The atlas of dialkylphosphates; assessment of cumulative human organophosphorus pesticides' exposure

Forensic Science International

Volumn 218, Issue 1-3, 2012, Pages 111-122

  Kavvalakis, Matthaios P ^a   Tsatsakis, Aristidis M ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

Biomonitoring; DAP; Dialkylphosphates; Exposure; OP; Organophosphorus; Pesticides

Indexed keywords

ALKANEDIOL DERIVATIVE; ORGANOPHOSPHATE PESTICIDE; PHOSPHORIC ACID DIETHYL ESTER; PHOSPHORIC ACID DIMETHYL ESTER; UNCLASSIFIED DRUG;

AMNION FLUID; ANALYTIC METHOD; ARTICLE; BIOACCUMULATION; BIOLOGICAL MONITORING; BLOOD ANALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; HAIR ANALYSIS; HUMAN; HYDROXYLATION; MECONIUM; MUTAGENESIS; PHOSPHORYLATION; PRIORITY JOURNAL; ROOM TEMPERATURE; URINALYSIS;

EID: 84860236060     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2011.10.019     Document Type: Article

References (77)

1. Tsatsakis A.M., Aguridakis P., Michalodimitrakis M.N., Tsakalov A.K., Alegakis A.K., Koumantakis E., Troulakis G. Experiences with acute organophosphate poisonings in Crete. Veterinary and Human Toxicology 1996, 38:101-107.
2. Tsatsakis A.M., Manousakis A., Anastasaki M., Tzatzarakis M., Katsanoulas K., Delaki C., Agouridakis P. Clinical and toxicological data in fenthion and omethoate acute poisoning. Journal of Environmental Science and Health Part B - Pesticides Food Contaminants and Agricultural Wastes 1998, 33:657-670.
3. Bertsias G.K., Katonis P., Tzanakakis G., Tsatsakis A.M. Review of clinical and toxicological features of acute pesticide poisonings in Crete (Greece) during the period 1991-2001. Medical Science Monitor 2004, 10:CR622-CR627.
4. Wang L.G., Liang Y.C., Jiang X. Analysis of eight organophosphorus pesticide residues in fresh vegetables retailed in agricultural product markets of Nanjing, China. Bulletin of Environmental Contamination and Toxicology 2008, 81:377-382.
5. Dolapsakis G., Vlachonikolis I.G., Varveris C., Tsatsakis A.M. Mammographic findings and occupational exposure to pesticides currently in use on Crete. European Journal of Cancer 2001, 37:1531-1536.
6. Sarabia L., Maurer I., Bustos-Obregon E. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on the mouse testis. Ecotoxicology and Environmental Safety 2009, 72:938-942.
7. Giordano G., Afsharinejad Z., Guizzetti M., Vitalone A., Kavanagh T.J., Costa L.G. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology 2007, 219:181-189.
8. Cakir S., Sarikaya R. Genotoxicity testing of some organophosphate insecticides in the Drosophila wing spot test. Food and Chemical Toxicology 2005, 43:443-450.
9. Kang H.G., Jeong S.H., Cho J.H., Kim D.G., Park J.M., Cho M.H. Chlropyrifos-methyl shows anti-androgenic activity without estrogenic activity in rats. Toxicology 2004, 199:219-230.
10. Yeh S.P., Sung T.G., Chang C.C., Cheng W., Kuo C.M. Effects of an organophosphorus insecticide, trichlorfon, on hematological parameters of the giant freshwater prawn. Macrobrachium rosenbergii (de Man). Aquaculture 2005, 243:383-392.
11. Rodriguez H., Bustos-Obregon E. An in vitro model to evaluate the effect of an organophosphoric agropesticide on cell proliferation in mouse seminiferous tubules. Andrologia 2000, 32:1-5.
12. WHO Environmental health criteria 63: organophosphorus insecticides: a general introduction. IPCS: International Programme on Chemical Safety 1986, WHO (Ed.).
13. Ecobichon D.J., Ozere R.L., Reid E., Crocker J.F.S. Acute fenitrothion poisoning. Canadian Medical Association Journal 1977, 116:377-379.
14. Minton N.A., Murray V.S.G. A review of organo-phosphate poisoning. Medical Toxicology and Adverse Drug Experience 1988, 3:350-375.
15. Tsatsakis A.M., Bertsias G.K., Mammas I.N., Stiakakis I., Georgopoulos D.B. Acute fatal poisoning by methomyl caused by inhalation and transdermal absorption. Bulletin of Environmental Contamination and Toxicology 2001, 66:415-420.
16. Barr D.B., Needham L.L. Analytical methods for biological monitoring of exposure to pesticides: a review. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences 2002, 778:5-29.
17. Barr D.B., Bravo R., Weerasekera G., Caltabiano L.M., Whitehead R.D., Olsson A.O., Caudill S.A., Schober S.E., Pirkle J.L., Sampson E.J., Jackson R.J., Needham L.L. Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the US population. Environmental Health Perspectives 2004, 112:186-200.
18. Hernandez F., Sancho J.V., Pozo O.J. Direct determination of alkyl phosphates in human urine by liquid chromatography/electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2002, 16:1766-1773.
19. Chambers J.E., Carr R.L. Biochemical mechanisms contributing to species differences in insecticidal toxicity. Toxicology 1995, 105:291-304.
20. Margariti M.G., Tsakalof A.K., Tsatsakis A.M. Analytical methods of biological monitoring for exposure to pesticides: Recent update. Therapeutic Drug Monitoring 2007, 29:150-163.
21. Thompson B., Coronado G.D., Vigoren E.M., Griffith W.C., Fenske R.A., Kissel J.C., Shirai J.H., Faustman E.M. Para Ninos Saludables: A community intervention trial to reduce organophosphate pesticide exposure in children of farmworkers. Environmental Health Perspectives 2008, 116:687-694.
22. Wilson N.K., Strauss W.J., Iroz-Elardo N., Chuang J.C. Exposures of preschool children to chlorpyrifos, diazinon, pentachlorophenol, and 2,4-dichlorophenoxyacetic acid over 3 years from 2003 to 2005: a longitudinal model. Journal of Exposure Science and Environmental Epidemiology 2010, 20:546-558.
23. Bradman A., Whitaker D., Quiros L., Castorina R., Henn B.C., Nishioka M., Morgan J., Barr D.B., Harnly M., Brisbin J.A., Sheldon L.S., McKone T.E., Eskenazi B. Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA. Journal of Exposure Science and Environmental Epidemiology 2007, 17:331-349.
24. Rothlein J., Rohlman D., Lasarev M., Phillips J., Muniz J., McCauley L. Organophosphate pesticide exposure and neurobehavioral performance in agricultural and nonagricultural Hispanic workers. Environmental Health Perspectives 2006, 114:691-696.
25. Griffith J.G., Duncan R.C. Alkyl phosphate residue values in the urine of Florida citrus fieldworkers compared to the National-Health-and-Nutrition-Examination-Survey (Hanes) sample. Bulletin of Environmental Contamination and Toxicology 1985, 34:210-215.
26. Aprea C., Sciarra G., Orsi D., Boccalon P., Sartorelli P., Sartorelli E. Urinary excretion of alkylphosphates in the general population (Italy). Science of the Total Environment 1996, 177:37-41.
27. Hardt L., Angerer J. Determination of dialkyl phosphates in human urine using gas chromatography-mass spectrometry. Journal of Analytical Toxicology 2000, 24:678-684.
28. Garcia A.M., Sabater M.C., Mendoza M.T., Ballester F., Carrasco J.M. Exposure to organophosphate pesticides in a general population living in a rice growing area: an exploratory study. Bulletin of Environmental Contamination and Toxicology 2000, 65:764-771.
29. Oglobline A.N., Elimelakh H., Tattam B., Geyer R., O'Donnell G.E., Holder G. Negative ion chemical ionization GC/MS-MS analysis of dialkylphosphate metabolites of organophosphate pesticides in urine of non-occupationally exposed subjects. Analyst 2001, 126:1037-1041.
30. Ueyama J., Saito I., Kamijima M., Nakajima T., Gotoh M., Suzuki T., Shibata E., Kondo T., Takagi K., Miyamoto K., Takamatsu J., Hasegawa T., Takagi K. Simultaneous determination of urinary dialkylphosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences 2006, 832:58-66.
31. Bouvier G., Blanchard O., Momas I., Seta N. Environmental and biological monitoring of exposure to organophosphorus pesticides: application to occupationally and non-occupationally exposed adult populations. Journal of Exposure Science and Environmental Epidemiology 2006, 16:417-426.
32. Cocker J., Mason H.J., Garfitt S.J., Jones K. Biological monitoring of exposure to organophosphate pesticides. Toxicology Letters 2002, 134:97-103.
33. Fenske R.A., Leffingwell J.T. Method for the determination of dialkyl phosphate metabolites in urine for studies of human exposure to malathion. Journal of Agricultural and Food Chemistry 1989, 37:995-998.
34. Drevenkar V., Radic Z., Vasilic Z., Reiner E. Dialkylphosphorus metabolites in the urine and activities of esterases in the serum as biochemical indexes for human absorption of organophosphorus pesticides. Archives of Environmental Contamination and Toxicology 1991, 20:417-422.
35. Edwards J.W., Lee S.G., Heath L.M., Pisaniello D.L. Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia. Environmental Research 2007, 103:38-45.
36. Mills P.K., Zahm S.H. Organophosphate pesticide residues in urine of farmworkers and their children in Fresno County, California. American Journal of Industrial Medicine 2001, 40:571-577.
37. Curl C.L., Fenske R.A., Elgethun K. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environmental Health Perspectives 2003, 111:377-382.
38. Arcury T.A., Grzywacz J.G., Davis S.W., Barr D.B., Quandt S.A. Organophosphorus pesticide urinary metabolite levels of children in farmworker households in eastern North Carolina. American Journal of Industrial Medicine 2006, 49:751-760.
39. Shalat S.L., Donnelly K.C., Freeman N.C.G., Calvin J.A., Ramesh S., Jimenez M., Black K., Coutinho C., Needham L.L., Barr D.B., Ramirez Y. Nondietary ingestion of pesticides by children in an agricultural community on the US/Mexico border: preliminary results. Journal of Exposure Analysis and Environmental Epidemiology 2003, 13:42-50.
40. Aprea C., Strambi M., Novelli M.T., Lunghini L., Bozzi N. Biologic monitoring of exposure to organophosphorus pesticides in 195 Italian children. Environmental Health Perspectives 2000, 108:521-525.
41. Bouvier G., Seta N., Vigouroux-Villard A., Blanchard O., Momas I. Insecticide urinary metabolites in nonoccupationally exposed populations. Journal of Toxicology and Environmental Health Part B - Critical Reviews 2005, 8:485-512.
42. Lambert W.E., Lasarev M., Muniz J., Scherer J., Rothlein J., Santana J., McCauley L. Variation in organophosphate pesticide metabolites in urine of children living in agricultural communities. Environmental Health Perspectives 2005, 113:504-508.
43. Lu C.S., Fenske R.A., Simcox N.J., Kalman D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environmental Research 2000, 84:290-302.
44. Loewenherz C., Fenske R.A., Simcox N.J., Bellamy G., Kalman D. Biological monitoring of organophosphorus pesticide exposure among children of agricultural workers in central Washington State. Environmental Health Perspectives 1997, 105:1344-1353.
45. Castorina R., Bradman A., McKone T.E., Barr D.B., Harnly M.E., Eskenazi B. Cumulative organophosphate pesticide exposure and risk assessment among pregnant women living in an agricultural community: a case study from the CHAMACOS cohort. Environmental Health Perspectives 2003, 111:1640-1648.
46. Bradman A., Eskenazi B., Barr D.B., Bravo R., Castorina R., Chevrier J., Kogut K., Harnly M.E., McKone T.E. Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community. Environmental Health Perspectives 2005, 113:1802-1807.
47. Tzatzarakis M., Koutroulakis D., Sifakis S., Theodoropoulou E., Kabalakis M., Koukoura O., Sigelaki A., Toutoudaki M., Tsatsakis A. Concentration of dialkylphosphate metabolites of organophosphate pesticides in pregnant women's urine in the island of Crete. Toxicology Letters 2008, 180:S88.
48. Engel S.M., Berkowitz G.S., Barr D.B., Teitelbaum S.L., Siskind J., Meisel S.J., Wetmur J.G., Wolff M.S. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. American Journal of Epidemiology 2007, 165:1397-1404.
49. Wolff M.S. Prenatal pesticide and PCB exposures and birth outcomes (vol 61, pg 243). Pediatric Research 2007, 62:450.
50. Berman T., Hochner-Celnikier D., Barr D.B., Needham L.L., Amitai Y., Wormser U., Richter E. Pesticide exposure among pregnant women in Jerusalem, Israel: Results of a pilot study. Environment International 2011, 37:198-203.
51. Eriksson P. Developmental neurotoxicity of environmental agents in the neonate. Neurotoxicology 1997, 18:719-726.
52. Bruckner J.V. Differences in sensitivity of children and adults to chemical toxicity: the NAS panel report. Regulatory Toxicology and Pharmacology 2000, 31:280-285.
53. Heudorf U., Angerer J. Metabolites of organophosphorous insecticides in urine specimens from inhabitants of a residential area. Environmental Research 2001, 86:80-87.
54. Lu C.S., Knutson D.E., Fisker-Andersen J., Fenske R.A. Biological monitoring survey of organophosphorus pesticide exposure among preschool children in the Seattle metropolitan area. Environmental Health Perspectives 2001, 109:299-303.
55. Curl C.L., Fenske R.A., Kissel J.C., Shirai J.H., Moate T.F., Griffith W., Coronado G., Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environmental Health Perspectives 2002, 110:A787-A792.
56. Bradman A., Barr D.B., Henn B.G.C., Drumheller T., Curry C., Eskenazi B. Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a validation study. Environmental Health Perspectives 2003, 111:1779-1782.
57. D. Koutroulakis, M. Tzatzarakis, A.K. Alegakis, S. Sifakis, A. Tsatsakis, Exposure to pesticides during pregnancy by the evaluation of their metabolites concentration in amniotic fluid and maternal urine, Toxicology Letters, in preparation.
58. Moriya F., Chan K.M., Noguchi T.T., Wu P.Y.K. Testing for drugs of abuse in meconium of newborn-infants. Journal of Analytical Toxicology 1994, 18:41-45.
59. Whyatt R.M., Barr D.B. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environmental Health Perspectives 2001, 109:417-420.
60. Tsatsakis A.M., Tzatzarakis M.N., Koutroulakis D., Toutoudaki M., Sifakis S. Dialkyl phosphates in meconium as a biomarker of prenatal exposure to organophosphate pesticides: a study on pregnant women of rural areas in Crete, Greece. Xenobiotica 2009, 39:364-373.
61. Tsatsakis A.M., Barbounis M.G., Kavalakis M., Kokkinakis M., Terzi I., Tzatzarakis M.N. Determination of dialkyl phosphates in human hair for the biomonitoring of exposure to organophosphate pesticides. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences 2010, 878:1246-1252.
62. Margariti M.G., Tsatsakis A.M. Analysis of dialkyl phosphate metabolites in hair using gas chromatography-mass spectrometry: a biomarker of chronic exposure to organophosphate pesticides. Biomarkers 2009, 14:137-147.
63. Christakis-Hampsas M., Tutudakis M., Tsatsakis A.M., Assithianakis P., Alegakis A., Katonis P.G., Michalodimitrakis E.N. Acute poisonings and sudden deaths in Crete: a five-year review (1991-1996). Veterinary and Human Toxicology 1998, 40:228-230.
64. Gunnell D., Eddleston M., Phillips M.R., Konradsen F. The global distribution of fatal pesticide self-poisoning: systematic review. BMC Public Health 2007, 7.
65. Thiermann H., Szinicz L., Eyer P., Zilker T., Worek F. Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning. Chemico-Biological Interactions 2005, 157:345-347.
66. Vale J.A. Toxicokinetic and toxicodynamic aspects of organophosphorus (OP) insecticide poisoning. Toxicology Letters 1998, 103:649-652.
67. Tarbah F.A., Mahler H., Temme O., Daldrup T. An analytical method for the rapid screening of organophosphate pesticides in human biological samples and foodstuffs. Forensic Science International 2001, 121:126-133.
68. Worek F., Koller M., Thiermann H., Szinicz L. Diagnostic aspects of organophosphate poisoning. Toxicology 2005, 214:182-189.
69. Drevenkar V., Vasilic Z., Stengl B., Frobe Z., Rumenjak V. Chlorpyrifos metabolites in serum and urine of poisoned persons. Chemico-Biological Interactions 1993, 87:315-322.
70. Vasilic Z., Drevenkar V., Stengl B., Frobe Z., Rumenjak V. Diethylphosphorus metabolites in serum and urine of persons poisoned by phosalone. Chemico-Biological Interactions 1993, 87:305-313.
71. Bradway D.E., Shafik T.M. Malathion exposure studies - Determination of monocarboxylic-acids and alkyl phosphates in urine. Journal of Agricultural and Food Chemistry 1977, 25:1342-1344.
72. Richter E.D., Kowalski M., Leventhal A., Grauer F., Marzouk J., Brenner S., Shkolnik I., Lerman S., Zahavi H., Bashari A., Peretz A., Kaplanski H., Gruener N., Benishai P. Illness and excretion of organophosphate metabolites 4 months after household pest extermination. Archives of Environmental Health 1992, 47:135-138.
73. Davies J.E., Peterson J.C. Surveillance of occupational, accidental, and incidental exposure to organophosphate pesticides using urine alkyl phosphate and phenolic metabolite measurements. Preventive Strategies for Living in a Chemical World - a Symposium in Honor of Irving J. Selikoff 1997, 257-268. E. Bingham, D.P. Rall (Eds.).
74. A.M. Tsatsakis, M. Tutudaki, M.N. Tzatzarakis, A. Dawson, F. Mohamed, M. Christaki, A. Alegakis, Is hair analysis for dialkyl phosphate metabolites a suitable biomarker for assessing past acute exposure to organophosphate pesticides? Human Experimental Toxicology (2011) March 22 [Epub ahead of print] PMID: 21427137.
75. Hernandez F., Sancho J.V., Pozo O.J. An estimation of the exposure to organophosphorus pesticides through the simultaneous determination of their main metabolites in urine by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences 2004, 808:229-239.
76. Dulaurent S., Saint-Marcoux F., Marquet P., Lachatre G. Simultaneous determination of six dialkylphosphates in urine by liquid chromatography tandem mass spectrometry. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences 2006, 831:223-229.
77. Grandjean P., Harari R., Barr D.B., Debes F. Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children. Pediatrics 2006, 117:E546-E556.