Heart activity and autistic behavior in infants and toddlers with fragile X syndrome

American Journal on Intellectual and Developmental Disabilities

Volumn 117, Issue 2, 2012, Pages 90-102

  Roberts, Jane E ^a   Tonnsen, Bridgette ^a   Robinson, Ashley ^a   Shinkareva, Svetlana V ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Autism spectrum disorder; Fragile X syndrome; Heart activity; Physiological arousal

Indexed keywords

ARTICLE; AUTISM; CHILD BEHAVIOR; CHILD DEVELOPMENT; CROSS-SECTIONAL STUDY; FRAGILE X SYNDROME; HEART; HEART RATE; HOSPITALIZATION; HUMAN; INFANT; INNERVATION; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; VAGUS NERVE;

AUTISTIC DISORDER; CHILD DEVELOPMENT; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FRAGILE X SYNDROME; HEART; HEART RATE; HUMANS; INFANT; INFANT BEHAVIOR; MALE; SEVERITY OF ILLNESS INDEX; VAGUS NERVE;

EID: 84860234558     PISSN: 19447515     EISSN: 19447558     Source Type: Journal    
DOI: 10.1352/1944-7558-117.2.90     Document Type: Article

References (51)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2. Bailey, D. B., Jr., Hatton, D. D., Skinner, M., & Mesibov, G. (2001). Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. Journal of Autism and Developmental Disorders, 31, 165-174. (Pubitemid 37490162)
3. Bailey, D. B., Jr., Raspa, M., Holiday, D., Bishop, E., & Olmsted, M. (2009). Functional skills of individuals with fragile X syndrome: A lifespan cross-sectional analysis. American Journal on Intellectual and Developmental Disabilities, 114, 289-303.
4. Bal, E., Harden, E., Lamb, D., Van Hecke, A. V., Denver, J. W., & Porges, S. W. (2010). Emotion recognition in children with autism spectrum disorders: Relations to eye gaze and autonomic state. Journal of Autism and Developmental Disorders, 40, 358-370.
5. Baranek, G. T., Danko, C. D., Skinner, M. L., Bailey, D. R., Hatton, D. D., Roberts, J. E., & Mirrett, P. L. (2005). Video analysis of sensorymotor features in infants with fragile X syndrome at 9-12 months of age. Journal of Autism and Developmental Disorders, 35, 645-656.
6. Baranek, G. T., Wakeford, L., & David, F. J. (2008). Understanding, assessing, and treating sensory-motor issues. In K. Chawarska, A. Klin, & F. R. Volkmar, (Eds.), Autism spectrum disorders in infants and toddlers: Diagnosis, assessment, and treatment (pp. 104-140). New York: Guilford Press.
7. Chiu, S., Wegelin, J. A., Blank, J., Jenkins, M., Day, J., Hessl, D.,⋯Hagerman, R. (2007). Early acceleration of head circumference in children with fragile X syndrome and autism. Journal of Developmental and Behavioral Pediatrics, 28, 31-35. (Pubitemid 46423269)
8. Crawford, D. C., Meadows, K. L., Newman, J. L., Taft, L. F., Scott, E., Leslie, M.,⋯Sherman, S. L. (2002). Prevalence of the fragile X syndrome in African-Americans. American Journal of Medical Genetics, 110, 226-233. (Pubitemid 34627626)
9. Fox, N. A. (1989). Psychophysiological correlates of emotional reactivity during the first year of life. Developmental Psychology, 25, 364-372.
10. Goldsmith, H., Lemery-Chalfant, K., Schmidt, N. L., Arneson, C. L., & Schmidt, C. K. (2007). Longitudinal analyses of affect, temperament, and childhood psychopathology. Twin Research and Human Genetics, 10, 118-126. (Pubitemid 46423382)
11. Goldsmith, H. H., & Rothbart, M. K. (1994). Manual for the Laboratory Temperament Assessment Battery (Version 2.03). Unpublished manuscript.
12. Hagerman, R. J. (2002). The physical and behavioral phenotype. In R. J. Hagerman & P. J. Hagerman (Eds.), Fragile X syndrome: Diagnosis, treatment, and research (3rd ed., pp. 3-109). Baltimore: Johns Hopkins University Press.
13. Hagerman, R. J., Berry-Kravis, E., Kaufmann, W. E., Ono, M. Y., Tartaglia, N., Lachiewicz, A.,⋯Tranfaglia, M. (2009). Advances in the treatment of fragile X syndrome. Pediatrics, 123, 378-390.
14. Hagerman, R. J., Hall, D. A., Coffey, S., Leehey, M., Bourgeois, J., Gould, J.,⋯Hagerman, P. J. (2008). Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems. Journal of Clinical Interventions in Aging, 3, 251-262. (Pubitemid 352037865)
15. Hall, S. S., Lightbody, A. A., Huffman, L. C., Lazzeroni, L. C., & Reiss, A. L. (2009). Physiological correlates of social avoidance behavior in children and adolescents with fragile X syndrome. Journal of the American Academy of Child & Adolescent Psychiatry, 48, 320-329.
16. Hall, S. S., Lightbody, A. A., & Reiss, A. L. (2008). Compulsive, self-injurious, and autistic behavior in children and adolescents with fragile X syndrome. American Journal on Mental Retardation, 113, 44-53.
17. Hatton, D. D., Hooper, S. R., Bailey, D. B., Skinner, M. L., Sullivan, K. M., & Wheeler, A. (2002). Problem behavior in boys with fragile X syndrome. American Journal of Medical Genetics, 108, 105-116.
18. Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D. B., Jr., Roberts, J., & Mirrett, P. (2006). Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics, 140A, 1804-1813. (Pubitemid 44330644)
19. Hayes, A. F., & Matthes, J. (2009). Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations. Behavior Research Methods, 41, 924-936.
20. Hazlett, H. C., Poe, M. D., Lightbody, A. A., Gerig, G., Macfall, J. R., Ross, A. K.,⋯Piven, J. (2009). Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism. Journal of Neurodevelopmental Disorders, 1, 81-90.
21. Hessl, D., Glaser, B., Dyer-Friedman, J., & Reiss, A. L. (2006). Social behavior and cortisol reactivity in children with fragile X syndrome. Journal of Child Psychology and Psychiatry, 47, 602-610. (Pubitemid 43744791)
22. Hoeft, F., Carter, J. C., Lightbody, A. A., Hazlett, H., Piven, J., & Reissa, A. L. (2010). Regionspecific alterations in brain development in one- to three-year-old boys with fragile X syndrome. Proceedings of the National Academy of Sciences of the United States of America, 107, 9335-9339.
23. Hoeft, F., Lightbody, A. A., Hazlett, H. C., Patnaik, S., Piven, J., & Reiss, A. L. (2008). Morphometric spatial patterns differentiating boys with fragile X syndrome, typically developing boys, and developmentally delayed boys aged 1 to 3 years. Archives of General Psychiatry, 65, 1087-1097.
24. Huffman, L. C., Bryan, Y. E., del Carmen, R., Pedersen, F. A., Doussard-Roosevelt, J. A., & Porges, S. W. (1998). Infant temperament and cardiac vagal tone: Assessments at twelve weeks of age. Child Development, 69, 624-635. (Pubitemid 128656056)
25. Johnson, P. O., & Fay, L. C. (1950). The Johnson- Neyman technique, its theory and application. Psychometrika, 15, 349-367.
26. Kaufmann, W. E., Cortell, R., Kau, A. S., Bukelis, I., Tierney, E., Gray, R. M.⋯Stanard, P. (2004). Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors. American Journal of Medical Genetics, 129A, 225-234. (Pubitemid 39166187)
27. Kochanska, G., Murray, K., Jacques, T. Y., & Koenig, A. L. (1996). Inhibitory control in young children and its role in emerging internalization. Child Development, 67, 490-507. (Pubitemid 126420286)
28. Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M., & McLennan, J. (1989). Autism diagnostic interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 363-387. (Pubitemid 19233509)
29. Lewis, M., Alessandri, S. M., & Sullivan, M. W. (1990). Violation of expectancy, loss of control, and anger expressions in young infants. Developmental Psychology, 26, 745-751.
30. Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C.,⋯Rutter, M. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205-223.
31. Ming, X., Julu, P. O., Brimacombe, M., Connor, S., & Daniels, M. L. (2005). Reduced cardiac parasympathetic activity in children with autism. Brain Development, 27, 509-516. (Pubitemid 41383492)
32. Mullen, E. M. (1995). The Mullen Scales of Early Learning. Circle Pines, MN: American Guidance Service.
33. Porges, S. W., Doussard-Roosevelt, J. A., Portales, A. L., & Greenspan, S. I. (1996). Infant regulation of the vagal ''brake'' predicts child behavior problems: A psychobiological model of social behavior. Developmental Psychobiology, 29, 697-712. (Pubitemid 126478407)
34. Porter, C. L., Jones, B. L., Evans, C. A., & Robinson, C. C. (2009). A comparative study of arm-restraint methodology: Differential effects of mother and stranger restrainers on infants' distress reactivity at 6 and 9 months of age. Infancy, 14, 306-324.
35. Roberts, J. E., Boccia, M. L., Bailey, D. B., Jr., Hatton, D. D., & Skinner, M. (2001). Cardiovascular indices of physiological arousal in boys with fragile X syndrome. Developmental Psychobiology, 39, 107-123.
36. Roberts, J. E., Boccia, M. L., Hatton, D. D., Skinner, M. L., & Sideris, J. (2006). Temperament and vagal tone in boys with fragile X syndrome. Journal of Developmental and Behavioral Pediatrics, 27, 193-201. (Pubitemid 44318246)
37. Roberts, J. E., Clarke, M. A., Alcorn, K., Carter, J. C., Long, A. J., & Kaufmann, W. E. (2009a). Autistic behavior in boys with fragile X syndrome: Social approach and HPA-axis dysfunction. Journal of Neurodevelopmental Disorders, 1, 283-291.
38. Roberts, J. E., Hatton, D. D., Long, A. C., Anello, V., & Colombo, J. (2011, July 1). Visual attention and autistic behavior in infants with fragile X syndrome. Journal of Autism and Developmental Disorders. doi: 10.1007/s10803- 011-1316-8
39. Roberts, J. E., Mankowski, J. B., Sideris, J., Goldman, B. D., Hatton, D. D., Mirrett, P. L.,⋯Bailey, D. B. (2009b). Trajectories and predictors of the development of very young boys with fragile X syndrome. Journal of Pediatric Psychology, 34, 827-836.
40. Roberts, J. E., McDonald, L. M., Kelleher, B. L., & Hatton, D. D. (2010, July). Social responsivity in infants with fragile X syndrome over time. Paper presented at the 12th Annual Meeting of the National Fragile X Foundation, Detroit.
41. Rogers, S. J., Wehner, D. E., & Hagerman, R. (2001). The behavioral phenotype in fragile X: Symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders. Journal of Developmental and Behavioral Pediatrics, 22, 409-417. (Pubitemid 34026944)
42. Rothbart, M. K., Ahadi, S. A., & Evans, D. E. (2000). Temperament and personality: Origins and outcomes. Journal of Personality and Social Psychology, 78, 122-135.
43. Sarimski, K. (2010). Perceived quality of life in mothers of young boys with fragile X syndrome. Prax Kinderpsychol Kinderpsychiatr, 59, 389-403.
44. Schopler, E., Reichler, R. J., & Renner, B. R. (1988). The Childhood Autism Rating Scale (CARS). Los Angeles: Western Psychological Services.
45. Shanahan, M. M., Roberts, J. J., Hatton, D. D., Reznick, J. J., & Goldsmith, H. H. (2008). Early temperament and negative reactivity in boys with fragile X syndrome. Journal of Intellectual Disability Research, 52, 842-854.
46. Sherman, M., & Sherman, I.C. (1925). Sensorimotor responses in infants. Journal of Comparative Psychology, 5, 53-68.
47. Short, A. B., & Schopler, E. (1988). Factors relating to age of onset in autism. Journal of Autism and Developmental Disorders, 18, 207-216.
48. Stifter, C. A., & Jain, A. (1996). Psychophysiological correlates of infant temperament: Stabil-ity of behavior and autonomic patterning from 5 to 18 months. Developmental Psychobiology, 29, 379-391. (Pubitemid 126467344)
49. Van Hecke, A., Lebow, J., Bal, E., Lamb, D., Harden, E., Kramer, A.,⋯Porges, S. W. (2009). Electroencephalogram and heart rate regulation to familiar and unfamiliar people in children with autism spectrum disorders. Child Development, 80, 1118-1133.
50. Yoder, P., Stone, W. L., Walden, T., & Malesa, E. (2009). Predicting social impairment and ASD diagnosis in younger siblings of children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 1381-1391.
51. Zwaigenbaum, L., Bryson, S., Roberts, W., Rogers, T., Brian, J., & Szatmari P. (2005). Behavioral markers of autism in the first year of life. International Journal of Developmental Neurosciences, 23, 143-152. (Pubitemid 40313548)