High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 68, Issue 4, 2012, Pages 404-408

  Fradera, Xavier ^a   Kazemier, Bert ^a   Carswell, Emma ^a   Cooke, Andrew ^a   Oubrie, Arthur ^a   Hamilton, William ^a   Dempster, Maureen ^a   Krapp, Stephan ^b   Nagel, Susanna ^b   Jestel, Anja ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b PROTEROS BIOSTRUCTURES GMBH   (Germany)

Author keywords

Coagulation factors; Factor XIa; Inhibitors

Indexed keywords

BLOOD CLOTTING FACTOR 11A; ENZYME INHIBITOR; LIGAND;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN DOMAIN; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FACTOR XIA; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84860307159     PISSN: None     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309112009037     Document Type: Article

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