O.W., Kuprash D.V., Nedospasov S.A., Hazen S.L., Feinstein E., Gudkov A.V. p53 is a suppressor of inflammatory response in mice. FASEB J. 2005, 19:1030-1032.
12. Wang Z., Jonca M., Lambros T., Ferguson S., Goodnow R. Exploration of liquid and supercritical fluid chromatographic chiral separation and purification of Nutlin-3 - a small molecule antagonist of MDM2. J. Pharm. Biomed. Anal. 2007, 45:720-729.
13. Cayman Chemical, . http://www.caymanchem.com/app/template/Product.vm/catalog/10009816.
14. Cayman Chemical, . http://www.caymanchem.com/app/template/Product.vm/catalog/10005002.
15. Kaufmann S.H., Desnoyers S., Ottaviano Y., Davidson N.E., Poirier G.G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 1993, 53:3976-3985.
16. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371:346-347.
17. Pop C., Salvesen G.S. Human caspases: activation, specificity, and regulation. J. Biol. Chem. 2009, 284:21777-21781.
18. Huang B., Deo D., Xia M., Vassilev L.T. Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells. Mol. Cancer Res. 2009, 7:1497-1509.
19. Chang W.J., Alvarez-Gonzalez R. The sequence-specific DNA binding of NF-kappa B is reversibly regulated by the automodification reaction of poly(ADP-ribose) polymerase 1. J. Biol. Chem. 2001, 276:47664-47670.
20. Kawaguchi M., Takahashi M., Hata T., Kashima Y., Usui F., Morimoto H., Izawa A., Takahashi Y., Masumoto J., Koyama J., Hongo M., Noda T., Nakayama J., Sagara J., Taniguchi S., Ikeda U. Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury. Circulation 2011, 123:594-604.