Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): Influence of a zinc-enriched environment

Rejuvenation Research

Volumn 15, Issue 2, 2012, Pages 140-143

  Malavolta, Marco ^a   Basso, Andrea ^a   Piacenza, Francesco ^a   Giacconi, Robertina ^a   Costarelli, Laura ^a   Pierpaoli, Sara ^a   Mocchegiani, Eugenio ^a  

^a INRCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

METALLOTHIONEIN I; ZINC;

AGING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; GENE THERAPY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SURVIVAL; TRANSGENIC MOUSE;

AGING; ANIMALS; DIETARY SUPPLEMENTS; MALE; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; STOCHASTIC PROCESSES; TIME FACTORS; ZINC;

MUS; MUS MUSCULUS;

EID: 84860288746     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2011.1261     Document Type: Article

References (20)

1. Thornalley PJ, Vasák M. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim Biophys Acta 1985;827:36-44.
2. Ye B, Maret W, Vallee BL. Zinc metallothionein imported into liver mitochondria modulates respiration. Proc Natl Acad Sci USA 2001;98:2317-2322.
3. Zangger K, Oz G, Haslinger E, Kunert O, Armitage IM. Nitric oxide selectively releases metals from the aminoterminal domain of metallothioneins: Potential role at inflammatory sites. FASEB J 2001;15:1303-1305.
4. Mocchegiani E, Giacconi R, Cipriano C, Malavolta M. NK and NKT cells in aging and longevity: Role of zinc and metallothioneins. J Clin Immunol 2009;29:416-425.
5. Penkowa M, Cáceres M, Borup R, Nielsen FC, Poulsen CB, Quintana A, Molinero A, Carrasco J, Florit S, Giralt M, Hidalgo J. Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: Insights from global gene expression profiling in wild-type and MT-I + II knockout mice. J Neurosci Res 2006;84:1452-1474.
6. Malavolta M, Cipriano C, Costarelli L, Giacconi R, Tesei S, Muti E, Piacenza F, Pierpaoli S, Larbi A, Pawelec G, Dedoussis G, Herbein G, Monti D, Jajte J, Rink L, Mocchegiani E. Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence? Rejuvenation Res 2008;11:455-459.
7. Barsyte D, Lovejoy DA, Lithgow GJ. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J 2001;15:627-634.
8. Yang X, Doser TA, Fang CX, Nunn JM, Janardhanan R, Zhu M, Sreejayan N, Quinn MT, Ren J. Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: Role of oxidative stress. FASEB J 2006;20:1024-1026.
9. Cipriano C, Malavolta M, Costarelli L, Giacconi R, Muti E, Gasparini N, Cardelli M, Monti D, Mariani E, Mocchegiani E. Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population. Biogerontology 2006;7:357-365.
10. Kayaalti Z, Sahiner L, Durakog̀ lugil ME, Söylemezog̀ lu T. Distributions of interleukin-6 (IL-6) promoter and metallothionein 2A (MT2A) core promoter region gene polymorphisms and their associations with aging in Turkish population. Arch Gerontol Geriatr 2011;53:354-358.
11. Swindell WR. Metallothionein and the biology of aging. Ageing Res Rev 2011;10:132-145.
12. Swindell WR. Gene expression profiling of long-lived dwarf mice: Longevity-associated genes and relationships with diet, gender and aging. BMC Genomics 2007;8:353.
13. Iszard MB, Liu J, Liu Y, Dalton T, Andrews GK, Palmiter RD, Klaassen CD. Characterization of metallothionein-I-transgenic mice. Toxicol Appl Pharmacol 1995;133:305-12.
14. Aughey E, Grant L, Furman BL, Dryden WF. The effects of oral zinc supplementation in the mouse. J Comp Pathol 1977;87:1-14.
15. Piantanelli L, Rossolini G, Nisbet R. Modelling survivorship kinetics: A two-parameter model. Gerontology 1992;38:30-40.
16. Piantanelli L. A mathematical model of survival kinetics. I. Theoretical basis. Arch Gerontol Geriatr 1986;5:107-118.
17. Onosaka S, Tetsuchikawahara N, Min KS. Paradigm shift in zinc: Metal pathology. Tohoku J Exp Med 2002;196: 1-7.
18. Vedell PT, Svenson KL, Churchill GA. Stochastic variation of transcript abundance in C57BL/6J mice. BMC Genomics 2011;12:167.
19. Liu J, Zhou ZX, Zhang W, Bell MW, Waalkes MP. Changes in hepatic gene expression in response to hepatoprotective levels of zinc. Liver Int 2009;29:1222-1229.
20. Flurkey K, Currer JM, Harrison DE. 2007. The mouse in aging research. In: The Mouse in Biomedical Research, 2nd ed. Fox JG, et al. (eds). American College Laboratory Animal Medicine (Elsevier), Burlington, MA, pp. 637-672.