Inducible cardiac ischaemia is related to a decrease in the whole-blood Toll-like receptor 2 and 4 response

Clinical Science

Volumn 122, Issue 11, 2012, Pages 527-533

  Elsenberg, Ellen H A M ^a   Versteeg, Dik ^a   Sels, Jan Willem ^b   Vlaar, Pieter Jan J ^c   Hobbelink, Monique G G ^a   Cramer, Maarten Jan M ^a   De Kleijn, Dominique P V ^a,d   Tio, René A ^c   De Smet, Bart J G L ^c   Doevendans, Pieter A ^a,d   Hoefer, Imo E ^a   Pasterkamp, Gerard ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b CATHARINA HOSPITAL   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Atherosclerosis; Ischaemia; Leucocyte; Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI); Toll like receptor

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CD11B ANTIGEN; CLOPIDOGREL; COUMARIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 8; NITRATE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CYTOKINE PRODUCTION; FEMALE; GRANULOCYTE; HEART MUSCLE ISCHEMIA; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MYOCARDIAL PERFUSION IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; BLOOD; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHYSIOLOGY; STRESS ECHOCARDIOGRAPHY;

ADULT; ECHOCARDIOGRAPHY, STRESS; FEMALE; HUMANS; INTERLEUKIN-8; LEUKOCYTE COUNT; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84860230338     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20110323     Document Type: Article

References (24)

1. Akira, S. and Takeda, K. (2004) Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511.
2. Medzhitov, R., Preston-Hurlburt, P. and Janeway, Jr, C. A. (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397.
3. Sabroe, I., Jones, E. C., Usher, L. R., Whyte, M. K. and Dower, S. K. (2002) Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J. Immunol. 168, 4701-4710.
4. Edfeldt, K., Swedenborg, J., Hansson, G. K. and Yan, Z. Q. (2002) Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation 105, 1158-1161.
5. Vink, A., Schoneveld, A. H., van der Meer, J. J., Van Middelaar, B. J., Sluijter, J. P., Smeets, M. B., Quax, P. H., Lim, S. K., Borst, C., Pasterkamp, G. and de Kleijn, D. P. (2002) In vivo evidence for a role of Toll-like receptor 4 in the development of intimal lesions. Circulation 106, 1985-1990.
6. Arslan, F., Keogh, B., McGuirk, P. and Parker, A. E. (2010) TLR2 and TLR4 in ischemia reperfusion injury. Mediators Inflamm. 2010, 704202.
7. Ionita, M. G., Arslan, F., de Kleijn, D. P. and Pasterkamp, G. (2010) Endogenous inflammatory molecules engage Toll-like receptors in cardiovascular disease. J. Innate Immun. 2, 307-315.
8. Cole, J. E., Georgiou, E. and Monaco, C. (2010) The expression and functions of toll-like receptors in atherosclerosis. Mediators Inflamm. 2010, 393946.
9. Versteeg, D., Hoefer, I. E., Schoneveld, A. H., de Kleijn, D. P., Busser, E., Strijder, C., Emons, M., Stella, P. R., Doevendans, P. A. and Pasterkamp, G. (2008) Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention: association with lesion stenosis and fractional flow reserve. Heart 94, 770-776.
10. Versteeg, D., Dol, E., Hoefer, I. E., Flier, S., Buhre, W. F., de Kleijn, D., van Dongen, E. P., Pasterkamp, G. and de Vries, J. P. (2009) Toll-like receptor 2 and 4 response and expression on monocytes decrease rapidly in patients undergoing arterial surgery and are related to preoperative smoking. Shock 31, 21-27.
11. Strauss, H. W., Harrison, K., Langan, J. K., Lebowitz, E. and Pitt, B. (1975) Thallium-201 for myocardial imaging. Relation of thallium-201 to regional myocardial perfusion. Circulation 51, 641-645.
12. Harter, L., Mica, L., Stocker, R., Trentz, O. and Keel, M. (2004) Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis. Shock 22, 403-409.
13. Brunialti, M. K., Martins, P. S., Barbosa de, C. H., Machado, F. R., Barbosa, L. M. and Salomao, R. (2006) TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock. Shock 25, 351-357.
14. Mendes, M. E., Baggio-Zappia, G. L., Brunialti, M. K., Fernandes, M. D., Rapozo, M. M. and Salomao, R. (2011) Differential expression of toll-like receptor signaling cascades in LPS-tolerant human peripheral blood mononuclear cells. Immunobiology 216, 285-295.
15. Medvedev, A. E., Sabroe, I., Hasday, J. D. and Vogel, S. N. (2006) Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J. Endotoxin Res. 12, 133-150.
16. Kariko, K., Weissman, D. and Welsh, F. A. (2004) Inhibition of toll-like receptor and cytokine signaling - a unifying theme in ischemic tolerance. J. Cereb. Blood Flow Metab. 24, 1288-1304.
17. Draisma, A., Pickkers, P., Bouw, M. P. and van der Hoeven, J. G. (2009) Development of endotoxin tolerance in humans in vivo. Crit. Care Med. 37, 1261-1267.
18. +) monocytes: a role in the anti-inflammatory influence of exercise? J. Leukocyte Biol. 84, 1271-1278.
19. Simpson, R. J., McFarlin, B. K., McSporran, C., Spielmann, G., Hartaigh, B. and Guy, K. (2009) Toll-like receptor expression on classic and pro-inflammatory blood monocytes after acute exercise in humans. Brain Behav. Immun. 23, 232-239.
20. Tanaka, Y., Kawanishi, N., Shiva, D., Tsutsumi, N., Uchida, M., Kitamura, H., Kato, Y. and Yano, H. (2010) Exhaustive exercise reduces tumor necrosis factor-α production in response to lipopolysaccharide in mice. Neuroimmunomodulation 17, 279-286.
21. Gleeson, M., McFarlin, B. and Flynn, M. (2006) Exercise and Toll-like receptors. Exercise Immunol. Rev. 12, 34-53.
22. Oliveira, M. and Gleeson, M. (2010) The influence of prolonged cycling on monocyte Toll-like receptor 2 and 4 expression in healthy men. Eur. J. Appl. Physiol. 109, 251-257.
23. de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., vanWesterloo, D. J., Bennink, R. J., Berthoud, H. R., Uematsu, S., Akira, S., van den Wijngaard, R. M. and Boeckxstaens, G. E. (2005) Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat. Immunol. 6, 844-851.
24. Tracey, K. J. (2002) The inflammatory reflex. Nature 420, 853-859