The gynecologist has a unique role in providing oncofertility care to young cancer patients

US Obstetrics and Gynecology

Volumn 6, Issue 1, 2011, Pages 24-34

  Duncan, Francesca E ^a   Jozefik, Jennifer K ^a   Kim, Alison M ^a   Hirshfeld Cytron, Jennifer ^a   Woodruff, Teresa K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Adolescent; Cancer; Fertility preservation; Gynecologist; Oncofertility; Young adult

Indexed keywords

EID: 84860344529     PISSN: 17546168     EISSN: 17546176     Source Type: Journal    
DOI: None     Document Type: Article

References (128)

1. NCI, A Snapshot of Adolescent and Young Adult Cancers, 2009. Available at: www.cancer.gov/aboutnci/servingpeople/aya-snapshot.pdf
2. Couzin J, Oncology. In their prime, and dying of cancer, Science, 2007;317:1160-62.
3. Zebrack B, Hamilton R, Smith AW, Psychosocial outcomes and service use among young adults with cancer, Semin Oncol, 2009;36:468-77
4. Freyer DR, Transition of care for young adult survivors of childhood and adolescent cancer: rationale and approaches, J Clin Oncol, 2010;28(32):4810-18
5. Dohle GR, Male infertility in cancer patients: Review of the literature, Int J Urol, 2010;17:327-31
6. Jeruss JS, Woodruff TK, Preservation of fertility in patients with cancer, N Engl J Med, 2009;360:902-11
7. Schmidt K, Larsen E, Andersen C, Risk for ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease, BJOG, 2010;117(2):163-74
8. Kazak AE, Derosa BW, Schwartz LA, et al., Psychological outcomes and health beliefs in adolescent and young adult survivors of childhood cancer and controls, J Clin Oncol, 2010;28:2002-7.
9. Carter J, Raviv L, Applegarth L, et al., A cross-sectional study of the psychosexual impact of cancer-related infertility in women: third-party reproductive assistance, J Cancer Surviv, 2010;4:236-46.
10. Gorman JR, Malcarne VL, Roesch SC, et al., Depressive symptoms among young breast cancer survivors: the importance of reproductive concerns, Breast Cancer Res Treat, 2010;123:477-85.
11. Carter J, Chi DS, Brown CL, et al., Cancer-related infertility in survivorship, Int J Gynecol Cancer, 2010;20:2-8.
12. Woodruff TK, The emergence of a new interdiscipline: oncofertility, Cancer Treat Res, 2007;138:3-11
13. Woodruff TK, The Oncofertility Consortium-addressing fertility in young people with cancer, Nat Rev Clin Oncol, 2010;7:466-75
14. Lee SJ, Schover LR, Partridge AH, et al., American Society of Clinical Oncology recommendations on fertility preservation in cancer patients, J Clin Oncol, 2006;24:2917-31.
15. Medicine ECotASfR, Fertility preservation and reproduction in cancer patients, Fertil Steril, 2005;83:1622-8
16. Hill LD, Erickson K, Holzman GB, et al., Practice trends in outpatient obstetrics and gynecology: findings of the Collaborative Ambulatory Research Network, 1995-2000, Obstet Gynecol Surv, 2001;56:505-16.
17. Dickerson VM, The evolution of women's primary health care in California: the role of the obstetrician/gynecologist, Prim Care Update Ob Gyns, 2001;8:116-21
18. Smith G, Toonen T, The role of the primary care physician during the active treatment phase, Prim Care, 2009;36(4):685-702
19. Rosen A, Rodriguez-Wallberg KA, Rosenzweig L, Psychosocial distress in young cancer survivors, Semin Oncol Nurs, 2009;25:268-77
20. Forman EJ, Anders CK, Behera MA, A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients, Fertil Steril, 2010;94(5):1652-6
21. Quinn GP, Vadaparampil ST, King L, et al., Impact of physicians' personal discomfort and patient prognosis on discussion of fertility preservation with young cancer patients, Patient Educ Couns, 2009;77:338-43.
22. Quinn GP, Vadaparampil ST, Lee J-H, et al., Physician referral for fertility preservation in oncology patients: a national study of practice behaviors, J Clin Oncol, 2009;27:5952-7.
23. Rosendahl M, Andersen CY, la Cour Freiesleben N, et al., Dynamics and mechanisms of chemotherapy-induced ovarian follicular depletion in women of fertile age, Fertil Steril, 2010;94:156-66.
24. Bath LE, Wallace WHB, Critchley HOD, Late effects of the treatment of childhood cancer on the female reproductive system and the potential for fertility preservation, BJOG, 2002;109:107-14
25. Critchley HO, Factors of importance for implantation and problems after treatment for childhood cancer, Med Pediatr Oncol, 1999;33:9-14
26. Ogilvy-Stuart AL, Shalet SM, Effect of radiation on the human reproductive system, Environ Health Perspect, 1993;101(Suppl. 2):109-16.
27. Oktay K, Sönmezer M, Chemotherapy and amenorrhea: risks and treatment options, Curr Opin Obstet Gynecol, 2008;20:408-15
28. Faddy MJ, Gosden RG, Gougeon A, et al., Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause, Hum Reprod, 1992;7:1342-6.
29. Wallace WHB, Thomson AB, Kelsey TW, The radiosensitivity of the human oocyte, Hum Reprod, 2003;18:117-21
30. Wallace WHB, Thomson AB, Saran F, Kelsey TW, Predicting age of ovarian failure after radiation to a field that includes the ovaries, Int J Radiat Oncol Biol Phys, 2005;62:738-44
31. Meirow D, Nugent D, The effects of radiotherapy and chemotherapy on female reproduction, Hum Reprod Update, 2001;7:535-43
32. Oktem O, Oktay K, Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal function, Cancer, 2007;110:2222-9
33. Agha A, Sherlock M, Brennan S, et al., Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults, J Clin Endocrinol Metab, 2005;90:6355-60.
34. Constine LS, Woolf PD, Cann D, et al., Hypothalamic-pituitary dysfunction after radiation for brain tumors, N Engl J Med, 1993;328:87-94.
35. Rose SR, Schreiber RE, Kearney NS, et al., Hypothalamic dysfunction after chemotherapy, J Pediatr Endocrinol Metab, 2004;17:55-66.
36. Green DM, Hall B, Zevon MA, Pregnancy outcome after treatment for acute lymphoblastic leukemia during childhood or adolescence, Cancer, 1989;64:2335-9
37. Critchley HOD, Bath LE, Wallace WHB, Radiation damage to the uterus - review of the effects of treatment of childhood cancer, Hum Fertil (Camb), 2002;5:61-6
38. Critchley HOD, Wallace WHB, Impact of cancer treatment on uterine function, J Natl Cancer Inst Monographs, 2005;34:64-8
39. Wo J, Viswanathan A, Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients, Int J Radiat Oncol, 2009;73(5):1304-12
40. Norwitz ER, Stern HM, Grier H, Lee-Parritz A, Placenta percreta and uterine rupture associated with prior whole body radiation therapy, Obstet Gynecol, 2001;98(5 Pt 2):929-31
41. Yang D, Hladnik L, Treatment of acute promyelocytic leukemia during pregnancy, Pharmacotherapy, 2009;29:709-24
42. Vinatier E, Merlot B, Poncelet E, et al., Breast cancer during pregnancy, Eur J Obstet Gynecol Reprod Biol, 2009;147:9-14.
43. Sadovsky R, Basson R, Krychman M, et al., Cancer and sexual problems, J Sex Med, 2010;7(1 Pt 2):349-73.
44. Fobair P, Spiegel D, Concerns about sexuality after breast cancer, Cancer J, 2009;15:19-26
45. Carter J, Rowland K, Chi D, et al., Gynecologic cancer treatment and the impact of cancer-related infertility, Gynecol Oncol, 2005;97:90-95.
46. Ata B, Chian R-C, Tan SL, Cryopreservation of oocytes and embryos for fertility preservation for female cancer patients, Best Pract Res Clin Obstet Gynaecol, 2010;24:101-12
47. Loutradi KE, Kolibianakis EM, Venetis CA, et al., Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis, Fertil Steril, 2008;90:186-93.
48. ICMART, International Committee Monitoring ART: Presentation of preliminary data for 2004, 24th Annual Meeting of the ESHRE, Barcelona, Spain, 2008
49. Wennerholm U, Soderstrom-Anttila V, Bergh C, Children born after cryopreservation of embryos or oocytes: a systematic review of outcome data, Hum Reprod, 2009;24(9):2158-72
50. Oktay K, Buyuk E, Davis O, et al., Fertility preservation in breast cancer patients: IVF and embryo cryopreservation after ovarian stimulation with tamoxifen, Hum Reprod, 2003;18:90-95.
51. Hulvat MC, Jeruss JS, Maintaining fertility in young women with breast cancer, Curr Treat Options Oncol, 2009;10:308-17
52. Crockin SL, Legal issues related to parenthood after cancer, J Natl Cancer Inst Monographs, 2005;34:111-13
53. Dolin G, Roberts DE, Rodriguez LM, Woodruff TK, Medical hope, legal pitfalls: potential legal issues in the emerging field of oncofertility, Cancer Treat Res, 2010;156:111-34
54. Campo-Engelstein L, Consistency in insurance coverage for iatrogenic conditions resulting from cancer treatment including fertility preservation, J Clin Oncol, 2010;28:1284-6
55. Grifo JA, Noyes N, Delivery rate using cryopreserved oocytes is comparable to conventional in vitro fertilization using fresh oocytes: potential fertility preservation for female cancer patients, Fertil Steril, 2010;93:391-6
56. Noyes N, Boldt J, Nagy ZP, Oocyte cryopreservation: is it time to remove its experimental label?, J Assist Reprod Genet, 2010;27:69-74
57. Moragianni VA, Penzias AS, Cumulative live-birth rates after assisted reproductive technology, Curr Opin Obstet Gynecol, 2010;22:189-92
58. Hunt PA, Hassold TJ, Human female meiosis: what makes a good egg go bad?, Trends Genet, 2008;24:86-93
59. Broekmans FJ, Kwee J, Hendriks DJ, et al., A systematic review of tests predicting ovarian reserve and IVF outcome, Hum Reprod Update, 2006;12:685-718.
60. Donnez J, Jadoul P, Squifflet J, et al., Ovarian tissue cryopreservation and transplantation in cancer patients, Best Pract Res Clin Obstet Gynaecol, 2010;24:87-100.
61. von Wolff M, Donnez J, Hovatta O, et al., Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy-a technique in its infancy but already successful in fertility preservation, Eur J Cancer, 2009;45:1547-53.
62. Sonmezer M, Oktay K, Orthotopic and heterotopic ovarian tissue transplantation, Best Pract Res Clin Obstet Gynaecol, 2010;24:113-26
63. Roux C, Amiot C, Agnani G, et al., Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation, Fertil Steril, 2010;93:2413.e2415-19.
64. Donnez J, Dolmans MM, Demylle D, et al., Livebirth after orthotopic transplantation of cryopreserved ovarian tissue, Lancet, 2004;364:1405-10.
65. Meirow D, Levron J, Eldar-Geva T, et al., Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy, N Engl J Med, 2005;353:318-21.
66. Demeestere I, Simon P, Emiliani S, et al., Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin's disease, Oncologist, 2007;12:1437-42.
67. Andersen CY, Rosendahl M, Byskov AG, et al., Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue, Hum Reprod, 2008;23:2266-72.
68. Silber SJ, Grudzinskas G, Gosden RG, Successful pregnancy after microsurgical transplantation of an intact ovary, N Engl J Med, 2008;359:2617-18
69. Meirow D, Hardan I, Dor J, et al., Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients, Hum Reprod, 2008;23:1007-13.
70. Xu M, Kreeger PK, Shea LD, Woodruff TK, Tissue-engineered follicles produce live, fertile offspring, Tissue Eng, 2006;12:2739-46
71. Xu M, Barrett SL, West-Farrell E, et al., In vitro grown human ovarian follicles from cancer patients support oocyte growth, Hum Reprod, 2009;24:2531-40.
72. Xu M, Banc A, Woodruff TK, Shea LD, Secondary follicle growth and oocyte maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles, Biotechnol Bioeng, 2009;103:378-86
73. Xu M, West-Farrell ER, Stouffer RL, et al., Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles, Biol Reprod, 2009;81:587-94.
74. Schieve LA, Rasmussen SA, Buck GM, et al., Are children born after assisted reproductive technology at increased risk for adverse health outcomes?, Obstet Gynecol, 2004;103:1154-63.
75. Amor DJ, Halliday J, A review of known imprinting syndromes and their association with assisted reproduction technologies, Hum Reprod, 2008;23:2826-34
76. Schover LR, Motivation for parenthood after cancer: a review, J Natl Cancer Inst Monogr, 2005;34:2-5
77. Garber JE, Offit K, Hereditary cancer predisposition syndromes, J Clin Oncol, 2005;23:276-92
78. Simpson JL, Preimplantation genetic diagnosis at 20 years, Prenat Diagn, 2010;30:682-95
79. Spits C, De Rycke M, Van Ranst N, et al., Preimplantation genetic diagnosis for cancer predisposition syndromes, Prenat Diagn, 2007;27(5):447-56.
80. Mueller BA, Chow EJ, Kamineni A, et al., Pregnancy outcomes in female childhood and adolescent cancer survivors: a linked cancer-birth registry analysis, Arch Pediatr Adolesc Med, 2009;163:879-86.
81. Maheshwari A, Fowler P, Bhattacharya S, Assessment of ovarian reserve-should we perform tests of ovarian reserve routinely?, Hum Reprod, 2006;21:2729-35
82. Jayaprakasan K, Campbell B, Hopkisson J, et al., A prospective, comparative analysis of anti-Müllerian hormone, inhibin-B, and three-dimensional ultrasound determinants of ovarian reserve in the prediction of poor response to controlled ovarian stimulation, Fertil Steril, 2010;93:855-64.
83. Domingues TS, Rocha AM, Serafini PC, Tests for ovarian reserve: reliability and utility, Curr Opin Obstet Gynecol, 2010;22:271-6
84. La Marca A, Volpe A, Anti-Müllerian hormone (AMH) in female reproduction: is measurement of circulating AMH a useful tool?, Clin Endocrinol (Oxf), 2006;64:603-10
85. Kwee J, Schats R, McDonnell J, et al., Evaluation of anti-Müllerian hormone as a test for the prediction of ovarian reserve, Fertil Steril, 2008;90:737-43.
86. de Vet A, Laven JS, de Jong FH, et al., Antimullerian hormone serum levels: a putative marker for ovarian aging, Fertil Steril, 2002;77:357-62.
87. van Disseldorp J, Faddy MJ, Themmen AP, et al., Relationship of serum antimullerian hormone concentration to age at menopause, J Clin Endocrinol Metab, 2008;93:2129-34.
88. van Rooij IA, Tonkelaar I, Broekmans FJ, et al., Anti-mullerian hormone is a promising predictor for the occurrence of the menopausal transition, Menopause, 2004;11:601-6.
89. Haadsma ML, Bukman A, Groen H, et al., The number of small antral follicles (2-6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population, Hum Reprod, 2007;22:1925-31.
90. Fanchin R, Schonauer LM, Righini C, et al., Serum anti-Mullerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3, Hum Reprod, 2003;18:323-7.
91. Partridge AH, Ruddy KJ, Gelber S, et al., Ovarian reserve in women who remain premenopausal after chemotherapy for early stage breast cancer, Fertil Steril, 2010;94:638-44.
92. Hansen KR, Hodnett GM, Knowlton N, Craig LB, Correlation of ovarian reserve tests with histologically determined primordial follicle number, Fertil Steril, 2011;95(1):170-5
93. Lie Fong S, Lugtenburg PJ, Schipper I, et al., Anti-müllerian hormone as a marker of ovarian function in women after chemotherapy and radiotherapy for haematological malignancies, Hum Reprod, 2008;23:674-8.
94. Lie Fong S, Laven JSE, Hakvoort-Cammel FGAJ, et al., Assessment of ovarian reserve in adult childhood cancer survivors using anti-Müllerian hormone, Hum Reprod, 2009;24:982-90.
95. Singh K, Muttukrishna S, Stein R, Predictors of ovarian reserve in young women with breast cancer, Br J Cancer, 2007;96(12):1808-16
96. Yu B, Douglas N, Ferin MJ, et al., Changes in markers of ovarian reserve and endocrine function in young women with breast cancer undergoing adjuvant chemotherapy, Cancer, 2010;116:2099-2105.
97. Johnston RJ, Wallace WHB, Normal ovarian function and assessment of ovarian reserve in the survivor of childhood cancer, Pediatr Blood Cancer, 2009;53:296-302
98. Zebrack B, Information and service needs for young adult cancer survivors, Support Care Cancer, 2009;17:349-57
99. Zebrack B, Information and service needs for young adult cancer patients, Support Care Cancer, 2008;16:1353-60
100. Xyrichis A, Ream E, Teamwork: a concept analysis, J Adv Nursing, 2008 Jan;61(2):232-41
101. Gardino SL, Jeruss JS, Woodruff TK, Using decision trees to enhance interdisciplinary team work: the case of oncofertility, J Assist Reprod Genet, 2010;27:227-31
102. Terenziani M, Piva L, Meazza C, et al., Oophoropexy: a relevant role in preservation of ovarian function after pelvic irradiation, Fertil Steril, 2009;91:935.e915-36.
103. Williams RS, Littell RD, Mendenhall NP, Laparoscopic oophoropexy and ovarian function in the treatment of Hodgkin disease, Cancer, 1999;86:2138-42
104. Bardo DM, Black M, Schenk K, Zaritzky MF, Location of the ovaries in girls from newborn to 18 years of age: reconsidering ovarian shielding, Pediatr Radiol, 2009;39:253-9
105. Cao YX, Chian RC, Fertility preservation with immature and in vitro matured oocytes, Semin Reprod Med, 2009;27:456-64
106. Chian RC, Buckett WM, Abdul Jalil AK, et al., Natural-cycle in vitro fertilization combined with in vitro maturation of immature oocytes is a potential approach in infertility treatment, Fertil Steril, 2004;82:1675-8.
107. Huang JY, Tulandi T, Holzer H, et al., Combining ovarian tissue cryobanking with retrieval of immature oocytes followed by in vitro maturation and vitrification: an additional strategy of fertility preservation, Fertil Steril, 2008;89:567-72.
108. Smitz J, Dolmans MM, Donnez J, et al., Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation, Hum Reprod Update, 2010;16:395-414.
109. Oktay K, Sonmezer M, Oktem O, et al., Absence of conclusive evidence for the safety and efficacy of gonadotropin-releasing hormone analogue treatment in protecting against chemotherapy-induced gonadal injury, Oncologist, 2007;12:1055-66.
110. Amorim CA, Van Langendonckt A, David A, et al., Survival of human pre-antral follicles after cryopreservation of ovarian tissue, follicular isolation and in vitro culture in a calcium alginate matrix, Hum Reprod, 2009;24:92-9.
111. Barrett SL, Shea LD, Woodruff TK, Noninvasive index of cryorecovery and growth potential for human follicles in vitro, Biol Reprod, 2010;82:1180-89
112. Dolmans MM, Martinez-Madrid B, Gadisseux E, et al., Shortterm transplantation of isolated human ovarian follicles and cortical tissue into nude mice, Reproduction, 2007;134:253-62.
113. Dolmans M-M, Yuan WY, Camboni A, et al., Development of antral follicles after xenografting of isolated small human preantral follicles, Reprod Biomed Online, 2008;16:705-11.
114. Dath C, Van Eyck AS, Dolmans MM, et al., Xenotransplantation of human ovarian tissue to nude mice: comparison between four grafting sites, Hum Reprod, 2010;25:1734-43.
115. Kim SS, Kang HG, Kim NH, et al., Assessment of the integrity of human oocytes retrieved from cryopreserved ovarian tissue after xenotransplantation, Hum Reprod, 2005;20:2502-8.
116. Kim SS, Soules MR, Battaglia DE, Follicular development, ovulation, and corpus luteum formation in cryopreserved human ovarian tissue after xenotransplantation, Fertil Steril, 2002;78:77-82
117. Ahn RW, Chen F, Chen H, et al., A novel nanoparticulate formulation of arsenic trioxide with enhanced therapeutic efficacy in a murine model of breast cancer, Clin Cancer Res, 2010;16:3607-17.
118. Chen H, Pazicni S, Krett NL, et al., Coencapsulation of arsenic- and platinum-based drugs for targeted cancer treatment, Angew Chem Int Ed Engl, 2009;48:9295-9.
119. Gardino SL, Russell AE, Woodruff TK, Adoption after cancer: adoption agency attitudes and perspectives on the potential to parent post-cancer, Cancer Treat Res, 2010;156:153-70
120. Sills ES, Alper MM, Walsh APH, Ovarian reserve screening in infertility: practical applications and theoretical directions for research, Eur J Obstet Gynecol Reprod Biol, 2009;146:30-36
121. Coccia ME, Rizzello F, Ovarian reserve, Ann N Y Acad Sci, 2008;1127:27-30
122. Seifer DB, Scott RT, Jr, Bergh PA, et al. Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone, Fertil Steril, 1999;72:63-5.
123. Hendriks DJ, Kwee J, Mol BWJ, et al., Ultrasonography as a tool for the prediction of outcome in IVF patients: a comparative meta-analysis of ovarian volume and antral follicle count, Fertil Steril, 2007;87:764-75.
124. Muttukrishna S, McGarrigle H, Wakim R, et al., Antral follicle count, anti-mullerian hormone and inhibin B: predictors of ovarian response in assisted reproductive technology?, BJOG, 2005;112:1384-90.
125. Bancsi LFJMM, Broekmans FJM, Eijkemans MJC, et al., Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve, Fertil Steril, 2002;77:328-36.
126. Syrop CH, Willhoite A, Van Voorhis BJ, Ovarian volume: a novel outcome predictor for assisted reproduction, Fertil Steril, 1995;64:1167-71
127. Hendriks DJ, Broekmans FJM, Bancsi LFJMM, et al., Repeated clomiphene citrate challenge testing in the prediction of outcome in IVF: a comparison with basal markers for ovarian reserve, Hum Reprod, 2005;20:163-9.
128. Ragni G, Chiaffarino F, Scarduelli C, et al., The clomiphene citrate challenge test (CCCT) in women with elevated basal FSH: biological significance and predictive value, Eur J Obstet Gynecol Reprod Biol, 2008;141:44-8.