Medical management of ectopic pregnancy: A comparison of regimens

Clinical Obstetrics and Gynecology

Volumn 55, Issue 2, 2012, Pages 440-447

  Bachman, Emelia Argyropoulos ^a   Barnhart, Kurt ^b  

^a Penn Fertility Care   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Ectopic pregnancy; hCG; medical treatment; methotrexate; treatment

Indexed keywords

CHORIONIC GONADOTROPIN; FOLINIC ACID; METHOTREXATE;

ALOPECIA AREATA; CARDIOVASCULAR MALFORMATION; CHORIOCARCINOMA; CLINICAL PROTOCOL; CRANIOFACIAL MALFORMATION; DERMATITIS; DRUG CONTRAINDICATION; ECTOPIC PREGNANCY; FETUS MALFORMATION; GASTROINTESTINAL MALFORMATION; HUMAN; HYPERTELORISM; INTERMETHOD COMPARISON; INTERSTITIAL PNEUMONIA; MEDICAL DECISION MAKING; NEPHROTOXICITY; PSORIASIS; REVIEW; RISK; RUPTURE; SCOLIOSIS; SIDE EFFECT; SINGLE DRUG DOSE; SKELETON MALFORMATION; TREATMENT CONTRAINDICATION; TREATMENT INDICATION;

ABORTIFACIENT AGENTS, NONSTEROIDAL; CHORIONIC GONADOTROPIN; CLINICAL PROTOCOLS; DECISION MAKING; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; METHOTREXATE; PATIENT COMPLIANCE; PATIENT SELECTION; PREGNANCY; PREGNANCY, ECTOPIC;

EID: 84860306292     PISSN: 00099201     EISSN: 15325520     Source Type: Journal    
DOI: 10.1097/GRF.0b013e3182510a73     Document Type: Review

References (27)

1. Creanga AA, Shapiro-Mendoza CK, Bish CL, et al. Trends in ectopic pregnancy mortality in the United States: 1980-2007. Obstet Gynecol. 2011;117:837-843.
2. Barnhart K, Coutifaris C, Esposito M. The pharmacology of methotrexate. Expert Opin Pharmacother. 2001;2:409-417. (Pubitemid 32427739)
3. ACOG Practice Bulletin No. 94: Medical management of ectopic pregnancy. Obstet Gynecol. 2008;111:1479-1485.
4. Tanaka T, Hayashi H, Kutsuzawa T, et al. Treatment of interstitial ectopic pregnancy with methotrexate: Report of a successful case. Fertil Steril. 1982;37: 851-852. (Pubitemid 12078026)
5. Rodi IA, SauerMV, GorrillMJ, et al. The medical treatment of unruptured ectopic pregnancy with methotrexate and citrovorum rescue: Preliminary experience. Fertil Steril. 1986;46:811-813. (Pubitemid 17187651)
6. Stovall TG, Ling FW, Buster JE. Outpatient chemotherapy of unruptured ectopic pregnancy. Fertil Steril. 1989;51: 435-438. (Pubitemid 19083654)
7. Stovall TG, Ling FW, Gray LA, et al. Methotrexate treatment of unruptured ectopic pregnancy: A report of 100 cases. Obstet Gynecol. 1991;77:749-753.
8. Barnhart KT, Gosman G, Ashby R, et al. The medical management of ectopic pregnancy: A meta-analysis comparing ''single dose'' and ''multidose'' regimens. Obstet Gynecol. 2003;101:778-784. (Pubitemid 36390071)
9. Stovall TG, Ling FW, Gray LA. Singledose methotrexate for treatment of ectopic pregnancy. Obstet Gynecol. 1991; 77:754-757.
10. Stovall TG, Ling FW. Single-dose methotrexate: An expanded clinical trial. Am J Obstet Gynecol. 1993;168:1759-1762 discussion 62-65.
11. Barnhart K, Hummel AC, Sammel MD, et al. Use of ''2-dose'' regimen of methotrexate to treat ectopic pregnancy. Fertil Steril. 2007;87:250-256. (Pubitemid 46176932)
12. Lipscomb GH, McCord ML, Stovall TG, et al. Predictors of success of methotrexate treatment inwomen with tubal ectopic pregnancies. N Engl J Med. 1999;341: 1974-1978. (Pubitemid 30010405)
13. Menon S, Colins J, Barnhart KT. Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: A systematic review. Fertil Steril. 2007;87:481-484. (Pubitemid 46385986)
14. Mol F, Mol BW, AnkumWM, et al. Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: A systematic review and meta-analysis. Hum Reprod Update. 2008;14:309-319. (Pubitemid 351858971)
15. Jaspan D, Giraldo-Isaza M, Dandolu V, et al. Compliance with methotrexate therapy for presumed ectopic pregnancy in an inner-city population. Fertil Steril. 2010; 94:1122-1124.
16. Butts SF, Gibson E, Sammel MD, et al. Socioeconomic status, and response to methotrexate treatment of ectopic pregnancy in an urban population. Fertil Steril. 2010;94:2789-2792.
17. Dudley PS, Heard MJ, Sangi-Haghpeykar H, et al. Characterizing ectopic pregnancies that rupture despite treatment with methotrexate. Fertil Steril. 2004;82: 1374-1378. (Pubitemid 39469464)
18. Barnhart KT, Fay CA, Suescum M, et al. Clinical factors affecting the accuracy of ultrasonography in symptomatic first-T rimester pregnancy. Obstet Gynecol. 2011; 117:299-306.
19. Barnhart KT, Katz I, Hummel A, et al. Presumed diagnosis of ectopic pregnancy. Obstet Gynecol. 2002;100:505-510. (Pubitemid 35246137)
20. Chung K, Chandavarkar U, Opper N, et al. Reevaluating the role of dilation and curettage in the diagnosis of pregnancy of unknown location. Fertil Steril. 2011;96:659-662.
21. Shaunik A, Kulp J, Appleby DH, et al. Utility of dilation and curettage in the diagnosis of pregnancy of unknown location. AmJObstetGynecol. 2011;204:e1-e6.
22. Nguyen C, Duhl AJ, Escallon CS, et al. Multiple anomalies in a fetus exposed to low-dose methotrexate in the first trimester. Obstet Gynecol. 2002;99:599-602. (Pubitemid 34246297)
23. Addar MH. Methotrexate embryopathy in a surviving intrauterine fetus after presumed diagnosis of ectopic pregnancy: Case report. J Obstet Gynaecol Can. 2004;26:1001-1003.
24. Usta IM, Nassar AH, Yunis KA, et al. Methotrexate embryopathy after therapy for misdiagnosed ectopic pregnancy. Int J Gynaecol Obstet. 2007;99:253-255. (Pubitemid 350007592)
25. McLaren JF, Burney RO, Milki AA, et al. Effect of methotrexate exposure on subsequent fertility in women undergoing controlled ovarian stimulation. Fertil Steril. 2009;92:515-519.
26. Oriol B, Barrio A, Pacheco A, et al. Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve. Fertil Steril. 2008;90:1579-1582.
27. ASRM Practice Bulletin. Medical treatment of ectopic pregnancy. Fertil Steril. 2006;86:S96-S102.