Androgen receptor-CAG repeats in infertile Egyptian men

Andrologia

Volumn 44, Issue 3, 2012, Pages 147-151

  Mostafa, T ^a   El Shahid, L H ^b   El Azeem, A A ^b   Shaker, O ^a   Gomaa, H ^a   Abd El Hamid, H M ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b AL AZHAR UNIVERSITY   (Egypt)

Author keywords

Azoospermia; CAG; Male infertility; Semen TESE; Testis

Indexed keywords

ANDROGEN RECEPTOR;

ADULT; ARTICLE; AZOOSPERMIA; CAG REPEAT; CONTROLLED STUDY; CORRELATION ANALYSIS; EGYPT; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; NONOBSTRUCTIVE AZOOSPERMIA; OLIGOASTHENOTERATOZOOSPERMIA; SPERMATOZOON COUNT; TESTICULAR SPERM EXTRACTION; TESTIS SIZE;

ADULT; CELL SEPARATION; CODON; EGYPT; EUROPEAN CONTINENTAL ANCESTRY GROUP; GLUTAMINE; HUMANS; INFERTILITY, MALE; MALE; OLIGOSPERMIA; RECEPTORS, ANDROGEN; SPERM COUNT; SPERM MOTILITY; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84860255137     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2010.01125.x     Document Type: Article

References (38)

1. Akinloye O, Gromoll J, Nieschlag E, Simoni M (2009) Androgen receptor gene CAG and GGN polymorphisms in infertile Nigerian men. J Endocrinol Invest 32:797-804.
2. Asatiani K, von Eckardstein S, Simoni M, Gromoll J, Nieschlag E (2003) CAG repeat length in the androgen receptor gene affects the risk of male infertility. Int J Androl 26:255-261.
3. Badran WA, Fahmy I, Abdel-Megid WM, Elder K, Mansour R, Kent-First M (2009) Length of androgen receptor-CAG repeats in fertile and infertile Egyptian men. J Androl 30:416-425.
4. Canale D, Caglieresi C, Moschini C, Liberati CD, Macchia E, Pinchera A, Martino E (2005) Androgen receptor polymorphism (CAG repeats) and androgenicity. Clin Endocrinol (Oxf) 63:356-661.
5. Dadze S, Wieland C, Jakubiczka S, Funke K, Schroder E, Royer-Pokora B, Willers R, Wieacker PF (2000) The size of the CAG repeat in exon 1 of the androgen receptor gene shows no significant relationship to impaired spermatogenesis in an infertile Caucasoid sample of German origin. Mol Hum Reprod 6:207-214.
6. Dakouane-Giudicelli M, Legrand B, Bergere M, Giudicelli Y, Cussenot O, Selva J (2006) Association between androgen receptor gene CAG trinucleotide repeat length and testicular histology in older men. Fertil Steril 86:873-877.
7. Davis-Dao CA, Tuazon ED, Sokol RZ, Cortessis VK (2007) Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis. J Clin Endocrinol Metab 92:4319-4326.
8. Dhillon VS, Husain SA (2003) Cytogenetic and molecular analysis of the Y chromosome: absence of a significant relationship between CAG repeat length in exon 1 of the androgen receptor gene and infertility in Indian men. Int J Androl 26:286-295.
9. Dowsing AT, Yong EL, Clark M, McLachlan RI, de Kretser DM, Trounson AO (1999) Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene. Lancet 354:640-643.
10. Erasmuson T, Sin IL, Sin FY (2003) Absence of association of androgen receptor trinucleotide expansion and poor semen quality. Int J Androl 26:46-51.
11. Ferlin A, Bartoloni L, Rizzo G, Roverato A, Garolla A, Foresta C (2004) Androgen receptor gene CAG and GGC repeat lengths in idiopathic male infertility. Mol Hum Reprod 10:417-421.
12. Fesaǐ OA, Kravchenko SA, Tyrkus MIa, Makukh GV, Zinchenko VM, Strelko GV, Livshits LA (2009) Androgen receptor CAG gene polymorphism in men with azoospermia and oligozoospermia in Ukraine. Tsitol Genet 43:45-51.
13. Franken DR, Barendsen R, Kruger TF (2000) A continuous quality control program for strict sperm morphology. Fertil Steril 74:721-724.
14. Giwercman YL, Xu C, Arver S, Pousette A, Reneland R (1998) No association between the androgen receptor gene CAG repeat and impaired sperm production in Swedish men. Clin Genet 54:435-436.
15. Katagiri Y, Neri QV, Takeuchi T, Moy F, Sills ES, Palermo GD (2006) Androgen receptor CAG polymorphism (Xq11-12) status and human spermatogenesis: a prospective analysis of infertile males and their offspring conceived by intracytoplasmic sperm injection. Int J Mol Med 18:405-413.
16. Lavery R, Houghton JA, Nolan A, Glennon M, Egan D, Maher M (2005) CAG repeat length in an infertile male population of Irish origin. Genetica 123:295-302.
17. Li Y, Wang LA, Wu TX (2009) Association of male infertility with (CAG)n polymorphism of the androgen receptor gene: a meta-analysis. Zhonghua Nan Ke Xue 15:809-813.
18. Lim HN, Chen H, McBride S, Dunning AM, Nixon RM, Hughes IA, Hawkins JR (2000) Longer polyglutamine tracts in the androgen receptor are associated with moderate to severe undermasculinized genitalia in XY males. Hum Mol Genet 9:829-834.
19. Lund A, Tapanainen JS, Lähdetie J, Savontaus ML, Aittomäki K (2003) Long CAG repeats in the AR gene are not associated with infertility in Finnish males. Acta Obstet Gynecol Scand 82:162-166.
20. Mengual L, Oriola J, Ascaso C, Ballescà JL, Oliva R (2003) An increased CAG repeat length in the androgen receptor gene in azoospermic ICSI candidates. J Androl 24:279-284.
21. Mickle JE, Cutting GR (2000) Genotype-phenotype relationships in cystic fibrosis. Med Clin North Am 84:597-607.
22. Mifsud A, Sim CK, Boettger-Tong H, Moreira S, Lamb DJ, Lipshultz LI, Yong EL (2001) Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: molecular markers of male infertility risk. Fertil Steril 75:275-281.
23. Pan H, Li YY, Li TC, Tsai WT, Li SY, Hsiao KM (2002) Increased (CTG/CAG)(n) lengths in myotonic dystrophy type 1 and Machado-Joseph disease genes in idiopathic azoospermia patients. Hum Reprod 17:1578-1583.
24. Patrizio P, Leonard DG, Chen KL, Hernandez-Ayup S, Trounson AO (2001) Larger trinucleotide repeat size in the androgen receptor gene of infertile men with extremely severe oligozoospermia. J Androl 22:444-448.
25. Perrin SJ, Yves Herve P, Leonard G, Perron M, Paus T (2008) Growth of white matter in the adolescent brain: role of testosterone and androgen receptor. J Neurosci 28:9519-9524.
26. Poongothai J, Gopenath TS, Manonayaki S (2009) Genetics of human male infertility. Singapore Med 50:336-347.
27. Rajpert-De Meyts E, Leffers H, Petersen JH, Andersen AG, Carlsen E, Jørgensen N, Skakkebaek NE (2002) CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men. Lancet 359:44-46.
28. Ruhayel Y, Lundin K, Giwercman Y, Halldén C, Willén M, Giwercman A (2004) Androgen receptor gene GGN and CAG polymorphisms among severely oligozoospermic and azoospermic Swedish men. Hum Reprod 19:2076-2083.
29. Saare M, Belousova A, Punab M, Peters M, Haller K, Ausmees K, Poolamets O, Karro H, Metspalu A, Salumets A (2008) Androgen receptor gene haplotype is associated with male infertility. Int J Androl 31:395-402.
30. Sasagawa I, Suzuki Y, Ashida J, Nakada T, Muroya K, Ogata T (2001) CAG repeat length analysis and mutation screening of the androgen receptor gene in Japanese men with idiopathic azoospermia. J Androl 22:804-808.
31. Tufan AC, Satiroglu-Tufan NL, Aydinuraz B, Satiroglu MH, Aydos K, Bagci H (2005) No association of the CAG repeat length in exon 1 of the androgen receptor gene with idiopathic infertility in Turkish men: implications and literature review. Tohoku J Exp Med 206:105-115.
32. Tut TG, Ghadessy FJ, Trifiro MA, Pinsky L, Yong EL (1997) Long polyglutamine tracts in the androgen receptor are associated with reduced transactivation, impaired sperm production and male infertility. J Clin Endocrinol Metab 82:3777-3782.
33. Van Golde R, Van Houwelingen K, Kiemeney L, Kremer J, Tuerlings J, Schalken J, Meuleman E (2002) Is increased CAG repeat length in the androgen receptor gene a risk factor for male subfertility? J Urol 167:621-623.
34. Von Eckardstein S, Syska A, Gromoll J, Kamischke A, Simoni M, Nieschlag E (2001) Inverse correlation between sperm concentration and number of androgen receptor CAG repeats in normal men. J Clin Endocrinol Metab 86:2585-2590.
35. Wallerand H, Remy-Martin A, Chabannes E, Bermont L, Adessi GL, Bittard H (2001) Relationship between expansion of the CAG repeat in exon 1 of the androgen receptor gene and idiopathic male infertility. Fertil Steril 76:769-774.
36. Westerveld H, Visser L, Tanck M, van der Veen F, Repping S (2008) CAG repeat length variation in the androgen receptor gene is not associated with spermatogenic failure. Fertil Steril 89:253-259.
37. WHO (1999). Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, 4th edn. Cambridge University Press. Cambridge.
38. Yoshida KI, Yano M, Chiba K, Honda M, Kitahara S (1999) CAG repeat length in the androgen receptor gene is enhanced in patients with idiopathic azoospermia. Urology 54:1078-1081.