Panton-Valentine leukocidin-associated Staphylococcus aureus necrotizing pneumonia in infants: A report of four cases and review of the literature

European Journal of Pediatrics

Volumn 171, Issue 4, 2012, Pages 711-717

  Schwartz, Kevin L ^a,b   Nourse, Clare ^c,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MATER CHILDREN S HOSPITAL   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Methicillin resistant Staphylococcus aureus; Panton Valentine Leukocidin; Staphylococcus aureus pneumonia

Indexed keywords

AMPICILLIN; AZITHROMYCIN; CEFOTAXIME; CLINDAMYCIN; COTRIMOXAZOLE; ERYTHROMYCIN; FLUCLOXACILLIN; GENTAMICIN; HYDROCORTISONE; IMMUNOGLOBULIN; LINEZOLID; PANTON VALENTINE LEUKOCIDIN; PENICILLIN G; RIFAMPICIN; VANCOMYCIN;

ABDOMINAL COMPARTMENT SYNDROME; ABDOMINAL DISTENSION; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; ASSISTED VENTILATION; BLOOD CLOTTING DISORDER; BRAIN EMBOLISM; BRAIN HEMORRHAGE; BREATHING RATE; BRONCHOPNEUMONIA; BRONCHOSCOPY; CARDIOPULMONARY INSUFFICIENCY; CASE REPORT; CHILD; COUGHING; ENDOTRACHEAL INTUBATION; ERYTHEMA; EXTRACORPOREAL OXYGENATION; FEMALE; FEVER; GRAM STAINING; HUMAN; INFANT; LETHARGY; LEUKOPENIA; LIMB ISCHEMIA; LUNG HEMORRHAGE; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIPLE ORGAN FAILURE; OXYGEN SATURATION; PLEURA EFFUSION; PLEURA FLUID; PNEUMATOCELE; PNEUMOTHORAX; PRESCHOOL CHILD; PRIORITY JOURNAL; PULSE RATE; PURPURIC RASH; PUSTULE; RESUSCITATION; SCALP; STAPHYLOCOCCAL PNEUMONIA; STAPHYLOCOCCAL SKIN INFECTION; THORAX RADIOGRAPHY; TOXIC SHOCK SYNDROME; TRACHEITIS;

BACTERIAL TOXINS; BRAIN ABSCESS; EXOTOXINS; EXTRACORPOREAL MEMBRANE OXYGENATION; FATAL OUTCOME; FEMALE; GENOTYPE; HUMANS; INFANT; LEUKOCIDINS; MALE; NECROSIS; PNEUMONIA, BACTERIAL; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TOMOGRAPHY, X-RAY COMPUTED; VIRULENCE;

EID: 84860287470     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-011-1651-y     Document Type: Article

References (40)

1. BioMerieux (2004) Vitek 2 - systems product information. Bio- Merieux, Durham, pp 1-150
2. Carrillo-Marquez MA, Hulten KG, Hammerman W, Lamberth L, Mason EO, Kaplan SL (2011) Staphylococcus aureus pneumonia in children in the era of community-acquired methicillin-resistance at Texas Children's Hospital. Pediatr Infect Dis J 30:545-550
3. Chua KYL, Seemann T, Harrison PF, Monagle S, Korman TM, Johnson PDR, Coombs GW, Howden BO, Davies JK, Howden BP, Stinear TP (2011) The dominant Australian community-acquired methicillin-resistant Staphylococcus aureus clone ST93-IV [2B] is highly virulent and genetically distinct. PLoS One 6:e25887
4. G. Coombs JP, G. Nimmo, K. Christiansen on behalf of the Australian Group for Antimicrobial Resistance. (2010) Widespread dissemination of the Panton-Valentine leukocidin positive ST93-MRSA-IV clone in the Australian community. 20th European Congress of Clinical Microbiology and Infectious Diseases, Vienna, Austria
5. Costello ME, Huygens F (2011) Diversity of community acquired MRSA carrying the PVL gene in Queensland and New South Wales, Australia. Eur J Clin Microbiol Infect Dis 30:1163-1167
6. Coyle EA (2003) Targeting bacterial virulence: the role of protein synthesis inhibitors in severe infections. Pharmacotherapy 23:638-642
7. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF (2010) Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci USA 107:5587-5592
8. Fortenberry JD, Paden ML (2006) Extracorporeal therapies in the treatment of sepsis: experience and promise. Semin Pediatr Infect Dis 17:72-79 (Pubitemid 43963529)
9. Gauduchon V, Cozon G, Vandenesch F, Genestier A-L, Eyssade N, Peyrol S, Etienne J, Lina G (2004) Neutralization of Staphylococcus aureus Panton-Valentine leukocidin by intravenous immunoglobulin in vitro. J Infect Dis 189:346-353 (Pubitemid 38147260)
10. Geng W, Yang Y, Wu D, Zhang W, Wang C, Shang Y, Zheng Y, Deng L, Fu Z, Li X, Yu S, Shen X (2010) Community-acquired, methicillin-resistant Staphylococcus aureus isolated from children with community-onset pneumonia in China. Pediatr Pulmonol 45:387-394
11. Gillet Y, Etienne J, Lina G, Vandenesch F (2008) Association of necrotizing pneumonia with Panton-Valentine leukocidinproducing Staphylococcus aureus, regardless of methicillin resistance. Clin Infect Dis 47:985-986
12. Gillet Y, Issartel B, Vanhems P, Fournet J-C, Lina G, Bes M, Vandenesch F, Pièmont Y, Brousse N, Floret D, Etienne J (2002) Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet 359:753-759 (Pubitemid 34215075)
13. Gonzalez BE, Hulten KG, Dishop MK, Lamberth LB, Hammerman WA, Mason EO, Kaplan SL (2005) Pulmonary manifestations in children with invasive community-acquired Staphylococcus aureus infection. Clin Infect Dis 41:583-590 (Pubitemid 41170343)
14. Gubbay JB, Gosbell IB, Barbagiannakos T, Vickery AM, Mercer JL, Watson M (2008) Clinical features, epidemiology, antimicrobial resistance, and exotoxin genes (including that of Panton- Valentine leukocidin) of gentamicin-susceptible methicillinresistant Staphylococcus aureus (GS-MRSA) isolated at a paediatric teaching hospital in New South Wales, Australia. Pathology 40:64-71 (Pubitemid 350172968)
15. Hinds S MT, Tilse M. (2009) CLSI (Clinical and Laboratory Standards Institute) susceptibility testing. Mater Pathology Microbiology Protocols [serial on the Internet]
16. Ho PL,WongMP, Lai EL, Chan KH, Chiu SS (2008) DNA typing of cytological samples for retrospective identification of an early case of Panton-Valentine leucocidin-positive, community-associated methicillin-resistant Staphylococcus aureus pneumonia. J Clin Microbiol 46:2457-2458
17. Hussain A, Robinson G, Malkin J, Duthie M, Kearns A, Perera N (2007) Purpura fulminans in a child secondary to Panton-Valentine leukocidin-producing Staphylococcus aureus. J Med Microbiol 56:1407-1409 (Pubitemid 350105613)
18. Huygens F, Inman-Bamber J, NimmoGR, MunckhofW, Schooneveldt J, Harrison B, McMahon JA, Giffard PM (2006) Staphylococcus aureus genotyping using novel real-time PCR formats. J Clin Microbiol 44:3712-3719 (Pubitemid 46768785)
19. Kaplan SL, Afghani B, Lopez P, Wu E, Fleishaker D, Edge- Padbury B, Naberhuis-Stehouwer S, Bruss JB (2003) Linezolid for the treatment of methicillin-resistant Staphylococcus aureus infections in children. Pediatr Infect Dis J 22:S178-S185 (Pubitemid 37158767)
20. Kudva A, Scheller EV, Robinson KM, Crowe CR, Choi SM, Slight SR, Khader SA, Dubin PJ, Enelow RI, Kolls JK, Alcorn JF (2011) Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. J Immunol 186:1666-1674
21. Le Thomas I, Mariani-Kurkdjian P, Collignon A, Gravet A, Clermont O, Brahimi N, Gaudelus J, Aujard Y, Navarro J, Beaufils F, Bingen E (2001) Breast milk transmission of a Panton-Valentine leukocidinproducing Staphylococcus aureus strain causing infantile pneumonia. J Clin Microbiol 39:728-729 (Pubitemid 32150847)
22. Lewis D, Campbell R, Cookson B, Day C, Duerden B, Duckworth G, Hawkey P, Howe R, Jeffries D, Kearns A,MorganM, McCartney C, Nathwani D, Pearson A, Steer J (2008) Steering Group on Health Care Associated Infection. Guidance on the diagnosis and management of PVL-associated Staphylococcus aureus infections (PVL-SA) in England, 2nd edn. Health Protection Agency, London
23. Morgan MS (2007) Diagnosis and treatment of Panton-Valentine leukocidin (PVL)-associated staphylococcal pneumonia. Int J Antimicrob Agents 30:289-296 (Pubitemid 47361709)
24. Mushtaq F, Hildrew S, Okugbeni G, Ellis RW, Deshpande S (2008) Necrotizing haemorrhagic pneumonia proves fatal in an immunocompetent child due to Panton-Valentine leukocidin, toxic shock syndrome toxins 1 and 2 and enterotoxin C-producing Staphylococcus aureus. [Erratum appears in Acta Paediatr. 2008 Aug;97(8):1153 Note: Deshpande, Sanjay [added]]. Acta Paediatrica 97:985-987 (Pubitemid 351792815)
25. Nehra D, Goldstein AM, Doody DP, Ryan DP, Chang Y, Masiakos PT (2009) Extracorporeal membrane oxygenation for nonneonatal acute respiratory failure: the Massachusetts General Hospital experience from 1990 to 2008. Arch Surg 144:427-432
26. Nimmo G, Schooneveldt J, Sutherland J, Power S, Olesen D, Selvey C, Beard F, Jones M, Paterson D (2010) Epidemiology of non-multiresistant methicillin-resistant Staphylococcus aureus infection in Queensland, Australia: associations with indigenous populations and Panton-Valentine leukocidin. Eur J Clin Microbiol Infect Dis 29:1253-1259
27. Noah MA, Dawrant M, Faulkner GM, Hill A-M, Harvey C, Hussain A, Jenkins DR, Nichani S, Peek GJ, Sosnowski AW, Firmin RK (2010) Panton-Valentine leukocidin expressing Staphylococcus aureus pneumonia managed with extracorporeal membrane oxygenation: experience and outcome. Critical Care Medicine 38:2250-2253 2210.1097/CCM.2250b2013e3181f26490
28. Nourse C, Starr M, Munckhof W (2007) Community-acquired methicillin-resistant Staphylococcus aureus causes severe disseminated infection and deep venous thrombosis in children: literature review and recommendations for management. J Paediatr Child Health 43:656-661 (Pubitemid 47390255)
29. Otto M (2010) Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu Rev Microbiol 64:143-162
30. Rougemont A-L, Buteau C, Ovetchkine P, Cl B, Fournet J-C, DeB-D S (2009) Fatal cases of Staphylococcus aureus pleural empyema in infants. Pediatr Dev Pathol 12:390-393
31. Rouzic N, Janvier F, Libert N, Javouhey E, Lina G, Nizou J-Y, Pasquier P, Stamm D, Brinquin L, Pelletier C, Vandenesch F, Floret D, Etienne J, Gillet Y (2010) Prompt and successful toxintargeting treatment of three patients with necrotizing pneumonia due to Staphylococcus aureus strains carrying the Panton-Valentine leukocidin genes. J Clin Microbiol 48:1952-1955
32. Rubinstein E, Kollef MH, Nathwani D (2008) Pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis 46 (Suppl 5):S378-S385 (Pubitemid 351717325)
33. Shahangian A, Chow EK, Tian X, Kang JR, Ghaffari A, Liu SY, Belperio JA, Cheng G, Deng JC (2009) Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Investig 119:1910-1920
34. Stroud MH, Okhuysen-Cawley R, Jaquiss R, Berlinski A, Fiser RT (2007) Successful use of extracorporeal membrane oxygenation in severe necrotizing pneumonia caused by Staphylococcus aureus. Pediatr Crit Care Med 8:282-287 (Pubitemid 46743742)
35. Thomas B, Pugalenthi A, Chilvers M (2009) Pleuropulmonary complications of PVL-positive Staphylococcus aureus infection in children. Acta Paediatr 98:1372-1375
36. Tseng M-H, Wei B-H, Lin W-J, Lu J-J, Lee S-Y, Wang S-R, Chen S-J, Wang C-C (2005) Fatal sepsis and necrotizing pneumonia in a child due to community-acquired methicillinresistant Staphylococcus aureus: case report and literature review. Scand J Infect Dis 37:504-507 (Pubitemid 41038525)
37. Vardakas KZ, Matthaiou DK, Falagas ME (2009) Incidence, characteristics and outcomes of patients with severe community acquired-MRSA pneumonia. Eur Respir J 34:1148-1158
38. Wenzel JJ, Hentschel J, Silvis W, Permanetter W, Mattes J, Kochanowski B, Herterich R, Jilg W, Linde HJ (2009) Rapidly fatal necrotizing pneumonia in a 12-year-old boy caused by co-infection with parainfluenza virus type 1 and Panton-Valentine leukocidin (PVL)-positive methicillin-sensitive Staphylococcus aureus. Infection 37:75-77
39. Wikler MA CF, Bush K, Dudley MN, Eliopoulos GM, Hardy DJ, et al. (2009) Performance standards for antimicrobial disk susceptibility tests; approved standard, 10 edn. Clinical and Laboratory Standards Institute, Wayne [serial on the Internet] 29
40. Yanagihara K, Kihara R, Araki N, Morinaga Y, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kohno S, Tsukamoto K, Kamihira S (2009) Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection. Int J Antimicrob Agents 34:477-481