Changes in immunologic parameters of humoral immunity and adipocytokines in obese persons are gender dependent

Human Immunology

Volumn 73, Issue 5, 2012, Pages 486-492

  Szabová, Michaela ^a   Jahnová, Eva ^a   Horváthová, Mira ^a   Ilavská, Silvia ^a   Pružincová, Veronika ^a   Nemessányi, Tomáš ^a   Tulinská, Jana ^a   Wsólová, Ladislava ^a   Volkovová, Katarína ^a  

^a SLOVAK MEDICAL UNIVERSITY   (Slovakia)

Author keywords

Adiponectin; CRP; Inflammation; Leptin; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 6; LEPTIN; SELECTIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; FEMALE; HUMAN; HUMORAL IMMUNITY; MAJOR CLINICAL STUDY; MALE; MORBID OBESITY; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEX DIFFERENCE;

ADIPONECTIN; ADULT; BODY MASS INDEX; C-REACTIVE PROTEIN; COMPLEMENT C3; COMPLEMENT C4; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNITY, HUMORAL; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; LECTINS; MALE; MIDDLE AGED; NEPHELOMETRY AND TURBIDIMETRY; OBESITY; SELECTINS; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 84860231514     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2012.02.006     Document Type: Article

References (33)

1. Van Dielen F.M.H., Van't Veer C., Schols A.M., Soeters P.B., Buurman W.A., Greve J.W.M. Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord 2001, 25:1759-1766.
2. Rasouli N., Kern P.A. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008, 93:S64-S73.
3. Gil-Campos M., Cañete R.R., Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr 2004, 23:963-974.
4. Iikuni N., Lam Q.L.K., Lu L., Matarese G., La Cava A. Leptin and Inflammation. Curr. Immunol Rev 2008, 4:70-79.
5. Bidad K., Moayeri H., Nicknam M.H. Leptin and immunology of obesity. Iran J Diabetes Lipid Disord 2010, 9:8-14.
6. Lang K., Ratke J. Leptin and adiponectin: new players in the field of tumor cell and leukocyte migration. Cell Commun Signal 2009, 23:7-27.
7. Shamsuzzaman A.S.M., Winnicki M., Wolk R., Svatikova A., Phillips B.G., Davison D.E., et al. Independent association between plasma Leptin and C-reactive protein in healthy humans. Circulation 2004, 109:2181-2185.
8. Matsubara M., Maruoka S., Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal weight and obese women. Eur J Endocrinol 2002, 147:173-180.
9. O'Rourke R.W. Inflammation in obesity-related disease. Surgery 2009, 145:255-259.
10. Fried S.K., Bunkin D.A., Greenberg A.S. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998, 83:847-850. Greenberg AS.
11. Malavazos A.E., Corsi M.M., Ermetici F., Coman C., Sardanelli F., Rossi A., et al. Proinflammatory cytokines and cardiac abnormalities in uncomplicated obesity: Relationship with abdominant fat deposition. Nutr Metab Cardiovasc Dis 2007, 17:294-302.
12. Eder K., Baffy N., Falus A., Fulop A.K. The major inflammatory mediator interleukin-6 and obesity. Inflamm Res 2009, 58:727-736.
13. Straub R.H., Hense H.W., Andus T., Schilmerich J., Riegger G.A.J., Schunkert H. Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: A population-based study. J Clin Endocrinol Metab 2000, 85:1340-1344.
14. Park H.S., Park J.Y., Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Res Clin Pract 2005, 69:29-35.
15. Gilardini L., McTernan P.G., Girola A., da Silva N.F., Alberti L., Kumar S., Invitti C. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis 2006, 189:401-407.
16. Muscari A., Antonelli S., Bianchi G., Cavrini G., Dapporto S., Ligabue A., et al. Serum C3 Is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate. Diabetes Care 2007, 30:2362-2368.
17. Onat A., Hergenç G., Can G., Kaya Z., Y°ksel H. Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in midlle-aged population. Metabolism 2010, 59:628-634.
18. Engstrõm G., Hedblad B., Eriksson K.F., Janzon L., Lindgärge F. Complement C3 Is a risk factor for the development of diabetes. Diabetes 2005, 54:570-575.
19. Ferri C., Desideri G., Valenti M., Bellini C., Pasin M., Santucci A., et al. Early upregulation of endothelial adhesion molecules in obese hypertensive men. Hypertension 1999, 34:568-573.
20. Matsumoto K., Sera Y., Abe Y., Tominaga T., Horikami K., Hirao K., et al. High serum concentrations of soluble E-selectin correlate with obesity but not fat distribution in patients with type 2 diabetes mellitus. Metabolism 2002, 51:932-934.
21. Glowinska B., Urban M., Peczynska J., Florys B. Soluble adhesion molecules (sICAM-1, sVACM-1) and selectins äsE-selectin, sP-selectin, sL-selectin) levels in children and adolescents with obesity, hypertension, and diabetes. Metabolism 2005, 54:1020-1026.
22. Gabrielsson B.G., Johansson J.M., Lõnn M., Jernås M., Olbers T., Peltonen M., et al. High expression of complement components in omental adipose tissue in obese men. Obes Res 2003, 11:699-708.
23. Ford E.S. Body mass index, diabetes, and C-reactive protein among U.S. adults. Diabetes Care 1999, 22:1971-1977.
24. Hersoug L.G., Linneberg A. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance?. Allergy 2007, 62:1205-1213.
25. Bastard J.P., Maachi M., Lagathu C., Kim M.J., Caron M., Vidal H., et al. Recent advances in the relationship between obesity, inflammation, and insuline resistance. Eurcytokine Netw 2006, 17:4-12.
26. Rexrode K.M., Pradhan A., Manson J.E., Buring J.E., Ridker P.M. Relationship of total and abdominal adiposity with CRP and IL-6 in women. Ann Epidemiol 2003, 13:674-682.
27. Nash M.C., Wade A.M., Shah V., Dillon M.J. Normal levels of soluble E-selectin, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 decrease with age. Clin Exp Immunol 1996, 103:167-170.
28. Zdrojowy K., Knapik-Kordecka M., Jakobsche-Policht U., Adamiec R. Evaluation of proinflammaotry cytokines in chronic lower limb ischeemia diabetic macroangiopathy and arteriosclerosis obliterans. Pol Merkur Lek 2009, 27:458-462.
29. Leptin S.A., Stofkova A. Adiponectin: from energy and Metabolic Dysbalance to inflammation and autoimmunity. Endocr Regul 2009, 43:157-168.
30. Hotta K., Funahashi T., Arita Y., Takahashi M., Matsuda M., Okamoto Y., et al. Plasma concentrations of novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000, 20:1595-1599.
31. Manigrasso M.R., Ferroni P., Santilli F., Taraborelli T., Guagnano M.T., Michetti N., et al. Association between circulating adiponectin and interleukin-10 levels in android obesity: effects of weight loss. JCEM 2005, 90:5876-5879.
32. Otero M., Lago R., Gomez R., Dieguez C., Lago F., Gómez-Reino J., et al. Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology 2006, 45:944-950.
33. Chow V.T.K., Phoon M.C. Measurement of serum Leptin concentrations in university undergraduates by competitive ELISA reveals correlations with body mass index and sex. Adv Physiol Educ 2003, 27:70-77.