Hemodynamic, vascular, and reproductive impact of FMS-like tyrosine kinase 1 (FLT1) Blockade on the uteroplacental circulation during normal mouse pregnancy

Biology of Reproduction

Volumn 86, Issue 2, 2012, Pages

  Khankin, Eliyahu V ^a   Mandala, Maurizio ^b,c   Colton, Ilsley ^c   Karumanchi, S Ananth ^a   Osol, George ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALABRIA   (Italy)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

Angiogenesis; FLT1; Pregnancy; sFLT1; Ultrasound; Uterine artery; Uterine vein; Vascular remodeling; VEGF

Indexed keywords

ANTIBODY; VASCULOTROPIN RECEPTOR 1; ANTIIDIOTYPIC ANTIBODY; FLT1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTERY DIAMETER; ARTICLE; BLOOD FLOW VELOCITY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GESTATIONAL AGE; HEMODYNAMICS; MOUSE; NONHUMAN; PLACENTA CIRCULATION; PREGNANCY; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; ANGIOGENESIS; ANIMAL; BLOOD FLOW; BREEDING; DRUG ANTAGONISM; DRUG EFFECT; FETUS; FETUS RESORPTION; LITTER SIZE; MOUSE STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA; REPRODUCTION; VASCULARIZATION;

MURINAE; MUS;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; BLOOD FLOW VELOCITY; FEMALE; FETAL RESORPTION; FETUS; HEMODYNAMICS; LITTER SIZE; MICE; MICE, INBRED STRAINS; NEOVASCULARIZATION, PHYSIOLOGIC; PLACENTA; PLACENTAL CIRCULATION; PREGNANCY; PREGNANCY, ANIMAL; REGIONAL BLOOD FLOW; REPRODUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84860244390     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.111.095380     Document Type: Article

References (27)

1. Assali NS, Nuwayhid B, Brinkman CR III, Tabsh K, Erkkola R, Ushioda E. Autonomic control of the pelvic circulation: in vivo and in vitro studies in pregnant and nonpregnant sheep. Am J Obstet Gynecol 1981; 141:873-884.
2. Forbes TR, Taku E. Vein size in intact and hysterectomized mice during the estrous cycle and pregnancy. Anat Rec 1975; 182:61-65.
3. Griendling KK, Fuller EO, Cox RH. Pregnancy-induced changes in sheep uterine and carotid arteries. Am J Physiol 1985; 248:H658-H665.
4. Johnson RL, Gilbert M, Meschia G, Battaglia FC. Cardiac output distribution and uteroplacental blood flow in the pregnant rabbit: a comparative study. Am J Obstet Gynecol 1985; 151:682-686.
5. Nienartowicz A, Link S, Moll W. Adaptation of the uterine arcade in rats to pregnancy. J Dev Physiol 1989; 12:101-108.
6. Whitney EA, Ducsay CA, Valenzuela GJ. Is uterine blood flow controlled locally or systemically in the pregnant rabbit? Am J Obstet Gynecol 1993; 169:1507-1509.
7. D'Angelo G, Osol G. Regional variation in resistance artery diameter responses to alpha-adrenergic stimulation during pregnancy. Am J Physiol 1993; 264:H78-H85.
8. Osol G, Cipolla M. Interaction of myogenic and adrenergic mechanisms in isolated, pressurized uterine radial arteries from late-pregnant and nonpregnant rats. Am J Obstet Gynecol 1993; 168:697-705.
9. Osol G, Cipolla M. Pregnancy-induced changes in the three-dimensional mechanical properties of pressurized rat uteroplacental (radial) arteries. Am J Obstet Gynecol 1993; 168:268-274.
10. St-Louis J, Pare H, Sicotte B, Brochu M. Increased reactivity of rat uterine arcuate artery throughout gestation and postpartum. Am J Physiol 1997; 273:H1148-H1153.
11. Osol G, Mandala M. Maternal uterine vascular remodeling during pregnancy. Physiology (Bethesda) 2009; 24:58-71.
12. Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 2002; 8:831-840.
13. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111:649-658.
14. Ni Y, May V, Braas K, Osol G. Pregnancy augments uteroplacental vascular endothelial growth factor gene expression and vasodilator effects. Am J Physiol 1997; 273:H938-H944.
15. Osol G, Celia G, Gokina N, Barron C, Chien E, Mandala M, Luksha L, Kublickiene K. Placental growth factor is a potent vasodilator of rat and human resistance arteries. Am J Physiol Heart Circ Physiol 2008; 294:H1381-H1387.
16. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350:672-683.
17. Wedel Jones C, Mandala M, Barron C, Bernstein I, Osol G. Mechanisms underlying maternal venous adaptation in pregnancy. Reprod Sci 2009; 16:596-604.
18. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 1994; 269:26988-26995.
19. Gille H, Kowalski J, Yu L, Chen H, Pisabarro MT, Davis-Smyth T, Ferrara N. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factordependent phosphatidylinositol 3'-kinase activation and endothelial cell migration. EMBO J 2000; 19:4064-4073.
20. Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci U S A 1998; 95:9349-9354.
21. Mandala M, Gokina N, Barron C, Osol G. Endothelial-derived hyperpolarization factor (EDHF) contributes to PlGF-induced dilation of mesenteric resistance arteries from pregnant rats. J Vasc Res 2011; 49:43-49.
22. Yoo SA, Yoon HJ, Kim HS, Chae CB, De Falco S, Cho CS, Kim WU. Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation. Arthritis Rheum 2009; 60:345-354.
23. Ben Driss A, Benessiano J, Poitevin P, Levy BI, Michel JB. Arterial expansive remodeling induced by high flow rates. Am J Physiol 1997; 272:H851-H858.
24. Langille BL, O'Donnell F. Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science 1986; 231:405-407.
25. Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation 2011; 123:2856-2869.
26. Hirashima M, Lu Y, Byers L, Rossant J. Trophoblast expression of fmslike tyrosine kinase 1 is not required for the establishment of the maternalfetal interface in the mouse placenta. Proc Natl Acad Sci U S A 2003; 100:15637-15642.
27. Fuller R, Barron C, Mandala M, Gokina N, Osol G. Predominance of local over systemic factors in uterine arterial remodeling during pregnancy. Reprod Sci 2009; 16:489-500.