Relationship between expansion of the CAG repeat in exon 1 of the androgen receptor gene and idiopathic male infertility

Fertility and Sterility

Volumn 76, Issue 4, 2001, Pages 769-774

  Wallerand, Hervé ^a,c   Rémy Martin, Agnès ^b   Chabannes, Eric ^a   Bermont, Laurent ^b   Adessi, Gérard Louis ^b   Bittard, Hugues ^a  

^a Service d'Urologie Andrologie   (France)

^b Service de Biochimie Hormonale   (France)

^c Centre Hospitalo Universitaire Saint Jacques   (France)

Author keywords

Androgen receptor gene; CAG repeat length polymorphism; Male idiopathic infertility

Indexed keywords

ANDROGEN RECEPTOR; CYSTEINYLALANYLGLYCINE; TRINUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; AZOOSPERMIA; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROPHORESIS; EXON; FRANCE; GENE MUTATION; HORMONE DETERMINATION; HUMAN; MALE; MALE FERTILITY; MALE INFERTILITY; MEDICAL ASSESSMENT; OLIGOSPERMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE; RETROSPECTIVE STUDY; SEMEN ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; SPERMATOGENESIS;

ADULT; DNA MUTATIONAL ANALYSIS; EXONS; HUMANS; INFERTILITY, MALE; MALE; MIDDLE AGED; RECEPTORS, ANDROGEN; REFERENCE VALUES; RETROSPECTIVE STUDIES; TRINUCLEOTIDE REPEATS;

EID: 0034813780     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(01)01987-2     Document Type: Article

References (21)

1. Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity
2. Androgen receptor defects: Historical, clinical, and molecular perpectives
3. Cloning of human androgen receptor complementary DNA and localization to the X chromosome
4. Androgen insensitivity
5. Identification of two transcription activation units in the N-terminal domain of the human androgen receptor
6. Trinucleotide repeat expansion in neurological disease
7. Abnormal androgen receptor binding affinity in subjects with Kennedy's disease (spinal and bulbar muscular atrophy)
8. Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility
9. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function
10. No association between the androgen receptor gene CAG repeat and impaired sperm production in Swedish men
11. The size of the CAG repeat in exon 1 of the androgen receptor gene shows no significant relationship to impaired spermatogenesis in an infertile Caucasoid sample of German origin
12. Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene
13. CAG repeat length in the androgen receptor gene is enhanced in patients with idiopathic azoospermia
14. Evidence for a partial deletion in the androgen receptor gene in a phenotypic male with azoospermia
15. Pregnancy after hormonal correction of severe spermatogenic defect due to mutation in androgen receptor gene
16. An androgen receptor mutation causing androgen resistance in undervirilized male syndrome
17. Mild androgen insensitivity and male infertility: Substitution in the ligand-binding domain of the androgen receptor that impairs transactivation but not androgen binding
18. A new point mutation of the androgen receptor in a patient with partial androgen resistance and severe oligozoospermia
19. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer
20. Association between CAG repeat number in the androgen receptor and male infertility in a Belgian study
21. Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length