Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety

Biopolymers

Volumn 98, Issue 1, 2012, Pages 1-10

  Leurs, Ulrike ^a   Mezo, Gabor ^b   Orbán, Erika ^b   Ohlschläger, Peter ^a   Marquardt, Andreas ^a   Manea, Marilena ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Cytostatic effect; Drug design; Gonadotropin releasing hormone III; Multifunctional anticancer drug peptide bioconjugates; Targeted cancer chemotherapy

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELLS; CHEMOTHERAPY; DESIGN; DISEASES; DRUG DELIVERY;

BIOCONJUGATES; CANCER CHEMOTHERAPY; CYTOSTATIC; DRUG DESIGN; GONADOTROPIN-RELEASING HORMONE-III;

BIOMOLECULES;

DAUNORUBICIN; DAUNORUBICIN DERIVATIVE; GONADORELIN DERIVATIVE; GONADORELIN RECEPTOR; LYSINE; ANTINEOPLASTIC AGENT;

ARTICLE; CANCER CELL LINE; CONJUGATE; CONTROLLED STUDY; CYTOSTASIS; DRUG CONJUGATION; DRUG DEGRADATION; DRUG DESIGN; DRUG EFFICACY; DRUG STABILITY; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER HOMOGENATE; LIVER LYSOSOME; NONHUMAN; RAT; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; NEOPLASM;

RATTUS;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; DAUNORUBICIN; HUMANS; NEOPLASMS;

EID: 84860338337     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21640     Document Type: Article

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