Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells

Current Molecular Medicine

Volumn 12, Issue 4, 2012, Pages 467-475

  Manku, G ^a,b   Wang, Y ^c,d   Thuillier, R ^c,e   Rhodes, C ^c   Culty, M ^a,b,c  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e POITIERS UNIVERSITY HOSPITAL   (France)

Author keywords

Development; Germ cells; Testis; TSPO

Indexed keywords

ESTRADIOL; MEMBRANE PROTEIN; MESSENGER RNA; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PLATELET DERIVED GROWTH FACTOR; TESTOSTERONE; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENT; FETUS; GERM CELL; GONOCYTE; HUMAN; HUMAN CELL; LEYDIG CELL; MALE; MALE FERTILITY; MEIOSIS; MITOSIS; NEWBORN; NONHUMAN; PACHYTENE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOZOON; STEM CELL; STEROIDOGENESIS; TESTIS;

EID: 84860269312     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/156652412800163389     Document Type: Article

References (21)

1. Papadopoulos V, Baraldi M, Guilarte TR, et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 2006; 27: 402-9.
2. Delavoie F, Li H, Hardwick M, et al. In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding. Biochemistry 2003; 42: 4506-19.
3. Hardwick M, Fertikh D, Culty M, Li H, Vidic B, Papadopoulos V. Peripheral-type benzodiazepine receptor (TSPO) in human breast cancer: correlation of breast cancer cell aggressive phenotype with TSPO expression, nuclear localization, and TSPO-mediated cell proliferation and nuclear transport of cholesterol. Cancer Res 1999; 59: 831-42
4. Corsi L, Geminiani E, Avallone R, Baraldi M. Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation. Life Sci 2005; 76: 2523-33.
5. Veenman L, Papadopoulos V, Gavish M. Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des 2007; 13: 2385-405.
6. Batarseh A, Papadopoulos V. Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol 2010; 327: 1-12.
7. Culty M. Gonocytes, the forgotten cells of the germ cell lineage. Birth Defects Research Part C; 2009; 87: 1-26.
8. Russell LD, Ettlin RA, Sinha Hikim AP, Clegg ED. Histological and histopathological evaluation of the testis. Clearwater FL, Cache River Press Eds. 1990.
9. Thuillier R, Mazer M, Manku G, Boisvert A, Wang Y, Culty M. Interdependence of PDGF and estrogen signaling pathways in inducing neonatal rat testicular gonocytes proliferation. Biol Reprod 2010; 82: 825-36.
10. Wang Y, Culty M. Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation. Endocrinology 2007; 148: 2233-50.
11. Li H, Yao Z, Degenhardt B, Teper G, Papadopoulos V. Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proc Natl Acad Sci USA 2001; 98: 1267-72.
12. Thuillier R, Manku G, Wang Y, Culty M. Changes in MAPK pathway in neonatal and adult testis following fetal estrogen exposure and effects on rat testicular cells. Microscopy Research and Techniques. Microsc Res Tech 2009; 72: 773-86.
13. Culty M, Thuillier R, Li W, et al. In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production. Biol Reprod 2008; 78: 1018-1028.
14. Clermont Y, Perey B. Quantitative study of the cell population of the seminiferous tubules in immature rats. Am J Anat 1957; 100: 241-67.
15. Visintin R, Amon A. The nucleolus: the magician's hat for cell cycle tricks. Curr Opin Cell Biol 2000; 12: 372-7.
16. Varga B, Markó K, Hádinger N, et al. Translocator protein (TSPO 18kDa) is expressed by neural stem and neuronal precursor cells. Neurosci Lett 2009; 462: 257-62.
17. Lee DH, Kang SK, Lee RH, et al. Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells. Cell Physiol 2004; 198: 91-9.
18. Ohta H, Yomogida K, Dohmae K, Nishimune Y. Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF. Development 2000; 127: 2125-31.
19. Fan J, Rone MB, Papadopoulos V. Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. J Biol Chem 2009; 284: 30484-97.
20. Simos G, Maison C, Georgatos SD. Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope. J Biol Chem 1996; 271: 12617-25.
21. Papadopoulos V, Amri H, Boujrad N, et al. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids 1997; 62: 21-8.