Trajectories and predictors of the development of very young boys with fragile X syndrome

Journal of Pediatric Psychology

Volumn 34, Issue 8, 2009, Pages 827-836

  Roberts, Jane E ^a,e   Mankowski, Jean B ^a   Sideris, John ^a   Goldman, Barbara Davis ^a,b   Hatton, Deborah D ^a   Mirrett, Penny L ^a   Baranek, Grace T ^c   Reznick, J Steven ^b   Long, Anna C J ^a   Bailey, Donald B ^d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d RTI INTERNATIONAL   (United States)

^e UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cognitive development; Fmr1; Fragile X

Indexed keywords

ARTICLE; AUTISM; BEHAVIOR; CHILD; CHILD DEVELOPMENT; CHRONOLOGY; COGNITIVE DEVELOPMENT; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FRAGILE X SYNDROME; GENE MUTATION; HUMAN; INFANT; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MENTAL DEFICIENCY; MOTHER; PREDICTOR VARIABLE; PRESCHOOL CHILD; PSYCHOLOGIST; VISION;

AGE FACTORS; AUTISTIC DISORDER; CHILD, PRESCHOOL; COMORBIDITY; DEVELOPMENTAL DISABILITIES; DIAGNOSIS, DIFFERENTIAL; EARLY INTERVENTION (EDUCATION); FRAGILE X SYNDROME; HUMANS; INFANT; INTELLIGENCE; LONGITUDINAL STUDIES; MALE;

EID: 69249202393     PISSN: 01468693     EISSN: 1465735X     Source Type: Journal    
DOI: 10.1093/jpepsy/jsn129     Document Type: Article

References (35)

1. American Academy of Pediatrics, Council on Children With Disabilities; Section on Developmental Behavioral Pediatrics; Bright Futures Steering Committee; Medical Home Initiatives for Children with Special Needs Project Advisory Committee. (2006). Identifying infants and young children with developmental disorders in the medical home: An algorithm for developmental surveillance an screening. Pediatrics, 107, 1084-1094.
2. Bailey, D. B. Jr, Hatton, D. D., & Skinner, M. (1998). Early developmental trajectories of males with fragile X syndrome. American Journal of Mental Retardation, 103, 29-39.
3. Bailey, D. B. Jr, Hatton, D. D., Skinner, M., & Mesibov, G. (2001). Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. Journal of Autism and Developmental Disorders, 31, 165-174.
4. Bailey, D. B., Raspa, M., Olmsted, M., & Holiday, D. (2008). Co-occurring conditions associated with FMR1 gene variations: Findings from a national parent survey. American Journal of Medical Genetics Part A, 146A, 2060-2069.
5. Bailey, D. B., Sideris, J., Roberts, J., & Hatton, D. (2008). Child and genetic variables associated with maternal adaptation to fragile X syndrome: A multidimensional analysis. American Journal of Medical Genetics, Part A, 146A, 720-729.
6. Bailey, D. B. Jr, Skinner, D., & Sparkman, K. L. (2003). Discovering fragile X syndrome: family experiences and perceptions. Pediatrics, 111, 407-416.
7. Baranek, G. T., Danko, C. D., Skinner, M. L., Bailey, D. B. Jr., Hatton, D. D., Roberts, J. E., et al. (2005). Video analysis of sensory-motor features in infants with fragile X syndrome at 9-12 months of age. Journal of Autism and Developmental Disorders, 35, 645-656.
8. Baranek, G. T., Roberts, J. E., David, F. L., Sideris, J., Mirrett, P. L., Hatton, D. D., et al. (2008). Developmental trajectories and correlates of sensory processing in young boys with fragile X syndrome. Physical & Occupational Therapy in Pediatrics, 28, 79-98.
9. Benjamini, Y., & Hochberg (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of Royal Statistical Society, 57, 289-300.
10. Council on Children with Disabilities, Section on Developmental Behavioral Pediatrics, Bright Futures Steering Committee, Medical Home Initiatives for Children with Special Needs Project Advisory Committee (2006). Identifying infants and young children with developmental disorders in the medical home: An algorithm for developmental surveillance and screening. Pediatrics, 118, 405-420.
11. Crawford, D. C., Acuna, J. M., & Sherman, S.L. (2001). FMR1 and the fragile X syndrome: human genome epidemiology review. Genetics in Medicine, 3, 359-371.
12. Dyer-Friedman, J., Glaser, B., Hessl, D., Johnston, C., Huffman, L. C., Taylor, A., et al. (2002). Genetic and environmental influences on the cognitive outcomes of children with fragile X syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 41 , 237-244.
13. Freund, L. S., Peebles, C. D., Aylward, E., & Reiss, A. L. (1995). Preliminary report on cognitive and adaptive behavior of preschool-aged males with fragile X. Developmental Brain Dysfunction, 8, 242-251.
14. Glascoe, F. P. (2000). Detecting and addressing developmental and behavioral problems in primary care. Pediatric Nursing, 26, 251-257.
15. Hagerman, R. J., Hull, C. E., Safanda, J. F., Carpenter, I., Staley, L. W., O'Connor, R. A., et al. (1994). High functioning fragile X males: Demonstration of an unmethylated fully expanded FMR-1 mutation associated with protein expression. American Journal of Medical Genetics, 51, 298-308.
16. Hatton, D.D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D.B. Jr, Roberts, J., et al. (2006). Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics Part A, 140, 1804-1813.
17. Humphrey, A., Williams, J., Pinto, E., & Bolton, P.F. (2004). A prospective longitudinal study of early cognitive development in tuberous sclerosis: A clinic based study. European Child and Adolescent Psychiatry, 13 , 159-165.
18. IDEA: Individuals with Disabilities Education Act (2004). U.S. Department of Education, Office of Special Education Program 632[5][A].
19. Kaufmann, W. E., Cortell, R., Kau, A. S., Bukelis, I., Tierney, E., Gray, R. M., et al. (2004). Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors. American Journal of Medical Genetics A, 129, 225-234.
20. Minquez, M., Ibainez, B., Ribate, M. P., Ramos, F., Garcia-Alegria, E., Fernandez-Rivas, A., et al. (2008). Risk of cognitive impairment in female premutation carriers of fragile X premutation: Analysis by means of robust segmented linear regression models. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
21. Mirrett, P. L., Bailey, D. B. Jr, Roberts, J. E., & Hatton, D. D. (2004). Developmental screening and detection of developmental delays in infants and toddlers with fragile X syndrome. Journal of Development and Behavioral Pediatrics, 25, 21-27.
22. Mullen E.M. (1995). Mullen Scales of Early Learning: AGS Edition Manual. Circle Pines, MN: AGS.
23. Roberts, J. E., Bailey, D. B. Jr, Mankowski, J., Ford, A., Sideris, J., Weisenfeld, L. A., et al. (2008). Mood and anxiety disorders in females with the FMR1 premuta-tion. American Journal of Medical Genetics [Epub ahead of print].
24. Roberts, J. E., Hatton, D. D., & Bailey, D. B. (2001). Development and behavior of male toddlers with fragile X syndrome. Journal of Early Intervention, 24, 207-223.
25. Roberts, J. E, Schaaf, J. M., Skinner, M., Wheeler, A., Hooper, S., Hatton, D. D., et al. (2005). Academic skills of boys with fragile X syndrome: Profiles and predictors. American Journal on Mental Retardation, 110, 107-120.
26. Rogers, S. J., Wehner, D. E., & Hagerman, R. (2001). The behavioral phenotype in fragile X: symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders. Journal of Development and Behavioral Pediatrics, 22, 409-417.
27. Sand, N., Silverstein, M., Glascoe, F. P., Gupta, V. B., Tonniqes, T. P., & O'Connor, K. G. (2005). Pediatricians' reported practices regarding developmental screening: do guidelines work? Do they help? Pediatrics, 116, 174-179.
28. SAS Institute (2003). SAS System, Version 9. Cary, NC: SAS Institute.
29. Schopler, E., Reichler, R., & Renner, B (1988). The childhood autism rating scale (CARS). Los Angeles, CA: Western Psychological Servies.
30. Shanahan, M. E., Roberts, J. E., Hatton, D. D., Reznick, J. S., & Goldsmith, H. H. (2008). Early temperament and negative reactivity in boys with fragile X syndrome. Journal of Intellectual Disability Research, 52, 842-854.
31. Skinner, M., Hooper, S., Hatton, D. D., Roberts, J., Mirret, P., Schaaf, J., Sullivan, K., Wheeler, A., Bailey, & D. B. Jr. (2005). Mapping nonverbal IQ in young boys with fragile X syndrome. American Journal of Medical Genetics, 132, 25-32. (Pubitemid 40070556)
32. Srour, M., Mazer, B., & Shevell, M.I. (2006). Analysis of clinical features predicting etiologic yield in the assessment of global developmental delay. Pediatrics, 118, 139-145.
33. Sterling, A., Brady, N., Warren, S., Fleming, K., & Marquis, J. (2006, March). What factors influence maternal responsivity in mothers of young children with fragile X syndrome? Poster session presented at the annual meeting of the Gatlinburg Conference on Research and Theory in Mental Retardation and Developmental Disabilities. San Diego: CA.
34. Visootsak, J., Warren, S. T., Anido, A., Graham, & J. M. Jr. (2005). Fragile X syndrome: An update and review for the primary pediatrician. Clinical Pediatrics, 44, 371-381.
35. Wechsler, D. (1999). Wechsler Abbreviated Scale of Intelligence. San Antonio, TX: Psychological Corporation.