Intensified neoadjuvant chemoradiotherapy in locally advanced rectal cancer - Impact on long-term quality of life

European Journal of Surgical Oncology

Volumn 38, Issue 6, 2012, Pages 472-477

  Kripp, M ^a   Wieneke, J ^a   Kienle, P ^a   Welzel, G ^a   Brade, J ^a   Horisberger, K ^a   Wenz, F ^a   Post, S ^a   Gencer, D ^a   Hofmann, W K ^a   Hofheinz, R D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Neoadjuvant chemoradiotherapy; Quality of life; Rectal cancer

Indexed keywords

CAPECITABINE; CETUXIMAB; FLUOROURACIL; IRINOTECAN;

ABDOMINAL PAIN; ADJUVANT CHEMOTHERAPY; ADULT; ADVANCED CANCER; AGED; ANOREXIA; ARTICLE; CANCER FATIGUE; CANCER PAIN; CHEMOTHERAPY INDUCED EMESIS; CLINICAL FEATURE; CONSTIPATION; DEFECATION URGENCY; DIARRHEA; DYSPNEA; DYSURIA; FECES INCONTINENCE; FEMALE; FLATULENCE; HAIR LOSS; HUMAN; INSOMNIA; INTENSIFIED PREOPERATIVE CHEMORADIOTHERAPY; MAJOR CLINICAL STUDY; MALE; OCCULT BLOOD; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RECTUM CANCER; RECTUM SURGERY; SIDE EFFECT; SKIN DISEASE; TASTE DISORDER; URINARY FREQUENCY; XEROSTOMIA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMORADIOTHERAPY, ADJUVANT; CLINICAL TRIALS, PHASE I AS TOPIC; CLINICAL TRIALS, PHASE II AS TOPIC; CLINICAL TRIALS, PHASE III AS TOPIC; CONFOUNDING FACTORS (EPIDEMIOLOGY); DIARRHEA; FEMALE; FLUOROURACIL; GASTROINTESTINAL TRACT; HEALTH STATUS; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; QUALITY OF LIFE; QUESTIONNAIRES; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 84860278120     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2012.02.002     Document Type: Article

References (23)

1. K.C. Peeters, C.A. Marijnen, I.D. Nagtegaal Dutch Colorectal Cancer Group The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma Ann Surg 246 5 2007 693 701 (Pubitemid 350035641)
2. J.P. Gérard, T. Conroy, and F. Bonnetain Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203 J Clin Oncol 24 28 2006 4620 4625 (Pubitemid 46630960)
3. J.F. Bosset, L. Collette, and G. Calais EORTC radiotherapy group trial 22921. Chemotherapy with preoperative radiotherapy in rectal cancer N Engl J Med 355 11 2006 Sep 14 1114 1123 (Pubitemid 44394918)
4. R. Sauer, H. Becker, W. Hohenberger German Rectal Cancer Study Group Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 17 2004 1731 1740
5. J.E. Tepper, M. O'Connell, and D. Niedzwiecki Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control-final report of intergroup 0114 J Clin Oncol 20 7 2002 1744 1750 (Pubitemid 34273262)
6. M.J. O'Connell, J.A. Martenson, and H.S. Wieand Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery N Engl J Med 331 8 1994 502 507
7. G. Hartung, A. Kopp-Schneider, and P. Diezler Adjuvant radio-chemotherapy with 5-fluorouracil and leucovorin in stage II and III rectal cancer: 12 months vs. 6 months of therapy. A study of the Association for Medical Oncology of the German Cancer Society Onkologie 23 2000 334 339
8. R. Hofheinz, F. Wenz, and S. Post Capecitabine (Cape) versus 5-fluorouracil (5-FU)-based (neo)adjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC): long-term results of a randomized, phase III trial J Clin Oncol 29 Suppl. 2011 3504 [abstr.]
9. M. Maas, P.J. Nelemans, and V. Valentini Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data Lancet Oncol 11 9 2010 835 844
10. C. Rödel, and R. Sauer Integration of novel agents into combined-modality treatment for rectal cancer patients Strahlenther Onkol 183 5 2007 227 235 (Pubitemid 46725993)
11. C. Aschele, L. Cionini, and S. Lonardi Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial J Clin Oncol 29 20 2011 2773 2780
12. J.P. Gérard, D. Azria, and S. Gourgou-Bourgade Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-prodige 2 J Clin Oncol 28 10 2010 1638 1644
13. M. Tiv, M. Puyraveau, and L. Mineur Long-term quality of life in patients with rectal cancer treated with preoperative (chemo)-radiotherapy within a randomized trial Cancer Radiother 14 6-7 2010 530 534
14. M. Brændengen, K.M. Tveit, K. Bruheim, M. Cvancarova, Berglund, and B. Glimelius Late patient-reported toxicity after preoperative radiotherapy or chemoradiotherapy in nonresectable rectal cancer: results from a randomized phase III study Int J Radiat Oncol Biol Phys 81 4 2011 1017 1024
15. F. Willeke, K. Horisberger, and U. Kraus-Tiefenbacher A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer Br J Cancer 96 6 2007 912 917 (Pubitemid 46452282)
16. K. Horisberger, A. Treschl, S. Mai MARGIT (Mannheimer Arbeitsgruppe für Gastrointestinale Tumoren) Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: results of a Phase II MARGIT trial Int J Radiat Oncol Biol Phys 74 5 2009 1487 1493
17. N.K. Aaronson, S. Ahmedzai, and B. Bergman The European Organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology J Natl Cancer Inst 85 5 1993 365 376 (Pubitemid 23073154)
18. R.N. Whistance, T. Conroy, W. Chie European Organisation for the Research and Treatment of Cancer Quality of Life Group Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer Eur J Cancer 45 17 2009 3017 3026
19. P. Fayers, N. Aaronson, K. Bjordal, and E.V. Sullivan EORTC QLQ-C30 scoring manual 1995 EORTC Quality of Life Study Group. EORTC Brüssel
20. D. Osoba, G. Rodrigues, J. Myles, B. Zee, and J. Pater Interpreting the significance of changes in health-related quality-of-life scores J Clin Oncol 16 1 1998 139 144 (Pubitemid 28041591)
21. V. Arndt, H. Merx, C. Stegmaier, H. Ziegler, and H. Brenner Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study J Clin Oncol 22 23 2004 Dec 1 4829 4836
22. M. Dahlberg, B. Glimelius, W. Graf, and L. Phlman Preoperative irradiation affects functional results after surgery for rectal cancer: results from a randomized study Dis Colon Rectum 41 5 1998 543 549
23. R. Schwarz, and A. Hinz Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population Eur J Cancer 37 11 2001 1345 1351 (Pubitemid 32588744)