No Association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study

BMC Medical Genetics

Volumn 13, Issue , 2012, Pages

  Lähteelä, Kati ^a   Kunnas, Tarja ^a   Lyytikäinen, Leo Pekka ^b   Mononen, Nina ^b   Taittonen, Leena ^c   Laitinen, Tomi ^d   Kettunen, Johannes ^e   Juonala, Markus ^f   Hutri Kähönen, Nina ^b   Kähönen, Mika ^b   Viikari, Jorma S ^f   Raitakari, Olli T ^g   Lehtimäki, Terho ^b   Nikkari, Seppo T ^a  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

^f UNIVERSITY OF TURKU   (Finland)

^g UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; BIOLOGICAL MARKER; PTGS2 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ALLELE; ARTERIAL WALL THICKNESS; ARTERY COMPLIANCE; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR RISK; CAROTID ARTERY; CHILD; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; CAROTID ARTERY DISEASE; FINLAND; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; PHYSIOLOGY;

ADOLESCENT; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CHILD; CHILD, PRESCHOOL; CYCLOOXYGENASE 2; FEMALE; FINLAND; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84860324516     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-13-32     Document Type: Article

References (29)

1. Libby P: Molecular bases of the acute coronary syndromes. Circulation 1995, 91:2844-2850.
2. DeWitt D, Smith WL: Yes, but do they still get headaches?. Cell 1995, 83:345-348.
3. Cipollone F, Toniato E, Martinotti S, Mezzetti A: Genetic and molecular determinants of atherosclerotic plaque instability. Curr Vasc Pharmacol 2010, 8:545-552.
4. Schönbeck U, Sukhova GK, Graber P, Coulter S, Libby P: Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions. Am J Pathol 1999, 155:1281-1291.
5. Baker CS, Hall RJ, Evans TJ, Pomerance A, Maclouf J, Creminon C, Yacoub MH, Polak JM: Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages. Arterioscler Thromb Vasc Biol 1999, 19:646-655.
6. Linton MF, Fazio S: Cyclooxygenase-2 and inflammation in atherosclerosis. Curr Opin Pharmacol 2004, 4:116-123.
7. Huuskonen KH, Kunnas TA, Tanner MM, Mikkelsson J, Ilveskoski E, Karhunen PJ, Nikkari ST: COX-2 gene promoter polymorphism and coronary artery disease in middle-aged men: the Helsinki sudden death study. Mediators Inflamm 2008 , 2008:289453.
8. Vogel U, Segel S, Dethlefsen C, Tjønneland A, Saber AT, Wallin H, Jensen MK, Schmidt EB, Andersen PS, Overvad K: Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome. Atherosclerosis 2010, 209:155-162.
9. Cipollone F, Toniato E, Martinotti S, Fazia M, Iezzi A, Cuccurullo C, Pini B, Ursi S, Vitullo G, Averna M, Arca M, Montali A, Campagna F, Ucchino S, Spigonardo F, Taddei S, Virdis A, Ciabattoni G, Notarbartolo A, Cuccurullo F, Mezzetti A: A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. JAMA 2004, 291:2221-2228.
10. Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA: Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998, 338:1650-1656.
11. Chan ES, Zhang H, Fernandez P, Edelman SD, Pillinger MH, Ragolia L, Palaia T, Carsons S, Reiss AB: Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk. Arthritis Res Ther 2007, 9:R4.
12. Papafili A, Hill MR, Brull DJ, McAnulty RJ, Marshall RP, Humphries SE, Laurent GJ: Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol 2002, 22:1631-1636.
13. Orbe J, Beloqui O, Rodriguez JA, Belzunce MS, Roncal C, Paramo JA: Protective effect of the G-765 C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors. Clin Chim Acta 2006, 368:138-143.
14. Cok SJ, Morrison AR: The 3-Untranslated region of murine cyclooxygenase-2 contains multiple regulatory elements that alter message stability and translational efficiency. J Biol Chem 2001, 276:23179-23185.
15. Akerblom HK, Viikari J, Uhari M, Räsänen L, Byckling T, Louhivuori K, Pesonen E, Suoninen P, Pietikäinen M, Lähde PL, et al: Atherosclerosis precursors in Finnish children and adolescents. I. General description of the crosssectional study of 1980, and an account of the children's and families' state of health. Acta Paediatr Scand Suppl 1985, 318:49-63.
16. Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko N, Järvisalo MJ, Uhari M, Jokinen E, Rönnemaa T, Åkerblom HK, Viikari JS: Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 2003, 290:2277-2283.
17. Raitakari OT, Juonala M, Rönnemaa T, Keltinkangas-Järvinen L, Räsänen L, Pietikäinen M, Hutri-Kähönen N, Taittonen L, Jokinen E, Marniemi J, Jula A, Telama R, Kähönen M, Lehtimäki T, Åkerblom HK, Viikari JS: Cohort profile: the Cardiovascular Risk in Young Finns Study. Int J Epidemiol 2008, 37:1220-1226.
18. Juonala M, Viikari JS, Hutri-Kähönen N, Pietikäinen M, Jokinen E, Taittonen L, Marniemi J, Rönnemaa T, Raitakari OT: The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east-west difference. J Intern Med 2004, 255:457-468.
19. Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JS, Raitakari OT: Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 2005, 112:1486-1493.
20. Smith EN, Chen W, Kähönen M, Kettunen J, Lehtimäki T, Peltonen L, Raitakari OT, Salem RM, Schork NJ, Shaw M, Srinivasan SR, Topol EJ, Viikari JS, Berenson GS, Murray SS: Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. PLoS Genet 2010, 6:e1001094.
21. Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR: MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 2010, 34:816-834.
22. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC: PLINK: a tool set for wholegenome association and population-based linkage analyses. Am J Hum Genet 2007, 81:559-575.
23. Aulchenko YS, Struchalin MV, van Duijn CM: ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics 2010, 11:134.
24. Strimmer K: A unified approach to false discovery rate estimation. BMC Bioinformatics 2008, 9:303.
25. Strimmer K: fdrtool: a versatile R package for estimating local and tail area-based false discovery rates. Bioinformatics 2008, 24:1461-1462.
26. Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM: Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 1998, 32:570-574.
27. Rudock ME, Liu Y, Ziegler JT, Allen SG, Lehtinen AB, Freedman BI, Carr JJ, Langefeld CD, Bowden DW: Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. Atherosclerosis 2009, 203:459-465.
28. Hegener HH, Diehl KA, Kurth T, Gaziano JM, Ridker PM, Zee RY: Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. J Thromb Haemost 2006, 4:1718-1722.
29. Maguire J, Thakkinstian A, Levi C, Lincz L, Bisset L, Sturm J, Scott R, Whyte S, Attia J: Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: A novel finding. J Stroke Cerebrovasc Dis 2011, 20:134-144.