Prognostic significance of the lymph node ratio regarding recurrence and survival in rectal cancer patients treated with postoperative chemoradiotherapy

Gut and Liver

Volumn 6, Issue 2, 2012, Pages 203-209

  Kim, Ji Yoon ^a   Chung, Su Mi ^a   Choi, Byung Ock ^a   Lee, In Kyu ^a   An, Chang Hyeok ^a   Won, Jong Man ^a   Ryu, Mi Ryeong ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Combined modality therapy; Lymph nodes; Rectal neoplasms

Indexed keywords

CAPECITABINE; FLUOROURACIL; FOLINIC ACID;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; MULTIVARIATE ANALYSIS; POSTOPERATIVE CARE; PREDICTION; PROGNOSIS; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM ANTERIOR RESECTION; RECTUM CANCER; TREATMENT OUTCOME; TUMOR VOLUME;

EID: 84860340635     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2012.6.2.203     Document Type: Article

References (21)

1. Jung KW, Park S, Kong HJ, et al. Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2008. Cancer Res Treat 2011;43:1-11.
2. Kwon JH, Choi MG, Lee SW, et al. Trends of gastrointestinal diseases at a single institution in Korea over the past two decades. Gut Liver 2009;3:252-258.
3. Enker WE, Thaler HT, Cranor ML, Polyak T. Total mesorectal excision in the operative treatment of carcinoma of the rectum. J Am Coll Surg 1995;181:335-346.
4. Sebag-Montefiore D, Glynne-Jones R, Falk S, Meadows HM, Maughan T. A phase I/II study of oxaliplatin when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: A Colorectal Clinical Oncology Group (CCOG) study. Br J Cancer 2005;93:993-998. (Pubitemid 41548392)
5. Pfeiffer P. High-dose radiotherapy and concurrent UFT plus lleucovorin in locally advanced rectal cancer: A phase I trial. Acta Oncol 2005;44:224-229. (Pubitemid 40904124)
6. Vinh-Hung V, Verkooijen HM, Fioretta G, et al. Lymph node ratio as an alternative to pN staging in node-positive breast cancer. J Clin Oncol 2009;27:1062-1068.
7. Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, Wisnivesky JP. Prognostic significance of the number of lymph node metastases in esophageal cancer. J Am Coll Surg 2008;206:239-246.
8. Chan JK, Kapp DS, Cheung MK, et al. The impact of the absolute number and ratio of positive lymph nodes on survival of endometrioid uterine cancer patients. Br J Cancer 2007;97:605-611. (Pubitemid 47339879)
9. De Ridder M, Vinh-Hung V, Van Nieuwenhove Y, Hoorens A, Sermeus A, Storme G. Prognostic value of the lymph node ratio in node positive colon cancer. Gut 2006;55:1681. (Pubitemid 44629243)
10. Greene FL, Page DL, Fleming ID, et al. AJCC Cancer Staging Manual. 6th ed. New York: Springer-Verlag, 2002:113-119.
11. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. AJCC Cancer Staging Manual. 7th ed. New York: Springer, 2009:143-159.
12. Mekenkamp LJ, van Krieken JH, Marijnen CA, van de Velde CJ, Nagtegaal ID; Pathology Review Committee and the Co-operative Clinical Investigators. Lymph node retrieval in rectal cancer is dependent on many factors: The role of the tumor, the patient, the surgeon, the radiotherapist, and the pathologist. Am J Surg Pathol 2009;33:1547-1553.
13. Thorn CC, Woodcock NP, Scott N, Verbeke C, Scott SB, Ambrose NS. What factors affect lymph node yield in surgery for rectal cancer? Colorectal Dis 2004;6:356-361. (Pubitemid 39236535)
14. Hermanek P, Giedl J, Dworak O. Two programmes for examination of regional lymph nodes in colorectal carcinoma with regard to the new pN classification. Pathol Res Pract 1989;185:867-873. (Pubitemid 20070799)
15. Inoue K, Nakane Y, Iiyama H, et al. The superiority of ratiobased lymph node staging in gastric carcinoma. Ann Surg Oncol 2002;9:27-34. (Pubitemid 34262894)
16. Rosenberg R, Friederichs J, Schuster T, et al. Prognosis of patients with colorectal cancer is associated with lymph node ratio: A single-center analysis of 3,026 patients over a 25-year time period. Ann Surg 2008;248:968-978.
17. Rosenberg R, Engel J, Bruns C, et al. The prognostic value of lymph node ratio in a population-based collective of colorectal cancer patients. Ann Surg 2010;251:1070-1078.
18. Kim YS, Kim JH, Yoon SM, et al. lymph node ratio as a prognostic factor in patients with stage III rectal cancer treated with total mesorectal excision followed by chemoradiotherapy. Int J Radiat Oncol Biol Phys 2009;74:796-802.
19. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351:1731-1740.
20. Peschaud F, Benoist S, Julié C, et al. The ratio of metastatic to examined lymph nodes is a powerful independent prognostic factor in rectal cancer. Ann Surg 2008;248:1067-1073.
21. Oh TY, Moon SM, Shin US, Lee HR, Park SH. Impact on prognosis of lymph node micrometastasis and isolated tumor cells in stage II colorectal cancer. J Korean Soc Coloproctol 2011;27:71-77.