Clinical relevance of HLA donor-specific antibodies detected by single antigen assay in kidney transplantation

Nephrology Dialysis Transplantation

Volumn 27, Issue 3, 2012, Pages 1231-1238

  Caro Oleas, José Luis ^a   González Escribano, María Francisca ^a   González Roncero, Francisco Manuel ^a   Acevedo Calado, María José ^a   Cabello Chaves, Virginia ^a   Gentil Govantes, Miguel Ángel ^a   Núñez Roldán, Antonio ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

Donor specific antibodies; Graft survival; HLA; Humoral rejection

Indexed keywords

ALLOANTIBODY; HLA ANTIBODY; HLA ANTIGEN CLASS 1 ANTIBODY; HLA ANTIGEN CLASS 2 ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; CHILD; CONTROLLED STUDY; CYTOTOXICITY TEST; FEMALE; FLUORESCENCE ANALYSIS; GRAFT SURVIVAL; HUMAN; IMMUNOASSAY; KIDNEY ALLOGRAFT; KIDNEY DONOR; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ADULT; AGED; ANTIBODY SPECIFICITY; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 84860248995     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr429     Document Type: Article

References (26)

1. Gebel HM, Bray RA, Nickerson P. Pre-transplant assessment of donor-reactive, HLA-specific antibodies in renal transplantation: contraindication vs. risk. Am J Transplant 2003; 3: 1488-1500
2. Class FHJ. Clinical relevance of circulating donor-specific HLA antibodies. Curr Opin Organ Transplant 2010; 15: 462-466
3. Patel R, Terasaki PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 1969; 280: 735-739
4. Cross DE, Whittier FC, Weaver P et al. A comparison of the antiglobulin versus extended incubation time crossmatch: results in 223 renal transplants. Transplant Proc 1969; 9: 1803-1806
5. Fuller TC, Cosimi AB, Russell PS. Use of an antiglobulin-ATG reagent for detection of low levels of alloantibody-improvement of allograft survival in presensitized recipients. Transplant Proc 1978; 10: 463-466
6. Johnson AH, Rossen RD, Butler WT. Detection of alloantibodies using a sensitive antiglobulin microcytotoxicity test: identification of low levels of preformed antibodies in accelerated allograft rejection. Tissue Antigens 1972; 2: 215-226
7. Terasaki PI, McClelland JD. Microdroplet assay of human serum cytotoxins. Nature 1964; 204: 998-1000
8. Kissmeyer-Nielsen F, Olsen S, Petersen VP et al. Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells. Lancet 1966; 2: 662-665
9. Racusen LC, Haas M. Antibody-mediated rejection in renal allografts: lessons from pathology. Clin J Am Soc Nephrol 2006; 1: 415-420
10. Iwaki Y, Lau M, Cook DJ et al. Crossmatching with B and T cells and flow cytometry. Clin Transpl 1986:277-284
11. Scornik JC. Detection of alloantibodies by flow cytometry: relevance to clinical transplantation. Cytometry 1995; 22: 259-263
12. Patel AM, Pancoska C, Mulgaonkar S et al. Renal transplantation in patients with pre-transplant donor-specific antibodies and negative flow cytometry crossmatches. Am J Transplant 2007; 7: 2371-2377
13. Gupta A, Iveson V, Varagunam M et al. Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplant: are they relevant? Transplantation 2008; 85: 1081-1082
14. van den Berg-Loonen EM, Billen EV, Voorter CE et al. Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients. Transplantation 2008; 85: 1086-1090
15. Phelan D, Mohanakumar T, Ramachandran S et al. Living donor renal transplantation in the presence of donor-specific human leukocyte antigen antibody detected by solid-phase assay. Hum Immunol 2009; 70: 584-588
16. Aubert V, Venetz JP, Pantaleo G et al. Are all donor-specific antibodies detected by solid-phase assay before transplantation clinically relevant? Transplantation 2009; 87: 1897-1898
17. Vlad G, Ho EK, Vasilescu ER et al. Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival. Hum Immunol 2009; 70: 589-594
18. Gupta A, Sinnott P. Clinical relevance of pretransplant human leukocyte antigen donor-specific antibodies renal in renal patients waiting for a transplant: a risk factor. Hum Immunol 2009; 70: 618-622
19. Gebel HM, Moussa O, Eckels DD et al. Donor-reactive HLA antibodies in renal allograft recipients: considerations, complications, and conundrums. Hum Immunol 2009; 70: 610-617
20. Singh N, Djamali A, Lorentzen D et al. Pretransplant donor-specific antibodies detected by single-antigen bead flow cytometry are associated with inferior kidney transplant outcomes. Transplantation 2010; 90: 1079-1084
21. Süsal C, Döhler B, Opelz G. Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk for graft failure: a collaborative transplant study report. Hum Immunol 2009; 70: 569-573
22. Süsal C, Ovens J, Mahmoud K et al. No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-antigen testing: a collaborative transplant study report. Transplantation 2011; 15: 883-887
23. Willicombe M, Brookes P, Santos-Nunez E et al. Outcome of patients with preformed donor-specific antibodies following alemtuzumab induction and tacrolimus monotherapy. Am J Transplant 2011; 11: 470-477
24. Lefaucheur C, Loupy A, Hill GS et al. Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation. J Am Soc Nephrol 2010; 21: 1398-1406
25. Amico P, Hönger G, MayrM et al. Clinical relevance of pretransplant donor-specific HLA antibodies detected by single antigen flow-beads. Transplantation 2009; 87: 1681-1688
26. Cecka JM, Kucheryavaya AY, Reinsmoen NL et al. Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches. Am J Transplant 2010; 10: 1-6